Abstract: A system and method are provided for a guide system for guiding an interventional medical instrument toward a region of interest (ROI) along a predetermined trajectory path. The guide system comprises a base, an adjustment ring, and a plurality of guide blocks. The adjustment ring is configured to be selectively fixed in one of a plurality of rotational orientations with respect to the base. The plurality of guide blocks are each configured to be selectively fixed in one of a plurality of rotational orientations with respect to the adjustment ring and each include a guide hole. Each of the plurality of guide blocks include at least one of differing angles of trajectory or differing locations of the guide hole from others of the plurality of guide blocks to provide a selectable, predetermined location of the guide hole and angle of trajectory.

Abstract: A thin-film microelectrode array tailored for long-term, minimally invasive cortical recording or stimulation and method are provided. The microelectrode array includes a flexible element that is movable between a first contracted configuration and a second expanded configuration. An array of contacts is provided on the flexible element. The contacts are engagable with a cortical surface with the flexible element in the expanded configuration. A link operatively connects the array of contacts to a control module. The link is capable of transmitting at least one of cortical recordings and cortical stimulation signals thereon.

Abstract: A thin-film microelectrode array tailored for long-term, minimally invasive cortical recording or stimulation and method are provided. The microelectrode array includes a flexible element that is movable between a first contracted configuration and a second expanded configuration. An array of contacts is provided on the flexible element. The contacts are engagable with a cortical surface with the flexible element in the expanded configuration. A link operatively connects the array of contacts to a control module. The link is capable of transmitting at least one of cortical recordings and cortical stimulation signals thereon.

Abstract: A thin-film microelectrode array tailored for long-term, minimally invasive cortical recording or stimulation and method are provided. The microelectrode array includes a flexible element that is movable between a first contracted configuration and a second expanded configuration. An array of contacts is provided on the flexible element. The contacts are engagable with a cortical surface with the flexible element in the expanded configuration. A link operatively connects the array of contacts to a control module. The link is capable of transmitting at least one of cortical recordings and cortical stimulation signals thereon.