Patents by Inventor Azorides R. Morales
Azorides R. Morales has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8288168Abstract: Improved systems and methods for tissue processing are described here. The chemical process and the construction of the apparatus are simplified by using only two different solutions in two separate reaction modules. They are compatible with processing of tissue specimens for genetic analysis, histology, in situ antibody binding and hybridization, archival preservation of morphology and nucleic acids, and combinations thereof.Type: GrantFiled: November 20, 2008Date of Patent: October 16, 2012Assignee: The University of MiamiInventor: Azorides R. Morales
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Publication number: 20110008884Abstract: A pathology grossing tool and board are provided for the preparation from a gross tissue of a uniformly thin tissue specimen, which is suitable for processing for histology, histochemistry, antibody binding, genetic analysis, or the like. A tissue cassette for receiving the tissue sample, providing a flat-cutting surface along its upper edge, and holding the thin tissue specimen is also provided. Methods for their use are provided.Type: ApplicationFiled: August 26, 2009Publication date: January 13, 2011Inventor: Azorides R. Morales
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Publication number: 20090136992Abstract: Improved systems and methods for tissue processing are described here. The chemical process and the construction of the apparatus are simplified by using only two different solutions in two separate reaction modules. They are compatible with processing of tissue specimens for genetic analysis, histology, in situ antibody binding and hybridization, archival preservation of morphology and nucleic acids, and combinations thereof.Type: ApplicationFiled: November 20, 2008Publication date: May 28, 2009Applicant: The University of MiamiInventor: Azorides R. MORALES
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Patent number: 7526987Abstract: A tool for holding tissue to be sampled in place to allow tissue samples of a prescribed thickness to be prepared from the held tissue. The tool includes at least one tine array for engaging and holding the tissue. First and second tine arrays may advantageously be provided to define a slice thickness therebetween. In addition, or in the alternative, the tines of the tine array are mutually spaced apart by different distances to effectively hold the tissue and to define prescribed tissue sample lengths.Type: GrantFiled: April 12, 2007Date of Patent: May 5, 2009Assignee: The University of MiamiInventor: Azorides R. Morales
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Patent number: 7470401Abstract: Improved systems and methods for tissue processing are described here. The chemical process and the construction of the apparatus are simplified by using only two different solutions in two separate reaction modules. They are compatible with processing of tissue specimens for genetic analysis, histology, in situ antibody binding and hybridization, archival preservation of morphology and nucleic acids, and combinations thereof.Type: GrantFiled: October 25, 2004Date of Patent: December 30, 2008Assignee: The University of MiamiInventor: Azorides R. Morales
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Patent number: 7219884Abstract: A tool for holding tissue to be sampled in place to allow tissue samples of a prescribed thickness to be prepared from the held tissue. The tool includes at least one tine array for engaging and holding the tissue. First and second tine arrays may advantageously be provided to define a slice thickness therebetween. In addition, or in the alternative, the tines of the tine array are mutually spaced apart by different distances to effectively hold the tissue and to define prescribed tissue sample lengths.Type: GrantFiled: October 1, 2002Date of Patent: May 22, 2007Assignee: The University of MiamiInventor: Azorides R. Morales
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Patent number: 7138226Abstract: A solution for preservation and/or storage of a cell or tissue is described. This simple nonaqueous composition can have 10% polyethylene glycol and 90% methanol. It can be used at room temperature. Special chemicals, equipment, and techniques are not needed. Tissue preserved with and/or stored in the solution can be processed for cytology or histology, including chemical staining and/or antibody binding, by a variety of methods; antigen, DNA, and RNA can be extracted from processed tissue in high yield and with minimal or no degradation. Advantages of the solution include: economy and safety, easy access to archival material, and compatibility with both cellular and genetic analyses. The use and manufacture of the solution are also described.Type: GrantFiled: May 10, 2002Date of Patent: November 21, 2006Assignee: The University of MiamiInventors: Vladimir Vincek, Mehdi Nassiri, Mehrdad Nadji, Azorides R. Morales
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Patent number: 6793890Abstract: An improved microwave unit and tissue processor system incorporating the unit are provided for use in rapid tissue processing. The microwave unit may be comprised of an energy source, a waveguide transmitting the microwave energy to a reaction chamber, and the reaction chamber being adapted to process tissue specimens for histology. The unit provides gentle and uniform heating, with minimal heat loss and escape of volatile chemicals. The system may be operated continuously and/or batchwise, by manual operation or automatically. The automated system may be operated with continuous throughput to obtain the advantages of the invention such as, for example, rapid processing under two hours and/or preservation of cell structure and tissue architecture.Type: GrantFiled: December 14, 2000Date of Patent: September 21, 2004Assignee: The University of MiamiInventors: Azorides R. Morales, Ervin Essenfeld, Harold Essenfeld, Harold D. Kimrey
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Publication number: 20040061269Abstract: A tool for holding tissue to be sampled in place to allow tissue samples of a prescribed thickness to be prepared from the held tissue. The tool includes at least one tine array for engaging and holding the tissue. First and second tine arrays may advantageously be provided to define a slice thickness therebetween. In addition, or in the alternative, the tines of the tine array are mutually spaced apart by different distances to effectively hold the tissue and to define prescribed tissue sample lengths.Type: ApplicationFiled: October 1, 2002Publication date: April 1, 2004Inventor: Azorides R. Morales
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Publication number: 20030211452Abstract: A solution for preservation and/or storage of a cell or tissue is described. This simple nonaqueous composition can have 10% polyethylene glycol and 90% methanol. It can be used at room temperature. Special chemicals, equipment, and techniques are not needed. Tissue preserved with and/or stored in the solution can be processed for cytology or histology, including chemical staining and/or antibody binding, by a variety of methods; antigen, DNA, and RNA can be extracted from processed tissue in high yield and with minimal or no degradation. Advantages of the solution include: economy and safety, easy access to archival material, and compatibility with both cellular and genetic analyses. The use and manufacture of the solution are also described.Type: ApplicationFiled: May 10, 2002Publication date: November 13, 2003Inventors: Vladimir Vincek, Mehdi Nassiri, Mehrdad Nadji, Azorides R. Morales
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Patent number: 6513803Abstract: A grossing board for preparing gross tissue samples having relatively uniform thickness features one or more tissue-receiving depressions and one or more knife-guiding members. The bottom surface of a tissue-receiving depression is essentially parallel to the upper, cutting surface of the grossing board, and the knife-guiding members are configured to guide the pathologist's knife so as to ensure cuts that are parallel to the bottom surface of the tissue-receiving depression, thereby yielding gross tissue samples of desired reproducible, uniform thickness.Type: GrantFiled: June 8, 2001Date of Patent: February 4, 2003Assignee: The University of MiamiInventors: Azorides R. Morales, Ervin Essenfeld, Harold Essenfeld
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Publication number: 20010051365Abstract: An improved microwave unit and tissue processor system incorporating the unit are provided for use in rapid tissue processing. The microwave unit may be comprised of an energy source, a waveguide transmitting the microwave energy to a reaction chamber, and the reaction chamber being adapted to process tissue specimens for histology. The unit provides gentle and uniform heating, with minimal heat loss and escape of volatile chemicals. The system may be operated continuously and/or batchwise, by manual operation or automatically. The automated system may be operated with continuous throughput to obtain the advantages of the invention such as, for example, rapid processing under two hours and/or preservation of cell structure and tissue architecture.Type: ApplicationFiled: December 14, 2000Publication date: December 13, 2001Inventors: Azorides R. Morales, Ervin Essenfeld, Harold Essenfeld, Harold D. Kimrey
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Publication number: 20010043884Abstract: An improved microwave unit and system incorporating the unit are provided for use in tissue processing and other chemical reactions. The microwave unit is comprised of an energy source, a wavguide transmitting the microwave energy to a reaction chamber, and the reaction chamber being adapted to perform the desired chemical reaction. The unit provides gentle and uniform heating, with minimal heat loss and escape of volatile chemicals. The system may be operated continuously or batchwise, by manual operation or automatically. Preferably, an automated system is operated with continuous throughput using a robotic armature to obtain the advantages of the invention.Type: ApplicationFiled: December 14, 2000Publication date: November 22, 2001Inventors: Ervin Essenfeld, Harold Essenfeld, Ali R. Shahin, Harold D. Kimrey, Azorides R. Morales