Abstract: An object is to produce a collagen vitrigel, which has a high film strength even without performing a crosslinking treatment, and is easily produced and processed industrially and mechanically, and is also easy to handle and is highly safe, from collagen, and a purified product thereof. In order to achieve the object, it is directed to a method for producing a collagen vitrigel characterized by gelling collagen with a gelling agent containing an inorganic carbonate and a compound selected from the group consisting of an inorganic chloride and an inorganic phosphate, subsequently vitrifying the obtained collagen gel, and further subjecting the vitrified collagen gel to a hydration treatment; a method for producing a purified collagen vitrigel characterized by desalting, equilibrating, and further drying the collagen vitrigel; and a collagen vitrigel and a purified collagen vitrigel obtained by these methods.

Abstract: The present invention provides a production method of a filament for which a hydrogel having lower strength than a native collagen gel can be used as a raw material. The present invention provides a filament obtained by the above production method and having excellent strength. The production method of the filament includes a step A of irradiating columnar hydrogel with ultraviolet rays; step B of vitrifying the columnar hydrogel after irradiation with the ultraviolet rays to obtain a filamentous hydrogel dried body; and a step C of rehydrating the filamentous hydrogel dried body to obtain a filamentous vitrigel, in this order. The filament is formed of a vitrigel dried body, and to which a hydrophobic solvent is adhered or impregnated.

Abstract: The present invention addresses the problem of providing an artificial skin preparation which requires no suturing or the like when treating a wound area with a dried collagen vitrigel membrane material as an artificial skin, and also is less likely to cause contamination or the like with an exudate, and is free from the risk of secondary damage by replacement thereof.