Patents by Inventor Aykut Üren

Aykut Üren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CD99 inhibitors and their uses
    Patent number: 11202792
    Abstract: Provided herein are methods of treating a bone or connective tissue cancer in a subject. The methods comprise administering to the subject an effective amount of a CD99 inhibitor, wherein the CD99 inhibitor is a compound having the formula wherein R, each of which may be the same or different, is hydrogen, or a protecting group; wherein Z is selected from the group consisting of F, Cl and Br; wherein X is H or F; and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: December 21, 2021
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Aykut Üren, Haydar Celik, Jeffrey A. Toretsky
  • CD99 Inhibitors and Their Uses
    Publication number: 20190262370
    Abstract: Provided herein are methods of treating cancer in a subject. Also provided are methods of treating autoimmune disorders. The methods comprise administering to the subject an effective amount of a CD99 inhibitor.
    Type: Application
    Filed: October 12, 2017
    Publication date: August 29, 2019
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Aykut Üren, Haydar Celik, Jeffrey A. Toretsky
  • Targeting of EWS-FLI1 as anti-tumor therapy
    Patent number: 9045415
    Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: June 2, 2015
    Assignee: Georgetown University
    Inventors: Jeffrey A. Toretsky, Aykut Üren, Milton Lang Brown, Yali Kong
  • sFRP and peptide motifs that interact with sFRP and methods of their use
    Patent number: 8334260
    Abstract: This disclosure relates to a peptide motif and proteins containing the motif that are capable of binding to secreted Frizzled-related protein family members. Accordingly, the disclosure also includes methods of regulating the interaction of sFRP-1 with proteins containing the motif.
    Type: Grant
    Filed: January 24, 2008
    Date of Patent: December 18, 2012
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, St. Vincent's Institute of Medical Research
    Inventors: Jeffrey S. Rubin, Aykut Üren, Brian K. Kay, Bernard Weisblum, Matthew Todd Gillespie, Nicole Joy Horwood
  • Targeting of EWS-FLI1 as anti-tumor therapy
    Patent number: 8232310
    Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: July 31, 2012
    Assignee: Georgetown University
    Inventors: Jeffrey A. Toretsky, Aykut Üren, Milton Lang Brown, Yali Kong
  • Fragments of secreted frizzled related protein
    Patent number: 8158603
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: April 17, 2012
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, University of Massachusetts
    Inventors: Jeffrey S. Rubin, Aykut Üren, Susan Cumberledge, Frieda Reichsman
  • TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY
    Publication number: 20100167994
    Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
    Type: Application
    Filed: March 9, 2010
    Publication date: July 1, 2010
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Jeffrey A. Toretsky, Aykut Üren, Milton Lang Brown, Yali Kong
  • SFRP and peptide motifs that interact with SFRP and methods of their use
    Patent number: 7488710
    Abstract: This disclosure relates to a peptide motif and proteins containing the motif that are capable of binding to secreted Frizzled-related protein family members. Accordingly, the disclosure also includes methods of regulating the interaction of sFRP-1 with proteins containing the motif.
    Type: Grant
    Filed: January 10, 2002
    Date of Patent: February 10, 2009
    Assignees: The United States of America as represented by the Department of Health and Human Services, St. Vincent's Institute of Medical Research
    Inventors: Jeffrey S. Rubin, Aykut Üren, Matthew Todd Gillespie, Nicole Joy Horwood
  • Secreted frizzled related protein fragments
    Patent number: 7223853
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Grant
    Filed: April 28, 2003
    Date of Patent: May 29, 2007
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services., The University of Massachusetts
    Inventors: Frieda Reichsman, Aykut Üren, Jeffrey S. Rubin, Susan Cumberledge