Patents by Inventor B. Daniel Burleigh

B. Daniel Burleigh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8303933
    Abstract: An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regulate in or on the lamellar structure, forming a cooperative ensemble that is capable of binding with enhanced affinity to a complementary affinity site on a target. Each binding compound is bound to the lamellar surface, and may be connected by a linker. The OMMC may contain an effector molecule, such as a diagnostic or therapeutic agent, for administration to a patient who is then diagnosed or treated using the effector molecule.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: November 6, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Gary L. Cantrell, B. Daniel Burleigh
  • Patent number: 8303932
    Abstract: An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regulate in or on the lamellar structure, forming a cooperative ensemble that is capable of binding with enhanced affinity to a complementary affinity site on a target. Each binding compound is bound to the lamellar surface, and may be connected by a linker. The OMMC may contain an effector molecule, such as a diagnostic or therapeutic agent, for administration to a patent who is then diagnosed or treated using the effector molecule.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: November 6, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Gary L. Cantrell, B. Daniel Burleigh
  • Patent number: 8257683
    Abstract: An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regulate in or on the lamellar structure, forming a cooperative ensemble that is capable of binding with enhanced affinity to a complementary affinity site on a target. Each binding compound is bound to the lamellar surface, and may be connected by a linker. The OMMC may contain an effector molecule, such as a diagnostic or therapeutic agent, for administration to a patent who is then diagnosed or treated using the effector molecule.
    Type: Grant
    Filed: October 23, 2009
    Date of Patent: September 4, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Gary L. Cantrell, B. Daniel Burleigh
  • Patent number: 8246930
    Abstract: An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regulate in or on the lamellar structure, forming a cooperative ensemble that is capable of binding with enhanced affinity to a complementary affinity site on a target. Each binding compound is bound to the lamellar surface, and may be connected by a linker. The OMMC may contain an effector molecule, such as a diagnostic or therapeutic agent, for administration to a patent who is then diagnosed or treated using the effector molecule.
    Type: Grant
    Filed: October 23, 2009
    Date of Patent: August 21, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Gary L. Cantrell, B. Daniel Burleigh
  • Publication number: 20100280177
    Abstract: An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regulate in or on the lamellar structure, forming a cooperative ensemble that is capable of binding with enhanced affinity to a complementary affinity site on a target. Each binding compound is bound to the lamellar surface, and may be connected by a linker. The OMMC may contain an effector molecule, such as a diagnostic or therapeutic agent, for administration to a patent who is then diagnosed or treated using the effector molecule.
    Type: Application
    Filed: July 12, 2010
    Publication date: November 4, 2010
    Applicant: MALLINCKRODT INC.
    Inventors: Gary L. Cantrell, B. Daniel Burleigh
  • Publication number: 20100280232
    Abstract: An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regulate in or on the lamellar structure, forming a cooperative ensemble that is capable of binding with enhanced affinity to a complementary affinity site on a target. Each binding compound is bound to the lamellar surface, and may be connected by a linker. The OMMC may contain an effector molecule, such as a diagnostic or therapeutic agent, for administration to a patient who is then diagnosed or treated using the effector molecule.
    Type: Application
    Filed: July 12, 2010
    Publication date: November 4, 2010
    Applicant: MALLINCKRODT INC.
    Inventors: Gary L. Cantrell, B. Daniel Burleigh
  • Patent number: 7713514
    Abstract: An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regulate in or on the lamellar structure, forming a cooperative ensemble that is capable of binding with enhanced affinity to a complementary affinity site on a target. Each binding compound is bound to the lamellar surface, and may be connected by a linker. The OMMC may contain an effector molecule, such as a diagnostic or therapeutic agent, for administration to a patent who is then diagnosed or treated using the effector molecule.
    Type: Grant
    Filed: August 4, 2006
    Date of Patent: May 11, 2010
    Assignee: Mallinckrodt Inc.
    Inventors: Gary L. Cantrell, B. Daniel Burleigh
  • Publication number: 20100041827
    Abstract: An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regulate in or on the lamellar structure, forming a cooperative ensemble that is capable of binding with enhanced affinity to a complementary affinity site on a target. Each binding compound is bound to the lamellar surface, and may be connected by a linker. The OMMC may contain an effector molecule, such as a diagnostic or therapeutic agent, for administration to a patent who is then diagnosed or treated using the effector molecule.
    Type: Application
    Filed: October 23, 2009
    Publication date: February 18, 2010
    Applicant: Mallinckrodt, Inc.
    Inventors: Gary L. Cantrell, B. Daniel Burleigh
  • Publication number: 20100041826
    Abstract: An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regulate in or on the lamellar structure, forming a cooperative ensemble that is capable of binding with enhanced affinity to a complementary affinity site on a target. Each binding compound is bound to the lamellar surface, and may be connected by a linker. The OMMC may contain an effector molecule, such as a diagnostic or therapeutic agent, for administration to a patent who is then diagnosed or treated using the effector molecule.
    Type: Application
    Filed: October 23, 2009
    Publication date: February 18, 2010
    Applicant: MALLINCKRODT INC.
    Inventors: Gary L. Cantrell, B. Daniel Burleigh
  • Patent number: 7087212
    Abstract: An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regulate in or on the lamellar structure, forming a cooperative ensemble that is capable of binding with enhanced affinity to a complementary affinity site on a target. Each binding compound is bound to the lamellar surface, and may be connected by a linker. The OMMC may contain an effector molecule, such as a diagnostic or therapeutic agent, for administration to a patent who is then diagnosed or treated using the effector molecule.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: August 8, 2006
    Assignee: Mallinckrodt, Inc
    Inventors: Gary L. Cantrell, B. Daniel Burleigh
  • Publication number: 20030039683
    Abstract: An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regulate in or on the lamellar structure, forming a cooperative ensemble that is capable of binding with enhanced affinity to a complementary affinity site on a target. Each binding compound is bound to the lamellar surface, and may be connected by a linker. The OMMC may contain an effector molecule, such as a diagnostic or therapeutic agent, for administration to a patent who is then diagnosed or treated using the effector molecule.
    Type: Application
    Filed: August 17, 2001
    Publication date: February 27, 2003
    Applicant: MALLINCKRODT INC.
    Inventors: Gary L. Cantrell, B. Daniel Burleigh
  • Patent number: 5928625
    Abstract: A method of measuring physiological function of a group of body cells, includes the step of selecting a detectable agent capable of emitting a measurable electromagnetic emission. The agent is introduced into body fluid which contacts the group of body cells. The emission is measured, and physiological function is determined based on measurement of the emission.
    Type: Grant
    Filed: March 13, 1997
    Date of Patent: July 27, 1999
    Assignees: Mallinckrodt Inc., Washington University
    Inventors: Richard B. Dorshow, Joseph E. Bugaj, B. Daniel Burleigh, James R. Duncan, Michael Anthony Johnson, William B. Jones