Patents by Inventor Aymeric Duclert
Aymeric Duclert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250034641Abstract: The present invention provides composition kits and methods for treating cancer in a human by immunotherapy using successive doses of CAR-T cells with no or reduced anamnestic immune reaction in one individual (P).Type: ApplicationFiled: October 14, 2024Publication date: January 30, 2025Applicant: CELLECTISInventors: David SOURDIVE, Aymeric DUCLERT, Mathieu SIMON, Philippe DUCHATEAU, Alan Marc WILLIAMS, Laurent POIROT
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Patent number: 12144825Abstract: The present invention provides composition kits and methods for treating cancer in a human by immunotherapy using successive doses of CAR-T cells with no or reduced anamnestic immune reaction in one individual (P).Type: GrantFiled: July 2, 2018Date of Patent: November 19, 2024Assignee: CELLECTISInventors: David Sourdive, Aymeric Duclert, Mathieu Simon, Philippe Duchateau, Alan Marc Williams, Laurent Poirot
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Publication number: 20220233588Abstract: The present invention provides composition kits and methods for treating cancer in a human by immunotherapy using successive doses of CAR-T cells with no or reduced anamnestic immune reaction in one individual (P).Type: ApplicationFiled: July 2, 2018Publication date: July 28, 2022Inventors: David SOURDIVE, Aymeric DUCLERT, Mathieu SIMON, Philippe DUCHATEAU, Alan Marc WILLIAMS, Laurent POIROT
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Publication number: 20210017545Abstract: The present invention relates to the field of genome engineering (gene editing). More specifically the invention provides with allele specific TALE-nucleases and methods to operate allele specific gene repair by homologous recombination in primary cells, such as hematopoietic stem cells, blood cells and hepatocytes. These reagents and methods can be used for the genetic treatment of inherited disease, such as sickle cell disease betathalassemia.Type: ApplicationFiled: March 29, 2019Publication date: January 21, 2021Inventors: Alex BOYNE, Brian BUSSER, Philippe DUCHATEAU, Aymeric DUCLERT
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Patent number: 9290748Abstract: The present invention concerns the endonucleases capable of cleaving a target sequence located in a “safe harbor loci”, i.e. a loci allowing safe expression of a transgene. The present invention further concerns the use of such endonucleases for inserting transgenes into a cell, tissue or individual.Type: GrantFiled: February 28, 2011Date of Patent: March 22, 2016Assignee: CellectisInventors: Olivier Danos, Aymeric Duclert
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Publication number: 20130227715Abstract: The present invention concerns the endonucleases capable of cleaving a target sequence located in a “safe harbor loci”, i.e. a loci allowing safe expression of a transgene. The present invention further concerns the use of such endonucleases for inserting transgenes into a cell, tissue or individual.Type: ApplicationFiled: February 28, 2011Publication date: August 29, 2013Applicant: CELLECTISInventors: Olivier Danos, Aymeric Duclert
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Publication number: 20110239319Abstract: The present invention concerns the endonucleases capable of cleaving a target sequence located in a “safe harbor loci”, i.e. a loci allowing safe expression of a transgene. The present invention further concerns the use of such endonucleases for inserting transgenes into a cell, tissue or individual.Type: ApplicationFiled: February 28, 2011Publication date: September 29, 2011Inventors: Olivier DANOS, Aymeric Duclert
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Patent number: 7393663Abstract: The sequences of 5? ESTs derived from mRNAs encoding secreted proteins are disclosed. The 5? ESTs may be to obtain cDNAs and genomic DNAs corresponding to the 5? ESTs. The 5? ESTs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. Upstream regulatory sequences may also be obtained using the 5? ESTs. The 5? ESTs may also be used to design expression vectors and secretion vectors.Type: GrantFiled: July 30, 2003Date of Patent: July 1, 2008Assignee: Serono Genetics Institute S.A.Inventors: Jean-Baptiste Dumas Milne Edwards, Aymeric Duclert, Bruno Lacroix
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Patent number: 7235381Abstract: The sequences of 5? ESTs derived from mRNAs encoding secreted proteins are disclosed. The 5? ESTs may be to obtain cDNAs and genomic DNAs corresponding to the 5? ESTs. The 5? ESTs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. Upstream regulatory sequences may also be obtained using the 5? ESTs. The 5? ESTs may also be used to design expression vectors and secretion vectors.Type: GrantFiled: August 25, 2004Date of Patent: June 26, 2007Assignee: Serono Genetics Institute S.A.Inventors: Jean-Baptiste Dumas Milne Edwards, Aymeric Duclert, Jean-Yves Giordano
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Publication number: 20070027308Abstract: The sequences of 5? ESTs derived from mRNAs encoding secreted proteins are disclosed. The 5? ESTs may be to obtain cDNAs and genomic DNAs corresponding to the 5? ESTs. The 5? ESTs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. Upstream regulatory sequences may also be otained using the 5? ESTs. The 5? ESTs may also be used to design expression vectors and secretion vectors.Type: ApplicationFiled: July 30, 2003Publication date: February 1, 2007Inventors: Jean-Baptiste Milne Edwards, Aymeric Duclert, Bruno Lacroix
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Publication number: 20070009941Abstract: The sequences of extended cDNAs encoding secreted proteins are disclosed. The extended cDNAs can be used to express secreted proteins or portions thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The extended cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The extended cDNAs may also be used to design expression vectors and secretion vectors.Type: ApplicationFiled: June 16, 2006Publication date: January 11, 2007Applicant: Serono Genetics Institute S.A.Inventors: Jean-Baptiste Dumas Milne Edwards, Aymeric Duclert, Lydie Bougueleret
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Publication number: 20060286639Abstract: The sequences of cDNAs encoding secreted proteins are disclosed. The cDNAs can be used to express secreted proteins or fragments thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The cDNAs may also be used to design expression vectors and secretion vectors.Type: ApplicationFiled: June 29, 2006Publication date: December 21, 2006Applicant: SERONO GENETICS INSTITUTE S.A.Inventors: Jean-Baptiste Dumas Milne Edwards, Lydie Bougueleret, Severin Jobert, Catherine Clusel, Aymeric Duclert
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Patent number: 7122644Abstract: The invention provides the genomic sequence of GSSP-2, GSSP-2 cDNAs and GSSP-2 polypeptides. Further the invention provides polynucleotides including biallelic markers derived from the GSSP-2 gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid molecule containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. The invention also concerns methods and compositions for killing neoplastic cells or inhibiting neoplastic cell growth. In particular, the present invention concerns cell proliferation arresting/inhibiting and apoptosis/necrosis inducing compositions and methods for the treatment of tumors. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides.Type: GrantFiled: April 10, 2002Date of Patent: October 17, 2006Assignee: Serono Genetics Institute S.A.Inventors: Frances Yen-Potin, Blake Denison, Aymeric Duclert, Lydie Bougueleret, Catherine Clusel, Jean-Baptiste Dumas Milne Edwards, Bernard Bihain, Barbara Bour, Dana Ebbets-Reed, Luisa Salter-Cid
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Publication number: 20060223142Abstract: The sequences of extended cDNAs encoding secreted proteins are disclosed. The extended cDNAs can be used to express secreted proteins or portions thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The extended cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The extended cDNAs may also be used to design expression vectors and secretion vectors.Type: ApplicationFiled: November 10, 2005Publication date: October 5, 2006Applicant: Serono Genetics Institute S.A.Inventors: Jean-Baptiste Dumas Milne Edwards, Aymeric Duclert, Lydie Bougueleret
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Patent number: 7115416Abstract: The sequences of 5? ESTs derived from mRNAs encoding secreted proteins are disclosed. The 5? ESTs may be to obtain cDNAs and genomic DNAs corresponding to the 5? ESTs. The 5? ESTs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. Upstream regulatory sequences may also be obtained using the 5? ESTs. The 5? ESTs may also be used to design expression vectors and secretion vectors.Type: GrantFiled: March 3, 2004Date of Patent: October 3, 2006Assignee: Serono Genetics Institute S.A.Inventors: Jean-Baptiste Dumas Milne Edwards, Aymeric Duclert, Jean-Yves Giordano
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Publication number: 20060189793Abstract: The invention provides the genomic sequence of GSSP-2, GSSP-2 cDNAs and GSSP-2 polypeptdes. Further the invention provides polynucleotides including biallelic markers derived from the GSSP-2 gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid molecule containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. The invention also concerns methods and compositions for killing neoplastic cells or inhibiting neoplastic cell growth. In particular, the present invention concerns cell proliferation arresting/inhibiting and apoptosis/necrosis inducing compositions and methods for the treatment of tumors. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides.Type: ApplicationFiled: April 27, 2006Publication date: August 24, 2006Applicant: Serono Genetics Institute S.A.Inventors: Frances Yen, Blake Denison, Aymeric Duclert, Lydie Bougueleret, Catherine Clusel, Jean-Baptiste Dumas Milne-Edwards, Bernard Bihain, Barbara Bour, Dana Ebbets-Reed, Luisa Salter-Cid
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Patent number: 7056680Abstract: The sequence of a cDNA encoding Claudin-50 and sequence of Claudin-50 protein are disclosed. The cDNA can be used to express the protein or portions thereof or to obtain antibodies capable of specifically binding to the secreted protein. The cDNA may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The cDNA may also be used to design expression vectors and secretion vectors.Type: GrantFiled: December 10, 2002Date of Patent: June 6, 2006Assignee: Serono Genetics Institute S.A.Inventors: Jean-Baptiste Dumas Milne Edwards, Aymeric Duclert, Lydie Bougueleret
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Publication number: 20060009633Abstract: The sequences of cDNAs encoding secreted proteins are disclosed. The cDNAs can be used to express secreted proteins or fragments thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The cDNAs may also be used to design expression vectors and secretion vectors.Type: ApplicationFiled: October 15, 2001Publication date: January 12, 2006Applicant: GENSET, S.A.Inventors: Jean-Baptiste Dumas Milne Edwards, Lydie Bougueleret, Severin Jobert, Catherine Clusel, Aymeric Duclert
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Patent number: 6936692Abstract: The sequences of extended cDNAs encoding secreted proteins are disclosed. The extended cDNAs can be used to express secreted proteins or portions thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The extended cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The extended cDNAs may also be used to design expression vectors and secretion vectors.Type: GrantFiled: July 11, 2001Date of Patent: August 30, 2005Assignee: Genset, S.A.Inventors: Jean-Baptiste Dumas Milne Edwards, Aymeric Duclert, Lydie Bougueleret
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Publication number: 20050106595Abstract: The sequences of 5? ESTs derived from mRNAs encoding secreted proteins are disclosed. The 5? ESTs may be to obtain cDNAs and genomic DNAs corresponding to the 5? ESTs. The 5? ESTs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. Upstream regulatory sequences may also be obtained using the 5? ESTs. The 5? ESTs may also be used to design expression vectors and secretion vectors.Type: ApplicationFiled: August 25, 2004Publication date: May 19, 2005Applicant: Genset S.A.Inventors: Jean-Baptiste Dumas Milne Edwards, Aymeric Duclert, Jean-Yves Giordano