Abstract: Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed, More particularly, an isolated peptide comprising the amino acid sequence LRRFSTAPFAFIDINDVINF, which exhibits anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models is disclosed. The isolate peptide also exhibits anti-lymphangiogenic and directly anti-tumorigenic properties.

Abstract: A method for collaboration using digital notes. A facilitator starts a session during a video conferencing with participants and can share a screen with the participants. The screen displays a code, a session ID, and a link. Participants join the session by scanning the code with a camera, entering the session ID, or accessing the link. During the session, the participants can create digital notes or scan physical notes to have them converted to digital notes. The facilitator then receives the digital notes sent from the participants during the session and moves the digital notes to a group on the facilitator's screen. Since the facilitator's screen is shared with the participants, any participant can view the digital notes in the group from all of the participants for collaboration as controlled by the facilitator.

Abstract: The disclosure is directed toward presses which may comprise planar or curved press plates that can be driven toward and away from each other such as via linear reciprocating movement to press filter media sheets as opposed to using rolls. The press plates can create such features as embossments that may have the ridges and grooves, brands, creases or other such features. The press can create pleated packs or individual panels for non-pleated packs. Additionally, a variety of embossed pleat packs, unique shapes, structural components and other pleat packs that may be formed by presses or other methodology are disclosed as well as filter cartridges using such pleat packs.

Abstract: A saliva-based testing method that bypasses the need for RNA isolation/purification is described herein. In experiments with inactivated SARS-CoV-2 virus spiked into saliva, this method has a limit of detection of 500-1000 viral particles per mL, rivalling the standard NP swab method. Initial studies showed excellent performance with 100 clinical samples. This saliva-based process is operationally simple, utilizes readily available materials, and can be easily implemented by existing testing sites thus allowing for high-throughput, rapid, and repeat testing of large populations.

Abstract: The present disclosure generally relates to displaying information related to a physical activity. In some embodiments, methods and user interfaces for managing the display of information related to a physical activity are described.

Abstract: An eye drop dispenser having a dispensing body configured to be removably secured to a bottle holding a dispensing solution. The dispenser includes a dispensing tip in fluid communication with the bottle for dispensing solution that flows from the bottle out the dispensing tip. The dispenser includes a cheek rest arm that includes a curved portion configured to be positioned adjacent a cheekbone of a user and a cheek rest portion that is positioned along a length of a cheek of the user when the curved portion of the cheek rest arm is positioned adjacent the cheekbone of the user. When the dispensing body is secured to the bottle and the curved portion of the cheek rest arm is positioned adjacent the cheekbone of the user, the dispensing tip is positioned adjacent an eye of the user for dispensing solution into the eye by gravity.

Abstract: A method for manufacturing electrical connector assemblies is disclosed. The electrical connector assemblies include an electrical interposer and a first electrical receptacle. The method includes positioning a fixture coupled to or including an array of the first electrical receptacles such that each of the first electrical receptacles aligns with one of the electrical interposers on an assembly with an array of the electrical interposers. The method further includes reflowing solder to mechanically and electrically couple the array of the first electrical receptacles to the array of the electrical interposers.

Abstract: A frac sand separator system includes a sand separator having an inlet fluidly connected to a well for receiving a fracking return mixture from the well. The sand separator is configured to separate water of the fracking return mixture from particulate matter of the fracking return mixture. The sand separator includes an outlet. The frac sand separator system includes a collection container fluidly connected to the outlet of the sand separator for receiving the particulate matter from the sand separator. At least one outlet valve is fluidly connected between the outlet of the sand separator and the collection container. The frac sand separator system includes a computing device operatively connected to the at least one outlet valve. The computing device includes a processor configured to automatically open the at least one outlet valve such that the particulate matter is released from the sand separator into the collection container.

Abstract: A frac sand separator system includes a sand separator having an inlet fluidly connected to a well for receiving a fracking return mixture from the well. The sand separator is configured to separate water of the fracking return mixture from particulate matter of the fracking return mixture. The sand separator includes an outlet. The frac sand separator system includes a collection container fluidly connected to the outlet of the sand separator for receiving the particulate matter from the sand separator. At least one outlet valve is fluidly connected between the outlet of the sand separator and the collection container. The frac sand separator system includes a computing device operatively connected to the at least one outlet valve. The computing device includes a processor configured to automatically open the at least one outlet valve such that the particulate matter is released from the sand separator into the collection container.

Abstract: An electroporation buffer comprising: a solvent; a sugar; a chloride salt; and a buffering agent. In certain embodiments: the solvent is water; the sugar is glucose or mannitol; the chloride salt is potassium chloride (KCl) or magnesium chloride (MgCl2); and the buffering agent is sodium phosphate, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) and/or dimethyl sulfoxide (DMSO). A method of electroporation, the method comprising applying an electric current to a suspension comprising: isolated eukaryotic cells; a biological material that is exogenous to the cells; and the aforementioned buffer. A recombinant cell produced using such a method. An electroporation apparatus comprising: one or more chambers; one or more pairs of electrodes configured to generate electric fields within the one or more chambers, wherein each electric field corresponds to one chamber; and a flow channel. A method for electroporation comprising utilizing the aforementioned electroporation apparatus.

Abstract: The disclosure is directed toward presses which may comprise planar or curved press plates that can be driven toward and away from each other such as via linear reciprocating movement to press filter media sheets as opposed to using rolls. The press plates can create such features as embossments that may have the ridges and grooves, brands, creases or other such features. The press can create pleated packs or individual panels for non-pleated packs. Additionally, a variety of embossed pleat packs, unique shapes, structural components and other pleat packs that may be formed by presses or other methodology are disclosed as well as filter cartridges using such pleat packs.

Abstract: The present disclosure is directed toward assembly of pleat packs using a welder and an anvil that can push adjacent pleat panels together along a crease. Other aspects are directed to welding pocket pleats and welded pocket pleats formed thereby that are suitable for filter fluid and ultrasonically cutting and sealing seams into filter media using a welding assembly such as an ultrasonic sonotrode and an anvil.

Abstract: The disclosure is directed toward presses which may comprise planar or curved press plates that can be driven toward and away from each other such as via linear reciprocating movement to press filter media sheets as opposed to using rolls. The press plates can create such features as embossments that may have the ridges and grooves, brands, creases or other such features. The press can create pleated packs or individual panels for non-pleated packs. Additionally, a variety of embossed pleat packs, unique shapes, structural components and other pleat packs that may be formed by presses or other methodology are disclosed as well as filter cartridges using such pleat packs.

Abstract: A method for manufacturing electrical connector assemblies is disclosed. The electrical connector assemblies include an electrical interposer and a first electrical receptacle. The method includes positioning a fixture coupled to or including an array of the first electrical receptacles such that each of the first electrical receptacles aligns with one of the electrical interposers on an assembly with an array of the electrical interposers. The method further includes reflowing solder to mechanically and electrically couple the array of the first electrical receptacles to the array of the electrical interposers.

Abstract: Filter systems, filters, and methods of managing filter systems are provided. The filter systems utilize large filters that are too large to be manually handled by service personnel. As such, the filter systems and methods utilize filter positioning units for handling the filters during maintenance intervals. Some systems include sensor for remotely monitoring the status of the filters and the information can be used to reverse pulse the filters as well as to indicate the end of the service life of the filters. The filters can be refurbished with new filter media.

Abstract: A frac sand separator system includes a sand separator having an inlet fluidly connected to a well for receiving a fracking return mixture from the well. The sand separator is configured to separate water of the fracking return mixture from particulate matter of the fracking return mixture. The sand separator includes an outlet. The frac sand separator system includes a collection container fluidly connected to the outlet of the sand separator for receiving the particulate matter from the sand separator. At least one outlet valve is fluidly connected between the outlet of the sand separator and the collection container. The frac sand separator system includes a computing device operatively connected to the at least one outlet valve. The computing device includes a processor configured to automatically open the at least one outlet valve such that the particulate matter is released from the sand separator into the collection container.

Abstract: Electroporation is a technique in which an electrical field is applied to cells in order to increase the permeability of the cell membrane. This allows for chemicals, drugs, and/or macromolecules such as proteins and nucleic acids to be introduced into the cells. Embodiments relate to an electroporation apparatus. The electroporation apparatus comprises: a plurality of chambers configured to store a plurality of cells during an electroporation process; a plurality of electrodes configured to generate a plurality of electric fields within the plurality of chambers during the electroporation process, each electric field of the plurality of electric fields corresponding to one chamber of the plurality of chambers; a flow channel configured to transport the plurality cells during a cell collection process after the electroporation process; and a plurality of valves connecting the plurality of chambers to the flow channel.

Abstract: According to one aspect, a system is adapted to actively control one or more operating parameters associated with: a wellbore extending in a subterranean formation, and/or wellbore fluid flowing out of the wellbore via a wellhead. The system includes one or more sensors; an electronic controller adapted to receive from the one or more sensors measurement data; and a valve through which the wellbore fluid is adapted to flow. The valve is adapted to be in communication with the electronic controller. The active control of the at least one of the one or more operating parameters is adapted to facilitate: maintenance of the integrity of the wellbore, and/or enhancement of oil and/or gas production out of the wellbore. In one embodiment, the wellbore fluid flow is frac flow-back. In another aspect, a system is adapted to monitor vent gas separated from wellbore fluid flowing out a wellhead.

Abstract: The presently disclosed subject matter provides fragrance compositions and fragrance combinations that can stimulate the trigeminal system. The compositions and combinations of the presently disclosed subject matter can include both one or more trigeminal-stimulating compounds and one or more additional fragrance compounds. The trigeminal-stimulating compounds can include cooling, warming, and tingling compounds.

Abstract: A filter element and/or filter assembly such as for engine air filtration is provided that may include a filter housing, a pre-cleaner or cover, a primary filter element and optionally a secondary filter element. Different components may share a common seal to seal against unfiltered airflow. For example the secondary filter and the primary filter may use the same seal that may be carried by the primary filter. The secondary filter may also surround the primary filter.