Patents by Inventor Ayumi Toyoshima

Ayumi Toyoshima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-a non-b hepatitis-specific antigen and its use in hepatitis diagnosis
    Patent number: 5662906
    Abstract: This invention relates to a DNA fragment comprising a base sequence encoding a non-A non-B hepatitis-specific antigen polypeptide, said base sequence being obtained using genetic engineering techniques from non-A non-B hepatitis virus RNA which is isolated directly from blood plasma from non-A non-B hepatitis patients, to an expression vector and a transformant for use in the expression of the DNA fragment, to a single strand DNA sequence for PCR primer, and to use of said polypeptide and said single strand DNA sequence in the detection of the non-A non-B hepatitis virus. The recombinant polypeptide and the single strand DNA sequence for PCR primer make it possible to detect the non-A non-B hepatitis virus with extremely high accuracy.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: September 2, 1997
    Assignee: Tonen Corporation
    Inventors: Noboru Maki, Kenjiro Yamaguchi, Ayumi Toyoshima, Michinori Kohara
  • Non-A non-B hepatitis specific antigen and its use in hepatitis
    Patent number: 5641654
    Abstract: This invention relates to a DNA fragment comprising a base sequence encoding a non-A non-B hepatitis-specific antigen polypeptide, said base sequence being obtained using genetic engineering techniques from non-A non-B hepatitis virus RNA which is isolated directly from blood plasma from non-A non-B hepatitis patients, to an expression vector and a transformant for use in the expression of the DNA fragment, to a single strand DNA sequence for PCR primer, and to use of said polypeptide and said single strand DNA sequence in the detection of the non-A non-B hepatitis virus. The recombinant polypeptide and the single strand DNA sequence for PCR primer make it possible to detect the non-A non-B hepatitis virus with extremely high accuracy.
    Type: Grant
    Filed: June 22, 1993
    Date of Patent: June 24, 1997
    Assignee: Tonen Corporation
    Inventors: Noboru Maki, Kenjiro Yamaguchi, Ayumi Toyoshima, Michinori Kohara