Abstract: Described herein are methods and computer systems for classification of CD8 T-cell topology using a patient response-based linear cutoff model. A plurality of histology images of tissue samples in a plurality of patients are received by a computer system. An image analysis of the plurality of histology images is performed to obtain a CD8+ T-cell abundance in the tumor parenchyma and stroma in each of the plurality of histology images. Real inflammation scores and tumor infiltration scores are determined based on a polar coordinate transformation of the CD8+ T-cell abundance in the tumor parenchyma and stroma. Based on the real inflammation scores and tumor infiltration scores, a feature space is generated, and linear boundaries or linear cutoffs between a plurality of classifications in the feature space are identified based on the real inflammation scores, the tumor infiltration scores, and patient response data.

Abstract: A VR system for vehicles that may implement methods that address problems with vehicles in motion that may result in motion sickness for passengers. The VR system may provide virtual views that match visual cues with the physical motions that a passenger experiences. The VR system may provide immersive VR experiences by replacing the view of the real world with virtual environments. Active vehicle systems and/or vehicle control systems may be integrated with the VR system to provide physical effects with the virtual experiences. The virtual environments may be altered to accommodate a passenger upon determining that the passenger is prone to or is exhibiting signs of motion sickness.

Abstract: A processor employs a plurality of op cache pipelines to concurrently provide previously decoded operations to a dispatch stage of an instruction pipeline. In response to receiving a first branch prediction at a processor, the processor selects a first op cache pipeline of the plurality of op cache pipelines of the processor based on the first branch prediction, and provides a first set of operations associated with the first branch prediction to the dispatch queue via the selected first op cache pipeline.

Abstract: A product order fulfillment system including a multi-level transport system and a lifting transport system. Each level of the multi-level transport system having a corresponding independent asynchronous level transport system separate and distinct from the asynchronous level transport system corresponding to each other level of the multi-level transport system. Each independent lift axis of the lifting transport system being configured to independently hold at least one case and being communicably coupled to each asynchronous level transport system so as to provide for exchange of the at least one case between each asynchronous level transport system and each independent lift axis. Each independent lift axis is communicably coupled to each other independent lift axis of the more than one lift axis and forms a common output of mixed cases so as to create an ordered sequence of mixed cases in accordance to a predetermined case out ordered sequence.

Abstract: The present invention provides a recombinant oncolytic Herpes Simplex Virus (oHSV) comprising a non-HSV ligand specific for a molecule (protein, lipid, or carbohydrate determinant) present on the surface of a cell (such as a cancer cell) and one or more copies of one or more microRNA target sequences inserted into one or more HSV gene loci, preferably one or more HSV gene(s) required for replication of HSV in normal (i.e., non-cancerous) cells. The invention further provides stocks and pharmaceutical compositions comprising the inventive oHSV and methods for killing tumor cells employing the inventive oHSV.

Abstract: A product order fulfillment system including a multi-level transport system and a lifting transport system. Each level of the multi-level transport system having a corresponding independent asynchronous level transport system separate and distinct from the asynchronous level transport system corresponding to each other level of the multi-level transport system. Each independent lift axis of the lifting transport system being configured to independently hold at least one case and being communicably coupled to each asynchronous level transport system so as to provide for exchange of the at least one case between each asynchronous level transport system and each independent lift axis. Each independent lift axis is communicably coupled to each other independent lift axis of the more than one lift axis and forms a common output of mixed cases so as to create an ordered sequence of mixed cases in accordance to a predetermined case out ordered sequence.

Abstract: A method and/or system that can be implemented on a computing device or tables or board game or otherwise uses a rule set to evaluate data about a situation and actors in order to provide advice regarding strategies for influencing actors and/or other outputs.

Abstract: The presently disclosed subject matter relates to a system and method for customizing a cosmetic product. The system includes: an interface device, in electronic communication with a single batch cosmetic device. A container configured, to be imported into the single batch cosmetic device containing a base. The single batch cosmetic device configured to formulate a customized cosmetic product by mixing a cosmetic additive with the base inside the imported container using at least one mixing element. The container exported from the single batch cosmetic device containing the customized cosmetic.

Abstract: Provided herein are various embodiments relating to antibodies that bind LILRB2. Anti-LILRB2 antibodies can be used in methods to treat disease, for example, cancer.

Abstract: Techniques for performing instruction fetch operations are provided. The techniques include determining instruction addresses for a primary branch prediction path; requesting that a level 0 translation lookaside buffer (“TLB”) caches address translations for the primary branch prediction path; determining either or both of alternate control flow path instruction addresses and lookahead control flow path instruction addresses; and requesting that either the level 0 TLB or an alternative level TLB caches address translations for either or both of the alternate control flow path instruction addresses and the lookahead control flow path instruction addresses.

Abstract: A clamping system for a planetary ball mill includes a base, a clamping lid, including a clamping mechanism configured to secure a grinding container between the base and the clamping mechanism, and a lid configured to pivot with respect to the base from a closed position to an open position, wherein in the open position the grinding container is removable from the clamping system. The system further includes a rotatable arm configured to pivot between a first and second position, wherein in the first position the rotatable arm prevents the clamping lid from rotation to the open position. The clamping system also includes a balancing system having a first counterweight, with a linkage system being coupled between the first counterweight and a carrier plate of the planetary ball mill, the linkage system allowing the first counterweight to move with respect to a rotational axis of the carrier plate.

Abstract: A product order fulfillment system including a multi-level transport system and a lifting transport system. Each level of the multi-level transport system having a corresponding independent asynchronous level transport system separate and distinct from the asynchronous level transport system corresponding to each other level of the multi-level transport system. Each independent lift axis of the lifting transport system being configured to independently hold at least one case and being communicably coupled to each asynchronous level transport system so as to provide for exchange of the at least one case between each asynchronous level transport system and each independent lift axis. Each independent lift axis is communicably coupled to each other independent lift axis of the more than one lift axis and forms a common output of mixed cases so as to create an ordered sequence of mixed cases in accordance to a predetermined case out ordered sequence.

Abstract: A query that is frequently processed to access an object storage is identified. Results from the query returned from the object storage is transformed into a relational database format as a materialized view. When the query is submitted a subsequent time, updated results are managed from the materialized view, other materialized views, and/or the object storage when needed.

Abstract: The presently disclosed subject matter relates to a system and method for customizing a cosmetic product. The system includes: an interface device, in electronic communication with a single batch cosmetic device. A container configured, to be imported into the single batch cosmetic device containing a base. The single batch cosmetic device configured to formulate a customized cosmetic product by mixing a cosmetic additive with the base inside the imported container using at least one mixing element. The container exported from the single batch cosmetic device containing the customized cosmetic.

Abstract: A product order fulfillment system including a multi-level transport system and a lifting transport system. Each level of the multi-level transport system having a corresponding independent asynchronous level transport system separate and distinct from the asynchronous level transport system corresponding to each other level of the multi-level transport system. Each independent lift axis of the lifting transport system being configured to independently hold at least one case and being communicably coupled to each asynchronous level transport system so as to provide for exchange of the at least one case between each asynchronous level transport system and each independent lift axis. Each independent lift axis is communicably coupled to each other independent lift axis of the more than one lift axis and forms a common output of mixed cases so as to create an ordered sequence of mixed cases in accordance to a predetermined case out ordered sequence.

Abstract: In one embodiment, the invention provides an HSV vector comprising a mutant gB and/or a mutant gH glycoprotein, where the viral envelope further comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type. In another embodiment, the invention provides an HSV vector comprising (a) a mutant gC and/or gD envelope glycoprotein which comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type; and (b) a mutant envelope glycoprotein other than gD.

Abstract: Provided herein are various embodiments relating to antibodies that bind LILRB2. Anti-LILRB2 antibodies can be used in methods to treat disease, for example, cancer.

Abstract: Various embodiments herein each include at least one of systems, methods, and software for generating, storing, and using non-unique secondary indexes of semi-structured data in database tables. One method embodiment includes creating and storing a non-unique secondary index (NUSI) for a database table based on column data stored in rows of the database table. The NUSI in some such embodiments identifying an offset to specific data included in the column data of at least some rows of the database table where the specific data is located. Other embodiments include building a NUSI index that includes values embedded therein.

Abstract: A processor employs a plurality of fetch and decode pipelines by dividing an instruction stream into instruction blocks with identified boundaries. The processor includes a branch predictor that generates branch predictions. Each branch prediction corresponds to a branch instruction and includes a prediction that the corresponding branch is to be taken or not taken. In addition, each branch prediction identifies both an end of the current branch prediction window and the start of another branch prediction window. Using these known boundaries, the processor provides different sequential fetch streams to different ones of the plurality of fetch and decode states, which concurrently process the instructions of the different fetch streams, thereby improving overall instruction throughput at the processor.

Abstract: A processor employs a plurality of op cache pipelines to concurrently provide previously decoded operations to a dispatch stage of an instruction pipeline. In response to receiving a first branch prediction at a processor, the processor selects a first op cache pipeline of the plurality of op cache pipelines of the processor based on the first branch prediction, and provides a first set of operations associated with the first branch prediction to the dispatch queue via the selected first op cache pipeline.