Patents by Inventor Azim Abul

Azim Abul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of pralatrexate
    Patent number: 9440979
    Abstract: An improved process for the preparation of Pralatrexate which is less hazardous. The invention further relates to novel intermediates and process thereof useful for the preparation of Pralatrexate. The present invention also relates to a substantially pure Pralatrexate and a process for obtaining the same in high yield.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: September 13, 2016
    Assignee: FRESENIUS KABI ONCOLOGY LIMITED
    Inventors: Saswata Lahiri, Nitin Gupta, Hemant Kumar Singh, Nilendu Panda, Vishal Handa, Azim Abul, Chandan Kumar Gupta, Sunil Sanghani, Ghanashyam Madhukar Sonavane
  • CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION
    Publication number: 20150297738
    Abstract: The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS?(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS? is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.
    Type: Application
    Filed: June 29, 2015
    Publication date: October 22, 2015
    Inventors: Helmut Knoller, Dominik Heckmann, Frank Hacket, Norbert Zander, Frank Nocken, Saswata Lahiri, Nitin Gupta, Sunil Sanghani, Azim Abul, Hemant Kumar Singh, Sandeep Grewal, Sandeep Kaur
  • IMPROVED PROCESS FOR THE PREPARATION OF PRALATREXATE
    Publication number: 20150183789
    Abstract: An improved process for the preparation of Pralatrexate which is less hazardous. The invention further relates to novel intermediates and process thereof useful for the preparation of Pralatrexate. The present invention also relates to a substantially pure Pralatrexate and a process for obtaining the same in high yield.
    Type: Application
    Filed: July 18, 2013
    Publication date: July 2, 2015
    Applicant: Fresenius Kabi Oncology Limited
    Inventors: Saswata Lahiri, Nitin Gupta, Hemant Kumar Singh, Nilendu Panda, Vishal Handa, Azim Abul, Chandan Kumar Gupta, Sunil Sanghani, Ghanashyam Madhukar Sonavane
  • CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION
    Publication number: 20140088298
    Abstract: The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxy-yalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS?(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS? is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.
    Type: Application
    Filed: July 11, 2011
    Publication date: March 27, 2014
    Applicant: Fresenius Kabi Deutschland GmbH
    Inventors: Helmut Knoller, Dominik Heckmann, Frank Hacket, Norbert Zander, Frank Nocken, Saswata Lahiri, Nitin Gupta, Sunil Sanghani, Azim Abul, Hemant Kumar Singh, Sandeep Grewal, Sandeep Kaur
  • CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION
    Publication number: 20140073779
    Abstract: The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS?(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS? is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.
    Type: Application
    Filed: July 11, 2011
    Publication date: March 13, 2014
    Applicant: Fresenius Kabi Deutschland GmbH
    Inventors: Helmut Knoller, Dominik Heckmann, Frank Hacket, Norbert Zander, Frank Nocken, Saswata Lahiri, Nitin Gupta, Sunil Sanghani, Azim Abul, Hemant Kumar Singh, Sandeep Grewal, Sandeep Kaur
  • CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION
    Publication number: 20130211060
    Abstract: The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxy-yalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS?(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS? is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.
    Type: Application
    Filed: July 11, 2011
    Publication date: August 15, 2013
    Applicant: Fresenius Kabi Deutschland GmbH
    Inventors: Helmut Knoller, Dominik Heckmann, Frank Hacker, Norbert Zander, Frank Nocken, Saswata Lahiri, Nitin Gupta, Sunil Sanghani, Azim Abul, Hemant Kumar Singh, Sandeep Grewal, Sandeep Kaur
  • CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION
    Publication number: 20130184455
    Abstract: The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS?(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS? is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.
    Type: Application
    Filed: July 11, 2011
    Publication date: July 18, 2013
    Applicant: Fresenius Kabi Deutschland GmbH
    Inventors: Helmut Knoller, Dominik Heckmann, Frank Hacket, Norbert Zander, Frank Nocken, Saswata Lahiri, Nitin Gupta, Sunil Sanghani, Azim Abul, Hemant Kumar Singh, Sandeep Grewal, Sandeep Kaur