Patents by Inventor Azuma Nishio
Azuma Nishio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9480746Abstract: Provided is a means for stably storing a pharmaceutical composition comprising a compound represented by the General Formula (I) below and/or a salt thereof, and for providing the pharmaceutical composition to the market. A resin container colored with a color having a hue (H) within the range of 7.0Y to 9.99Y or 7.0YR to 9.99YR, value (V) within the range of 1.0 to 6.0, and chroma (C) within the range of 0.5 to 7.5, according to Munsell color coordinates, is filled with a pharmaceutical composition comprising a compound represented by the General Formula (I) and/or a salt thereof, to store the pharmaceutical composition.Type: GrantFiled: April 21, 2014Date of Patent: November 1, 2016Assignees: POLA PHARMA INC., NIHON NOHYAKU CO., LTD.Inventors: Hirokazu Kobayashi, Madoka Ito, Azuma Nishio
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Publication number: 20150297448Abstract: Provided is a means for stably storing a pharmaceutical composition comprising a compound represented by the General Formula (I) below and/or a salt thereof, and for providing the pharmaceutical composition to the market. A resin container colored with a color having a hue (H) within the range of 7.0Y to 9.99Y or 7.0YR to 9.99YR, value (V) within the range of 1.0 to 6.0, and chroma (C) within the range of 0.5 to 7.5, according to Munsell color coordinates, is filled with a pharmaceutical composition comprising a compound represented by the General Formula (I) and/or a salt thereof, to store the pharmaceutical composition.Type: ApplicationFiled: April 21, 2014Publication date: October 22, 2015Applicants: POLA PHARMA INC., NIHON NOHYAKU CO., LTD.Inventors: Hirokazu KOBAYASHI, Madoka ITO, Azuma NISHIO
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Patent number: 8541459Abstract: To provide a pharmaceutical composition which can enhance the storage stability of 1-(1-hydroxymethyl-2,3-dihydroxypropyloxymethyl)-2-nitroimidazole without impairing the effect of the compound. The pharmaceutical composition includes 1-(1-hydroxymethyl-2,3-dihydroxypropyloxymethyl)-2-nitroimidazole, which is represented by formula (1): and a compound having chelating ability.Type: GrantFiled: January 17, 2008Date of Patent: September 24, 2013Assignee: Pola Pharma Inc.Inventors: Yasushi Murakami, Naoko Kobayashi, Azuma Nishio, Nobuo Kubota
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Patent number: 8450356Abstract: To provide a pharmaceutical composition which can enhance the storage stability of 1-(1-hydroxymethyl-2,3-dihydroxypropyloxymethyl)-2-nitroimidazole without impairing the effect of the compound. The pharmaceutical composition includes 1-(1-hydroxymethyl-2,3-dihydroxypropyloxymethyl)-2-nitroimidazole, which is represented by formula (1): and a compound having chelating ability.Type: GrantFiled: January 31, 2012Date of Patent: May 28, 2013Assignee: Pola Pharma Inc.Inventors: Yasushi Murakami, Naoko Kobayashi, Azuma Nishio, Nobuo Kubota
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Patent number: 8420687Abstract: To provide a pharmaceutical composition which can enhance the storage stability of 1-(1-hydroxymethyl-2,3-dihydroxypropyloxymethyl)-2-nitroimidazole without impairing the effect of the compound. The pharmaceutical composition includes 1-(1-hydroxymethyl-2,3-dihydroxypropyloxymethyl)-2-nitroimidazole, which is represented by formula (1): and a compound having chelating ability.Type: GrantFiled: January 31, 2012Date of Patent: April 16, 2013Assignee: Pola Pharma Inc.Inventors: Yasushi Murakami, Naoko Kobayashi, Azuma Nishio, Nobuo Kubota
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Patent number: 8258165Abstract: To provide a pharmaceutical composition containing a 2-nitroimidazole derivative, which has high solubility in an aqueous carrier and high stability. The pharmaceutical composition is characterized by containing 1-(1-hydroxymethyl-2,3-dihydroxypropyl)oxymethyl-2-nitroimidazole and creatinine, and containing creatinine of 0.001 to 1 part by mass with respect to 1 part by mass of 1-(1-hydroxymethyl-2,3-dihydroxypropyl)oxymethyl-2-nitroimidazole.Type: GrantFiled: April 16, 2008Date of Patent: September 4, 2012Assignee: Pola Pharma Inc.Inventors: Yasushi Murakami, Naoko Kobayashi, Azuma Nishio, Nobuo Kubota
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Patent number: 8258166Abstract: A Cancer radiotherapeutic method using 1-(1-hydroxymethyl-2,3-dihydroxypropyl)oxymethyl-2-nitroimidazole (compound (i), and creatinine in an amount of 0.001 to part by mass with respect to 1 part by mass of compound (1); and irradiation.Type: GrantFiled: February 3, 2012Date of Patent: September 4, 2012Assignee: Pola Pharma Inc.Inventors: Yasushi Murakami, Naoko Kobayashi, Azuma Nishio, Nobuo Kubota
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Patent number: 8202898Abstract: To provide a pharmaceutical composition containing a 2-nitroimidazole derivative, which has high solubility in an aqueous carrier and high stability. The pharmaceutical composition is characterized by containing 1-(1-hydroxymethyl-2,3-dihydroxypropyl)oxymethyl-2-nitroimidazole and creatinine, and containing creatinine of 0.001 to 1 part by mass with respect to 1 part by mass of 1-(1-hydroxymethyl-2,3-dihydroxypropyl)oxymethyl-2-nitroimidazole.Type: GrantFiled: February 3, 2012Date of Patent: June 19, 2012Assignee: Pola Pharma Inc.Inventors: Yasushi Murakami, Naoko Kobayashi, Azuma Nishio, Nobuo Kubota
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Publication number: 20120136160Abstract: To provide a pharmaceutical composition containing a 2-nitroimidazole derivative, which has high solubility in an aqueous carrier and high stability. The pharmaceutical composition is characterized by containing 1-(1-hydroxymethyl-2,3-dihydroxypropyl)oxymethyl-2-nitroimidazole and creatinine, and containing creatinine of 0.001 to 1 part by mass with respect to 1 part by mass of 1-(1-hydroxymethyl-2,3-dihydroxypropyl)oxymethyl-2-nitroimidazole.Type: ApplicationFiled: February 3, 2012Publication date: May 31, 2012Applicant: POLA PHARMA INC.Inventors: Yasushi Murakami, Naoko Kobayashi, Azuma Nishio, Nobuo Kubota
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Publication number: 20120136295Abstract: To provide a pharmaceutical composition containing a 2-nitroimidazole derivative, which has high solubility in an aqueous carrier and high stability. The pharmaceutical composition is characterized by containing 1-(1-hydroxymethyl-2,3-dihydroxypropyl)oxymethyl-2-nitroimidazole and creatinine, and containing creatinine of 0.001 to 1 part by mass with respect to 1 part by mass of 1-(1-hydroxymethyl-2,3-dihydroxypropyl)oxymethyl-2-nitroimidazole.Type: ApplicationFiled: February 3, 2012Publication date: May 31, 2012Applicant: POLA PHARMA INC.Inventors: Yasushi MURAKAMI, Naoko Kobayashi, Azuma Nishio, Nobuo Kubota
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Publication number: 20120129905Abstract: To provide a pharmaceutical composition which can enhance the storage stability of 1-(1-hydroxymethyl-2,3-dihydroxypropyloxymethyl)-2-nitroimidazole without impairing the effect of the compound. The pharmaceutical composition includes 1-(1-hydroxymethyl-2,3-dihydroxypropyloxymethyl)-2-nitroimidazole, which is represented by formula (1): and a compound having chelating ability.Type: ApplicationFiled: January 31, 2012Publication date: May 24, 2012Applicant: POLA PHARMA INC.Inventors: Yasushi MURAKAMI, Naoko Kobayashi, Azuma Nishio, Nobuo Kubota
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Publication number: 20120130148Abstract: To provide a pharmaceutical composition which can enhance the storage stability of 1-(1-hydroxymethyl-2,3-dihydroxypropyloxymethyl)-2-nitroimidazole without impairing the effect of the compound. The pharmaceutical composition includes 1-(1-hydroxymethyl-2,3-dihydroxypropyloxymethyl)-2-nitroimidazole, which is represented by formula (1): and a compound having chelating ability.Type: ApplicationFiled: January 31, 2012Publication date: May 24, 2012Applicant: POLA PHARMA INC.Inventors: Yasushi Murakami, Naoko Kobayashi, Azuma Nishio, Nobuo Kubota
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Patent number: 8030338Abstract: It is an object to provide a method for producing a 2-nitroimidazole derivative having an acyclic sugar chain in a side chain, which is suitable for production of a derivative having a radioisotope. A method for producing 1-(1-benzoyloxymethyl-2-hydroxyethyl)oxymethyl-2-nitroimidazole, characterized by reacting glycerin with a benzoylating agent to obtain 1-O-benzoylglycerin, reacting 1-O-benzoylglycerin with dimethoxymethane in the presence of a dehydrating agent to obtain 4-benzoyloxymethyl-1,3-dioxolane, and then reacting this product with 2-nitroimidazole or 2-nitro-1-trialkylsilylimidazole in the presence of a Lewis acid.Type: GrantFiled: January 17, 2008Date of Patent: October 4, 2011Assignee: Pola Pharma Inc.Inventor: Azuma Nishio
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Publication number: 20100130576Abstract: To provide a pharmaceutical composition containing a 2-nitroimidazole derivative, which has high solubility in an aqueous carrier and high stability. The pharmaceutical composition is characterized by containing 1-(1-hydroxymethyl-2,3-dihydroxypropyl)oxymethyl-2-nitroimidazole and creatinine, and containing creatinine of 0.001 to 1 part by mass with respect to 1 part by mass of 1-(1-hydroxymethyl-2,3-dihydroxypropyl)oxymethyl-2-nitroimidazole.Type: ApplicationFiled: April 16, 2008Publication date: May 27, 2010Applicant: POLA PHARMA INC.Inventors: Yasushi Murakami, Naoko Kobayashi, Azuma Nishio, Nobuo Kubota
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Publication number: 20100076042Abstract: To provide a pharmaceutical composition which can enhance the storage stability of 1-(1-hydroxymethyl-2,3-dihydroxypropyloxymethyl)-2-nitroimidazole without impairing the effect of the compound. The pharmaceutical composition includes 1-(1-hydroxymethyl-2,3-dihydroxypropyloxymethyl)-2-nitroimidazole, which is represented by formula (1): and a compound having chelating ability.Type: ApplicationFiled: January 17, 2008Publication date: March 25, 2010Applicant: POLA PHARMA INC.Inventors: Yasushi Murakami, Naoko Kobayashi, Azuma Nishio, Nobuo Kubota
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Publication number: 20100004460Abstract: It is an object to provide a method for producing a 2-nitroimidazole derivative having an acyclic sugar chain in a side chain, which is suitable for production of a derivative having a radioisotope. A method for producing 1-(1-benzoyloxymethyl-2-hydroxyethyl)oxymethyl-2-nitroimidazole, characterized by reacting glycerin with a benzoylating agent to obtain 1-O-benzoylglycerin, reacting 1-O-benzoylglycerin with dimethoxymethane in the presence of a dehydrating agent to obtain 4-benzoyloxymethyl-1,3-dioxolane, and then reacting this product with 2-nitroimidazole or 2-nitro-1-trialkylsilylimidazole in the presence of a Lewis acid.Type: ApplicationFiled: January 17, 2008Publication date: January 7, 2010Applicant: POLA PHARMA INCInventor: Azuma Nishio
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Patent number: 5532380Abstract: High purity 2-nitroimidazole derivatives having excellent radiosensitivity and high safety and useful as a drug to be used along with radiotherapy of various cancers can be prepared at a high yield from inexpensive diester of tartaric acid according to the following reaction formua, ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each individually represents an aliphatic group or an aromatic group, and X represents a halogen atom.Type: GrantFiled: July 18, 1994Date of Patent: July 2, 1996Assignee: Pola Chemical Industries, Inc.Inventors: Toshimitsu Suzuki, Azuma Nishio