Patents by Inventor Ayush Verma
Ayush Verma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240016736Abstract: Nucleic acid immunisation is achieved by delivering RNA encapsulated within a PEGylated liposome. The RNA encodes an immunogen of interest. The PEG has an average molecular mass above 3 kDa but less than 11 kDa. Thus the invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer comprises at least one lipid which includes a polyethylene glycol moiety, such that polyethylene glycol is present on the liposome's exterior, wherein the average molecular mass of the polyethylene glycol is above 3 kDa but less than 11 kDa; and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases.Type: ApplicationFiled: February 27, 2023Publication date: January 18, 2024Applicant: GLAXOSMITHKLINE BIOLOGICALS SAInventors: Andrew GEALL, Ayush VERMA
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Patent number: 11759422Abstract: Nucleic acid immunisation is achieved by delivering RNA encapsulated within a PEGylated liposome. The RNA encodes an immunogen of interest. The PEG has an average molecular mass of between 1 kDa and 3 kDa. Thus the invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer comprises at least one lipid which includes a polyethylene glycol moiety, such that polyethylene glycol is present on the liposome's exterior, wherein the average molecular mass of the polyethylene glycol is between 1 kDa and 3 kDa; and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases.Type: GrantFiled: April 1, 2020Date of Patent: September 19, 2023Assignee: GLAXOSMITHKLINE BIOLOGICALS SAInventors: Andrew Geall, Ayush Verma
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Publication number: 20220072286Abstract: A device for the delivery of an agent to an intestinal site has a backing element, a mucoadhesive element for adhering the device to the intestinal site, and a reservoir comprising the agent. The mucoadhesive element includes a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20° C. in phosphate buffered saline at pH 6.5.Type: ApplicationFiled: November 12, 2021Publication date: March 10, 2022Inventors: Daniel BONNER, Colin Robert GARDNER, Thomas H. JOZEFIAK, Christopher R. LOOSE, David LUCCHINO, Andrew Craig MILLER, Carlo Giovanni TRAVERSO, Ayush VERMA, Arthur J. COURY, Peter TRAN, John JANTZ
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Publication number: 20210236784Abstract: A device for the delivery of an agent to an intestinal site has a backing element, a mucoadhesive element for adhering the device to the intestinal site, and a reservoir comprising the agent. The mucoadhesive element includes a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20° C. in phosphate buffered saline at pH 6.5.Type: ApplicationFiled: April 19, 2021Publication date: August 5, 2021Inventors: Daniel BONNER, Colin Robert GARDNER, Thomas H. JOZEFIAK, Christopher R. LOOSE, David LUCCHINO, Andrew Craig MILLER, Carlo Giovanni TRAVERSO, Ayush VERMA, Arthur J. COURY, Peter TRAN, John JANTZ
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Publication number: 20200384250Abstract: A device for the delivery of an agent to an intestinal site has a backing element, a mucoadhesive element for adhering the device to the intestinal site, and a reservoir comprising the agent. The mucoadhesive element includes a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20° C. in phosphate buffered saline at pH 6.5.Type: ApplicationFiled: July 31, 2020Publication date: December 10, 2020Inventors: Daniel BONNER, Colin Robert GARDNER, Thomas H. JOZEFIAK, Christopher R. LOOSE, David LUCCHINO, Andrew Craig MILLER, Carlo Giovanni TRAVERSO, Ayush VERMA, Arthur J. COURY, Peter TRAN, John JANTZ
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Publication number: 20200230058Abstract: Nucleic acid immunisation is achieved by delivering RNA encapsulated within a PEGylated liposome. The RNA encodes an immunogen of interest. The PEG has an average molecular mass of between 1 kDa and 3 kDa. Thus the invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer comprises at least one lipid which includes a polyethylene glycol moiety, such that polyethylene glycol is present on the liposome's exterior, wherein the average molecular mass of the polyethylene glycol is between 1 kDa and 3 kDa; and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases.Type: ApplicationFiled: April 1, 2020Publication date: July 23, 2020Applicant: GLAXOSMITHKLINE BIOLOGICALS SAInventors: Andrew GEALL, Ayush VERMA
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Publication number: 20200113830Abstract: Nucleic acid immunisation is achieved by delivering RNA encapsulated within a PEGylated liposome. The RNA encodes an immunogen of interest. The PEG has an average molecular mass above 3 kDa but less than 11 kDa. Thus the invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer comprises at least one lipid which includes a polyethylene glycol moiety, such that polyethylene glycol is present on the liposome's exterior, wherein the average molecular mass of the polyethylene glycol is above 3 kDa but less than 11 kDa; and (ii) the aqueous core includes a RNA which encodes an immunogen.Type: ApplicationFiled: December 16, 2019Publication date: April 16, 2020Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A.Inventors: Andrew GEALL, Ayush VERMA
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Publication number: 20200113831Abstract: Nucleic acid immunisation is achieved by delivering a RNA encapsulated within a liposome comprising a cationic lipid, wherein the liposome and the RNA have a N:P ratio of between 1:1 and 20:1.Type: ApplicationFiled: December 16, 2019Publication date: April 16, 2020Applicant: GLAXOSMITHKLINE BIOLOGICALS SAInventors: Andrew GEALL, Ayush VERMA
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Publication number: 20180193621Abstract: A device for the delivery of an agent to an intestinal site has a backing element, a mucoadhesive element for adhering the device to the intestinal site, and a reservoir comprising the agent. The mucoadhesive element includes a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20° C. in phosphate buffered saline at pH 6.5.Type: ApplicationFiled: June 28, 2016Publication date: July 12, 2018Inventors: Daniel Bonner, Colin R. Gardner, Thomas H. Jozefiak, Christopher R. Loose, David Lucchino, Andrew Craig Miller, Carlo Giovanni Traverso, Ayush Verma, Arthur J. Coury, Peter Tran, John Jantz
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Patent number: 9254265Abstract: Nucleic acid immunization is achieved by delivering RNA encapsulated within a liposome. The RNA encodes an immunogen of interest, and the liposome has a diameter in the range of 60-180 nm, and ideally in the range 80-160 nm. Thus the invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer has a diameter in the range of 60-180 nm; and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunizing subjects against various diseases.Type: GrantFiled: August 31, 2011Date of Patent: February 9, 2016Assignee: NOVARTIS AGInventors: Andrew Geall, Ayush Verma
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Publication number: 20140255472Abstract: The invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer comprises at least one lipid which includes a polyethylene glycol moiety, such that polyethylene glycol is present on the liposome's exterior, wherein the average molecular mass of the polyethylene glycol is above 3 kDa but less than 11 kDa; and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases.Type: ApplicationFiled: August 31, 2012Publication date: September 11, 2014Inventors: Andrew Geall, Ayush Verma
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Publication number: 20140141070Abstract: Nucleic acid immunisation is achieved by delivering a RNA encapsulated within a liposome comprising a cationic lipid, wherein the liposome and the RNA have a N:P ratio of between 1:1 and 20:1.Type: ApplicationFiled: July 6, 2012Publication date: May 22, 2014Inventors: Andrew Geall, Ayush Verma
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Publication number: 20130202684Abstract: Nucleic acid immunisation is achieved by delivering RNA encapsulated within a PEGylated liposome. The RNA encodes an immunogen of interest. The PEG has an average molecular mass of between 1 kDa and 3 kDa. Thus the invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer comprises at least one lipid which includes a polyethylene glycol moiety, such that polyethylene glycol is present on the liposome's exterior, wherein the average molecular mass of the polyethylene glycol is between 1 kDa and 3 kDa; and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases.Type: ApplicationFiled: August 31, 2011Publication date: August 8, 2013Applicant: LichtstrasseInventors: Andrew Geall, Ayush Verma
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Publication number: 20130195969Abstract: Nucleic acid immunisation is achieved by delivering RNA encapsulated within a liposome. The RNA encodes an immunogen of interest, and the liposome has a diameter in the range of 60-180 nm, and ideally in the range 80-160 nm. Thus the invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer has a diameter in the range of 60-180 nm; and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases.Type: ApplicationFiled: August 31, 2011Publication date: August 1, 2013Applicant: NOVARTIS AGInventors: Andrew Geall, Ayush Verma