Patents by Inventor Ayyappan Subbiah

Ayyappan Subbiah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10342797
    Abstract: Disclosed herein are methods and compositions to improve the solubility of therapeutic agents. In one embodiment, a method of improving solubility of a therapeutic agent includes mixing fullerene in a lipid solution to form a lipofullerene mixture, and mixing the therapeutic agent with the lipofullerene mixture.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: July 9, 2019
    Assignee: LivePet, LLC
    Inventors: Ian Mitchell, Daniel David Bensimon, Ayyappan Subbiah, Rajashekharam Malyala
  • Patent number: 10293054
    Abstract: In some embodiments, a lipofullerene-saccharide compound and a method of inhibiting and/or ameliorating metastasis of neoplastic cells using said compound is disclosed herein. The lipofullerene-saccharide compound may be used in therapeutically effective doses to inhibit the metastasis of neoplasms in mammals. In some embodiments, the method may include administering to a subject an effective amount of a pharmaceutically acceptable formulation including a lipofullerene-saccharide compound. In some embodiments, the lipofullerene-saccharide compound may be formed by reacting (e.g., coupling) a lipid and a saccharide with a fullerene. In some embodiments, neoplastic cells may include pancreatic cancer cells, prostate cancer cells, lung cancer cells, breast cancer cells, colon cancer cells, and/or brain cancer cells.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: May 21, 2019
    Assignee: LivePet, LLC
    Inventors: Ian Mitchell, Ayyappan Subbiah, Daniel David Bensimon
  • Publication number: 20180256728
    Abstract: In some embodiments, a lipofullerene-saccharide compound and a method of inhibiting and/or ameliorating metastasis of neoplastic cells using said compound is disclosed herein. The lipofullerene-saccharide compound may be used in therapeutically effective doses to inhibit the metastasis of neoplasms in mammals. In some embodiments, the method may include administering to a subject an effective amount of a pharmaceutically acceptable formulation including a lipofullerene-saccharide compound. In some embodiments, the lipofullerene-saccharide compound may be formed by reacting (e.g., coupling) a lipid and a saccharide with a fullerene. In some embodiments, neoplastic cells may include pancreatic cancer cells, prostate cancer cells, lung cancer cells, breast cancer cells, colon cancer cells, and/or brain cancer cells.
    Type: Application
    Filed: February 23, 2018
    Publication date: September 13, 2018
    Inventors: Ian Mitchell, Ayyappan Subbiah, Daniel David Bensimon
  • Publication number: 20170258917
    Abstract: Disclosed herein are methods and compositions to improve the solubility of therapeutic agents. In one embodiment, a method of improving solubility of a therapeutic agent includes mixing fullerene in a lipid solution to form a lipofullerene mixture, and mixing the therapeutic agent with the lipofullerene mixture.
    Type: Application
    Filed: November 2, 2016
    Publication date: September 14, 2017
    Applicant: Sevengenes Inc
    Inventors: Ayyappan Subbiah, Rajashekharam Malyala
  • Patent number: 9375656
    Abstract: Methods relating to methods for producing a needle coke precursor from slurry oil having low levels of nitrogen and sulfur. Nitrogen-containing compounds are removed by chromatography, followed by hydrotreating at relatively mild conditions that focus on the more easily-removed sulfur-containing compounds while largely preserving aromatic content of the slurry oil. The resulting needle coke precursor can be converted to a premium needle coke in a delayed coking system.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: June 28, 2016
    Assignee: PHILLIPS 66 COMPANY
    Inventors: Ayyappan Subbiah, Tushar V. Choudhary
  • Patent number: 9308243
    Abstract: In some embodiments, a chemical composition may include C60, serrapeptase, or a tetrapeptide. The tetrapeptide may include ALA,GLU,ASP,GLY. In some embodiments, the chemical composition may include a dipeptide. The dipeptide may include carnosine or camatine. In some embodiments, the chemical composition may include at least one lipid. One or more components of the chemical composition may be suspended in and/or dissolved in the at least one lipid. At least one lipid may include olive oil or mussel oil. In some embodiments, a method may include administering to a subject an effective amount of a pharmaceutically acceptable formulation comprising the chemical composition. The method may include inhibiting and/or ameliorating inflammation and/or a malady associated with inflammation. In some embodiments, the subject may include a human or a nonhuman mammal. Nonhuman mammals may include equines, canines, or felines.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: April 12, 2016
    Assignee: LivePet, LLC
    Inventors: Ian Mitchell, Ayyappan Subbiah, Daniel David Bensimon
  • Publication number: 20150258181
    Abstract: In some embodiments, a chemical composition may include C60, serrapeptase, or a tetrapeptide. The tetrapeptide may include ALA,GLU,ASP,GLY. In some embodiments, the chemical composition may include a dipeptide. The dipeptide may include carnosine or camatine. In some embodiments, the chemical composition may include at least one lipid. One or more components of the chemical composition may be suspended in and/or dissolved in the at least one lipid. At least one lipid may include olive oil or mussel oil. In some embodiments, a method may include administering to a subject an effective amount of a pharmaceutically acceptable formulation comprising the chemical composition. The method may include inhibiting and/or ameliorating inflammation and/or a malady associated with inflammation. In some embodiments, the subject may include a human or a nonhuman mammal. Nonhuman mammals may include equines, canines, or felines.
    Type: Application
    Filed: March 12, 2015
    Publication date: September 17, 2015
    Inventors: Ian Mitchell, Ayyappan Subbiah, Daniel David Bensimon
  • Publication number: 20140299510
    Abstract: Methods relating to methods for producing a needle coke precursor from slurry oil having low levels of nitrogen and sulfur. Nitrogen-containing compounds are removed by chromatography, followed by hydrotreating at relatively mild conditions that focus on the more easily-removed sulfur-containing compounds while largely preserving aromatic content of the slurry oil. The resulting needle coke precursor can be converted to a premium needle coke in a delayed coking system.
    Type: Application
    Filed: June 19, 2014
    Publication date: October 9, 2014
    Applicant: PHILLIPS 66 COMPANY
    Inventors: Ayyappan SUBBIAH, Tushar V. CHOUDHARY
  • Patent number: 8834709
    Abstract: A process of producing a light oil stream from slurry oils. The process begins by obtaining slurry oil from a fluid catalytic cracking unit. The slurry oil is then flowed over a fixed bed catalyst, consisting essentially of a non-metal catalyst, to produce a processed slurry oil. The processed slurry oil is then separated by boiling point to separate out the light oil stream.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: September 16, 2014
    Assignee: Phillips 66 Company
    Inventors: Tushar Choudhary, Ayyappan Subbiah
  • Publication number: 20130092600
    Abstract: A process of producing a light oil stream from slurry oils. The process begins by obtaining slurry oil from a fluid catalytic cracking unit. The slurry oil is then flowed over a fixed bed catalyst, consisting essentially of a non-metal catalyst, to produce a processed slurry oil. The processed slurry oil is then separated by boiling point to separate out the light oil stream.
    Type: Application
    Filed: December 16, 2011
    Publication date: April 18, 2013
    Applicant: ConocoPhillips Company
    Inventors: Tushar Choudhary, Ayyappan Subbiah
  • Publication number: 20100176029
    Abstract: Methods and apparatus relate to reducing content of nitrogen-containing compounds within slurry oil using a chromatographic based assembly, which may not affect aromatic content, prior to feeding the slurry oil into a coking system. The slurry oil passes through the chromatographic based assembly to upgrade the slurry oil and make the slurry oil suitable for feedstock in making needle coke. Further, a hydrotreater utilized in combination with the chromatographic based assembly may provide additional upgrading of the slurry oil.
    Type: Application
    Filed: January 9, 2009
    Publication date: July 15, 2010
    Applicant: ConocoPhillips Company
    Inventors: Ayyappan Subbiah, Tushar V. Choudhary
  • Patent number: 6936562
    Abstract: Certain metal-exchanged SUZ-4 zeolites have been prepared that have catalytic activity for the reduction of NOx in the exhaust of a hydrocarbon or alcohol fueled engine operated under fuel lean conditions. Initially the SUZ-4 zeolite contains alkali metal cations such as Li+, Na+, K+ and/or Cs+. These alkali metal cation-containing zeolites are partially exchanged with at least one of copper (II), silver (I), iron (III) or cobalt (II) ions. The resulting partially exchanged SUZ-4 zeolites display such activity and are stable under extreme hydrothermal aging conditions.
    Type: Grant
    Filed: September 4, 2003
    Date of Patent: August 30, 2005
    Assignee: General Motors Corporation
    Inventors: Byong Kwon Cho, Richard J. Blint, Ayyappan Subbiah
  • Publication number: 20040043891
    Abstract: Certain metal-exchanged SUZ-4 zeolites have been prepared that have catalytic activity for the reduction of NOx in the exhaust of a hydrocarbon or alcohol fueled engine operated under fuel lean conditions. Initially the SUZ-4 zeolite contains alkali metal cations such as Li+, Na+, K+ and/or Cs+. These alkali metal cation-containing zeolites are partially exchanged with at least one of copper (II), silver (I), iron (III) or cobalt (II) ions. The resulting partially exchanged SUZ-4 zeolites display such activity and are stable under extreme hydrothermal aging conditions.
    Type: Application
    Filed: September 4, 2003
    Publication date: March 4, 2004
    Applicant: General Motors Corporation
    Inventors: Byong Kwon Cho, Richard J. Blint, Ayyappan Subbiah
  • Patent number: 6645448
    Abstract: Certain metal-exchanged SUZ-4 zeolites have been prepared that have catalytic activity for the reduction of NOx in the exhaust of a hydrocarbon or alcohol fueled engine operated under fuel lean conditions. Initially the SUZ-4 zeolite contains alkali metal cations such as Li+, Na+, K+ and/or Cs+. These alkali metal cation-containing zeolites are partially exchanged with at least one of copper (II), silver (I), iron (III) or cobalt (II) ions. The resulting partially exchanged SUZ-4 zeolites display such activity and are stable under extreme hydrothermal aging conditions.
    Type: Grant
    Filed: October 18, 2001
    Date of Patent: November 11, 2003
    Assignee: General Motors Corporation
    Inventors: Byong Kwon Cho, Richard J. Blint, Ayyappan Subbiah
  • Publication number: 20030077213
    Abstract: Certain metal-exchanged SUZ-4 zeolites have been prepared that have catalytic activity for the reduction of NOx in the exhaust of a hydrocarbon or alcohol fueled engine operated under fuel lean conditions. Initially the SUZ-4 zeolite contains alkali metal cations such as Li+, Na+, K+ and/or Cs+. These alkali metal cation-containing zeolites are partially exchanged with at least one of copper (II), silver (I), iron (III) or cobalt (II) ions. The resulting partially exchanged SUZ-4 zeolites display such activity and are stable under extreme hydrothermal aging conditions.
    Type: Application
    Filed: October 18, 2001
    Publication date: April 24, 2003
    Inventors: Byong Kwon Cho, Richard J. Blint, Ayyappan Subbiah