Patents by Inventor Azucena C. Hen

Azucena C. Hen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 1-[3-acetylthio-2(s)-methylpropanoyl]-l-proline
    Patent number: 5387697
    Abstract: The intermediate 1-[3-acetylthio-2(s)-methylpropanoyl]-1-proline is prepared by reacting L-proline with (R)-3-acetylthio-2-methyl propanoyl chloride at 0-5.degree. C., with pH controlled at 7.5-8.5, using 2.5M potassium hydroxide and potassium phosphate buffer, which gives >97% pure material after crystallizing from the reaction mixture.
    Type: Grant
    Filed: June 13, 1994
    Date of Patent: February 7, 1995
    Assignee: Merck & Co., Inc.
    Inventor: Azucena C. Hen