Patents by Inventor Aziz Ghahary

Aziz Ghahary has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION OF KYNURENINE AND ANTIGEN PRESENTING CELLS (APC) AS THERAPEUTICS AND METHODS FOR THEIR USE IN IMMUNE MODULATION
    Publication number: 20230414550
    Abstract: This invention provides combinations of kynurenine and antigen presenting cells (APC) for modulating immune tolerance, wherein the combinations may be used to modulate an autoimmune response, which may be of use in the treatment of type 1 diabetes (T1D) or alopecia areata (AA). Uses of kynurenine and antigen presenting cells (APC) as an immune modulator for the treatment of T1D or AA are also provided.
    Type: Application
    Filed: August 13, 2023
    Publication date: December 28, 2023
    Inventors: Aziz GHAHARY, Reza B. JALILI, Ruhangiz T. KILANI, Yunyuan LI
  • Dissolved Protein Arthritis Markers
    Publication number: 20230366892
    Abstract: Methods and kits for diagnosing arthritis are provided. The methods may involve detection of 14-3-3 eta or gamma proteins in a sera or synovial fluid sample.
    Type: Application
    Filed: June 20, 2023
    Publication date: November 16, 2023
    Inventors: Aziz GHAHARY, Wolodymyr Walter Peter MAKSYMOWYCH, Ruhangiz Taghi KILANI
  • Dissolved protein arthritis markers
    Patent number: 11686737
    Abstract: Methods and kits for diagnosing arthritis are provided. The methods may involve detection of 14-3-3 eta or gamma proteins in a sera or synovial fluid sample.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: June 27, 2023
    Inventors: Aziz Ghahary, Wolodymyr Walter Peter Maksymowych, Ruhangiz Taghi Kilani
  • Dissolved Protein Arthritis Markers
    Publication number: 20210055308
    Abstract: Methods and kits for diagnosing arthritis are provided. The methods may involve detection of 14-3-3 eta or gamma proteins in a sera or synovial fluid sample.
    Type: Application
    Filed: May 6, 2020
    Publication date: February 25, 2021
    Inventors: Aziz GHAHARY, Wolodymyr Walter Peter MAKSYMOWYCH, Ruhangiz Taghi KILANI
  • Engineered tissue substitute system
    Patent number: 10865811
    Abstract: Compositions and methods of preparation and use are provided for an engineered tissue substitute system comprising collagen, glycosaminoglycan and hydrogel in a cross-linked matrix. The compositions may be further lyophilized and reconstituted with a physiological fluid prior to use in methods, such as in the treatment of wounds, tissue engineering and cell transplantation.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: December 15, 2020
    Assignee: The University of British Columbia
    Inventors: Aziz Ghahary, Ryan Hartwell
  • WOUND COVERING FOR WOUND MONITORING AND THERAPEUTIC AGENT DELIVERY
    Publication number: 20200188180
    Abstract: A wound covering includes a flexible main body, and a sensor element incorporated into the main body. The sensor element includes a mesh formed from a plurality of fibers, and is configured to undergo a change in appearance in response to a change in a parameter associated with wound exudate. The wound covering further includes a supply of therapeutic agent configured to diffuse therapeutic agent from the wound covering into a wound when the wound covering is placed on a wound.
    Type: Application
    Filed: May 17, 2018
    Publication date: June 18, 2020
    Applicant: UVic Industry Partnerships Inc.
    Inventors: Mohsen Akbari, Bahram Mirani, Aziz Ghahary, Mohammad A. Siddiqui
  • Dissolved protein arthritis markers
    Patent number: 10677804
    Abstract: Methods and kits for diagnosing arthritis are provided. The methods may involve detection of 14-3-3 eta or gamma proteins in a sera or synovial fluid sample.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: June 9, 2020
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Aziz Ghahary, Wolodymyr Walter Peter Maksymowych, Ruhangiz Taghi Kilani
  • 14-3-3 Antagonists for the Prevention and Treatment of Arthritis
    Publication number: 20200157195
    Abstract: Methods for treating arthritis comprising 14-3-3 antagonists that are capable of specifically binding to extracellularly localized 14-3-3 eta and/or 14-3-3 gamma protein isoforms are provided. In preferred embodiments, the 14-3-3 antagonist is an inhibitory peptide or an anti-14-3-3 antibody. The 14-3-3 antagonists are also formulated in a pharmaceutical compositoin and used in a method for reducing matrix metalloprotease (MMP) expression in the synovial fluid of a patient, wherein the MMP is MMP-1 or MMP-3.
    Type: Application
    Filed: July 31, 2019
    Publication date: May 21, 2020
    Inventors: Anthony MAROTTA, Aziz GHAHARY, Walter Wolodymyr Peter MAKSYMOWYCH, Ruhangiz KILANI
  • ENGINEERED TISSUE SUBSTITUTE SYSTEM
    Publication number: 20190010963
    Abstract: Compositions and methods of preparation and use are provided for an engineered tissue substitute system comprising collagen, glycosaminoglycan and hydrogel in a cross-linked matrix. The compositions may be further lyophilized and reconstituted with a physiological fluid prior to use in methods, such as in the treatment of wounds, tissue engineering and cell transplantation.
    Type: Application
    Filed: February 3, 2016
    Publication date: January 10, 2019
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Aziz Ghahary, Ryan Hartwell
  • ENGINEERED TISSUE SUBSTITUTE SYSTEM
    Publication number: 20180258960
    Abstract: The present invention is a new and improved bladder for use with a piston accumulator apparatus, system and method of using same that provides a dispersion tube in the bladder to allow to be communicated under a vacuum from the bladder to the accumulator seawater chamber and back again.
    Type: Application
    Filed: February 3, 2016
    Publication date: September 13, 2018
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Aziz Ghahary, Ryan Hartwell
  • Dissolved Protein Arthritis Markers
    Publication number: 20180095095
    Abstract: Methods and kits for diagnosing arthritis are provided. The methods may involve detection of 14-3-3 eta or gamma proteins in a sera or synovial fluid sample.
    Type: Application
    Filed: October 16, 2017
    Publication date: April 5, 2018
    Inventors: Aziz GHAHARY, Wolodymyr Walter Peter MAKSYMOWYCH, Ruhangiz Taghi KILANI
  • ENGINEERED TISSUE SUBSTITUTE SYSTEM
    Publication number: 20180031005
    Abstract: The present invention is a new and improved bladder for use with a piston accumulator apparatus, system and method of using same that provides a dispersion tube in the bladder to allow to be communicated under a vacuum from the bladder to the accumulator seawater chamber and back again.
    Type: Application
    Filed: April 7, 2016
    Publication date: February 1, 2018
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Aziz Ghahary, Ryan Hartwell
  • Dissolved protein arthritis markers
    Patent number: 9791458
    Abstract: Methods and kits for diagnosing arthritis are provided. The methods may involve detection of 14-3-3 eta or gamma proteins in a sera or synovial fluid sample.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: October 17, 2017
    Assignee: UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Aziz Ghahary, Wolodymyr Walter Peter Maksymowych, Ruhangiz Taghi Kilani
  • Anti-fibrogenic compounds, methods and uses thereof
    Patent number: 9737523
    Abstract: Presented herein are methods for treatment of diseases or conditions related to fibrosis. Compounds, or pharmaceutically acceptable salts thereof or pharmaceutical compositions thereof provide for the treatment of diseases or conditions related to fibrosis.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: August 22, 2017
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Aziz Ghahary, Yunyuan Li, Ruhangiz T. Kilani, Ryan Hartwell
  • A COMBINATION OF KYNURENINE AND ANTIGEN PRESENTING CELLS (APC) AS THERAPEUTICS AND METHODS FOR THEIR USE IN IMMUNE MODULATION
    Publication number: 20170209401
    Abstract: This invention provides combinations of kynurenine and antigen presenting cells (APC) for modulating immune tolerance, wherein the combinations may be used to modulate an autoimmune response, which may be of use in the treatment of Type 1 Diabetes (T1D) or alopecia areata (AA). Uses of kynurenine and antigen presenting cells (APC) as an immune modulator for the treatment of T1D or AA are also provided.
    Type: Application
    Filed: September 25, 2015
    Publication date: July 27, 2017
    Inventors: Aziz GHAHARY, Reza B. JALILI, Runhangiz T. KILANI, Yunyuan LI
  • 14-3-3 Antagonists for the Prevention and Treatment of Arthritis
    Publication number: 20160185842
    Abstract: The invention provides compositions and methods for treating arthritis.
    Type: Application
    Filed: October 1, 2015
    Publication date: June 30, 2016
    Inventors: Anthony MAROTTA, Aziz GHAHARY, Walter Wolodymyr Peter MAKSYMOWYCH, Ruhangiz KILANI
  • Anti-Fibrogenic Compounds, Methods and Uses Thereof
    Publication number: 20160120857
    Abstract: Presented herein are methods for treatment of diseases or conditions related to fibrosis. Compounds, or pharmaceutically acceptable salts thereof or pharmaceutical compositions thereof provide for the treatment of diseases or conditions related to fibrosis.
    Type: Application
    Filed: June 4, 2014
    Publication date: May 5, 2016
    Inventors: Aziz Ghahary, Yunyuan Li, Ruhangiz T. Kilani, Ryan Hartwell
  • Dissolved Protein Arthritis Markers
    Publication number: 20120003665
    Abstract: Methods and kits for diagnosing arthritis are provided. The methods may involve detection of 14-3-3 eta or gamma proteins in a sera or synovial fluid sample.
    Type: Application
    Filed: December 14, 2009
    Publication date: January 5, 2012
    Inventors: AZIZ GHAHARY, WOLODYMYR WALTER PETER MAKSYMOWYCH, RUHANGIZ TAGHI KILANI
  • 14-3-3 Antagonists for the Prevention and Treatment of Arthritis
    Publication number: 20110027269
    Abstract: Methods for treating arthritis comprising 14-3-3 antagonists that are capable of specifically binding to extracellularly localized 14-3-3 eta and/or 14-3-3 gamma protein isoforms are provided. In preferred embodiments, the 14-3-3 antagonist is an inhibitory peptide or an anti-14-3-3 antibody. The 14-3-3 antagonists are also formulated in a pharmaceutical composition and used in a method for reducing matrix metalloprotease (MMP) expression in the synovial fluid of a patient, wherein the MMP is MMP-1 or MMP-3.
    Type: Application
    Filed: November 26, 2008
    Publication date: February 3, 2011
    Inventors: Anthony Marrotta, Aziz Ghahary, Walter Wolodmyr Peter Maksy mowych, Ruhangiz Kilani