Patents by Inventor Ayman Alawneh

Ayman Alawneh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted Alloxazine Nucleosides and Nucleotides, and Methods of Making Same
    Publication number: 20210317157
    Abstract: The present disclosure includes nucleosides and/or nucleotides comprising an optionally substituted alloxazine (also known as benzo[g]pteridine-2,4(1H,3H)-dione, or isoalloxazine) at the anomeric position.
    Type: Application
    Filed: April 7, 2021
    Publication date: October 14, 2021
    Inventors: Robert D. Kuchta, Ayman Alawneh
  • Synthesis and Biological Activity of Phosphoramidimidate and Phosphoramidate DNA
    Publication number: 20210277047
    Abstract: Oligonucleotides comprising phosphoramidimidate internucleotide linkages, and methods of efficiently synthesizing these oligonucleotides with high yield are provided. These oligonucleotides form duplexes with complementary DNA or RNA that are more stable than natural DNA or DNA/RNA complexes, are active with RNAse H1, and may be transfected into cells using standard lipid reagents. These analogues are therefore useful for numerous therapeutic antisense applications.
    Type: Application
    Filed: June 14, 2019
    Publication date: September 9, 2021
    Inventors: Ayman Alawneh, Marvin Caruthers