Abstract: The present invention relates to novel oxazolidinones (Formula I): or a pharmaceutically acceptable salt having ring A characterized by N-containing monocyclic, bicyclic or spirocyclic substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.

Abstract: A technology is described for automating deployment of a machine learning model. An example method may include receiving, via a graphical user interface, credentials for connecting to a data store containing a plurality of datasets and connecting to the data store using the credentials. A selection of a target metric to predict using the machine learning model can be received, via the graphical user interface, and datasets included in the plurality of datasets that correlate to the target metric can be identified by analyzing the datasets to identify an association between the target metric and data contained within the datasets. The datasets can be input to the machine learning model to train the machine learning model to generate predictions of the target metric, and the machine learning model can be deployed to computing resources in a service provider environment to generate predictions associated with the target metric.

Abstract: In various embodiments method are provided for generating expression cassettes and gene therapy vectors comprising those cassettes that recapitulate the spatiotemporal pattern of expression of the endogenous gene. In certain embodiments the methods comprise (i) selecting a target gene; (ii) identifying putative regulatory elements associated with the target gene; (iii) determining if the regulatory element is a key regulatory element and (iv) providing a list of the key regulatory elements identified in step (iii).

Abstract: Underwater adhesive are provided that include a hydrophobic polymer backbone having periodically embedded dynamic bonding units, where the underwater adhesive has nanophase separation between a first phase of the hydrophobic polymer backbone and a second phase of the dynamic bonding units. The resulting nanophase-separated morphology has clusters of dynamically bonded groups that are protected from water by a surrounding matrix of hydrophobic polymer backbone. This enables a pressure sensitive underwater adhesive with advantages of: no curing needed, reusable, recyclable, and good adhesion strength.

Abstract: A beverage apparatus and system is disclosed. The beverage apparatus is configurable to add flavors, minerals, vitamins, or other such additives to a source fluid, such as purified water, in response to a user's selection of settings, to provide a customized beverage. Advantageously, the beverage apparatus uses the purified water to cleanse the components that come into contact with the additive as part of the preparation of each beverage and includes this cleansing wash as part of the beverage itself, thus providing a self-cleaning apparatus that does not require a separate drain.

Abstract: The battery-powered backpack blower includes a back support assembly including a back plate configured to permit a user to mount the blower to the user's back, and a volute assembly including a first volute portion and a second volute portion. The backpack blower further includes a housing assembly including a battery assembly and a motor assembly therein, the housing assembly is provided intermediate to the back assembly and the volute assembly.

Abstract: A handheld electrosurgical instrument is disclosed, which comprises an upper lobe and a lower lobe, which join at and extend from a narrow neck region substantially perpendicular to one another. The instrument typically includes a surgical tool extending from a distal portion of the upper lobe. The tool may be modular, and the instrument may accommodate any of a plurality of different types and configurations of surgical tools.

Abstract: The battery-powered backpack blower includes a back support assembly including a back plate configured to permit a user to mount the blower to the user's back, and a volute assembly including a first volute portion and a second volute portion. The backpack blower further includes a housing assembly including a battery assembly and a motor assembly therein, the housing assembly is provided intermediate to the back assembly and the volute assembly.

Abstract: Disclosed are pyrazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts and N-oxides thereof, wherein X1, X2, Z1, Z2, the ring system denoted by “a”, R1, A1A, L1B, A1B, L1A, L2, Q, L3, R3, A4A, L4B, A4B, L4A, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein disrupt the eIF4E/eiF4G interaction, and can be used to treat hyperproliferative disorder, a neurological disease or disorder, or autism.

Abstract: Disclosed are compounds useful, for example, in methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formulae and in which R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

Abstract: A beverage apparatus and system is disclosed. The beverage apparatus is configurable to add flavors, minerals, vitamins, or other such additives to a source fluid, such as purified water, in response to a user's selection of settings, to provide a customized beverage. Advantageously, the beverage apparatus uses the purified water to cleanse the components that come into contact with the N additive as part of the preparation of each beverage and includes this cleansing wash as part of the beverage itself, thus providing a self-cleaning apparatus that does not require a separate drain.

Abstract: An ergonomic digital imaging system obviates the need for, and replaces, the standard microscope with binoculars for viewing images, thereby freeing the user from using his or her hands to manipulate images seen through the binoculars of the microscope, whereby the user can use his or her hands for other tasks, such as dental or other surgery, from a position away from the exhaled breath of the patient being treated. The images are maintained focused, no matter how close or far the viewer is to the viewing display screen. The system is collapsible and portable, so that specialists can take the system from office to office, a plug and play work environment. The extended maneuverability of the camera head results in simple and fast patient positioning, and the camera and display module adjust for any comfortable sit or stand ergonomics of the practitioner.

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

Abstract: An ergonomic digital imaging system obviates the need for, and replaces, the standard microscope with binoculars for viewing images, thereby freeing the user from using his or her hands to manipulate images seen through the binoculars of the microscope, whereby the user can use his or her hands for other tasks, such as dental or other surgery, from a position away from the exhaled breath of the patient being treated. The images are maintained focused, no matter how close or far the viewer is to the viewing display screen. The system is collapsible and portable, so that specialists can take the system from office to office, a plug and play work environment. The extended maneuverability of the camera head results in simple and fast patient positioning, and the camera and display module adjust for any comfortable sit or stand ergonomics of the practitioner.

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

Abstract: A device that retains high moisture capacity in the presence of certain contaminants. The device can include a substrate and a desiccant. The device can be configured in relation to an enclosure such that the device absorbs and desorbs moisture from the enclosure.

Abstract: A non-aqueous fabric dyeing method using a non-aqueous dyeing composition is described. The dyeing composition is a fluid at room temperature; contains no more than 5% water, no more than 5% VOCs and no more than 2.5% by weight vinyl monomers. The dye composition includes an organic dye that is solid at temperatures up to 130° C. and which sublimes or boils at 130 to 220° C., and further includes a carrier that is a liquid in the temperature range of 130 to 220° C.

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.