Patents by Inventor Ayodele O. Ogunkoya

Ayodele O. Ogunkoya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Branched Linkers for Antibody-Drug Conjugates and Methods of Use Thereof
    Publication number: 20240148883
    Abstract: The present disclosure provides antibody-drug conjugate structures. The antibody-drug conjugate structures include a branched linker where two or more payloads per branched linker are attached to a polypeptide (e.g., an antibody). In addition, the disclosure also encompasses compounds and methods for production of such conjugates. In addition, the disclosure also encompasses methods of using the conjugates.
    Type: Application
    Filed: March 2, 2022
    Publication date: May 9, 2024
    Inventors: Stepan Chuprakov, Ayodele O. Ogunkoya, Penelope M. Drake
  • CAMPTOTHECINE ANTIBODY-DRUG CONJUGATES AND METHODS OF USE THEREOF
    Publication number: 20230277676
    Abstract: The present disclosure provides antibody-drug conjugate (ADC) structures, which include a camptothecine or a camptothecine derivative linked to a polypeptide (e.g., an antibody) through a linker. The disclosure also encompasses compounds and methods for production of such conjugates, as well as methods of using the conjugates.
    Type: Application
    Filed: December 22, 2022
    Publication date: September 7, 2023
    Inventors: Stepan Chuprakov, Ayodele O. Ogunkoya, Penelope M. Drake
  • Camptothecine antibody-drug conjugates and methods of use thereof
    Patent number: 11564989
    Abstract: The present disclosure provides antibody-drug conjugate (ADC) structures, which include a camptothecine or a camptothecine derivative linked to a polypeptide (e.g., an antibody) through a linker. The disclosure also encompasses compounds and methods for production of such conjugates, as well as methods of using the conjugates.
    Type: Grant
    Filed: January 13, 2022
    Date of Patent: January 31, 2023
    Assignee: R.P. Scherer Technologies, LLC
    Inventors: Stepan Chuprakov, Ayodele O. Ogunkoya, Penelope M. Drake
  • GLYCOSIDE DUAL-CLEAVAGE LINKERS FOR ANTIBODY-DRUG CONJUGATES
    Publication number: 20220249686
    Abstract: The present disclosure provides antibody-drug conjugate structures, which include a cleavable linker that links the antibody to the drug and has a first enzymatically cleavable moiety and a second enzymatically cleavable moiety which includes a glycoside selected from a galactoside, a glucoside, a mannoside, a fucoside, O-GlcNAc, and O-GalNAc. The disclosure also encompasses compounds and methods for production of such conjugates, as well as methods of using the conjugates.
    Type: Application
    Filed: November 19, 2021
    Publication date: August 11, 2022
    Inventors: Stepan Chuprakov, Ayodele O. Ogunkoya
  • CAMPTOTHECINE ANTIBODY-DRUG CONJUGATES AND METHODS OF USE THEREOF
    Publication number: 20220241423
    Abstract: The present disclosure provides antibody-drug conjugate (ADC) structures, which include a camptothecine or a camptothecine derivative linked to a polypeptide (e.g., an antibody) through a linker. The disclosure also encompasses compounds and methods for production of such conjugates, as well as methods of using the conjugates.
    Type: Application
    Filed: January 13, 2022
    Publication date: August 4, 2022
    Inventors: Stepan Chuprakov, Ayodele O. Ogunkoya, Penelope M. Drake