Abstract: A physiologic signal transmission system for an individual includes a physiologic signal transmitter and receiver device. The physiologic transmitter device includes a first receiver configured to obtain sensor signals monitoring physiologic states of the individual; a first processor configured to determine stimulation signals based on the obtained sensor signals, where the stimulation signals encode instructions to modulate functions of a target organ of the individual; and a stimulation device configured to apply the determined stimulation signals to a physiologic system or structure of the individual.

Abstract: The present invention relates to a system for communicating an operational state of a neuronal stimulation apparatus to an individual, comprising: means for determining the operational state of the apparatus; means for transmitting a first neuronal stimulation signal to a neuronal stimulation means of the individual adapted to elicit a sensory percept in the cortex of the individual, wherein the first neuronal stimulation signal is indicative of the operational state of the apparatus. The present invention further relates to a method and computer program comprising the steps of: determining the operational state of the apparatus, transmitting a neuronal stimulation signal to a neuronal stimulation means of the individual adapted to elicit a sensory percept in the cortex of the individual, wherein the first neuronal stimulation signal is indicative of the determined operational state of the apparatus.

Abstract: During a sEEG (stereo-electroencephalography) intervention into the skull of a patient, there is requirement to drill a large number of trajectories. Typically, instrument stabilisation platforms and robots for protocols requiring only one or two trajectories are rigidly fixed to the skull using surgical anchor members fixed into the skull around the one or two trajectories. However, because sEEG interventions require a large number of trajectories, an impractical number of surgical anchor members need to be fixed into the skull resulting in patient discomfort. Attachment of an intervention platform to all surgical anchor members is not required at once. Accordingly, it is proposed to search for intersection points of the maximum extent of an intervention platform between at least two trajectory entry points on an object of interest of patient, so that at least one surgical anchor member can be shared when the intersection point is at first and the second trajectories.

Abstract: A computer-assisted and automatic identification of possible cranial positions for any kind of implant is presented. In this method, skull data of the individual patient's skull are used as well as statistical skull data which include so-called skull avoidance zones. Further, a digital template of the implant is used to find these possible positions. The implant may be e.g. an IPG and/or the screws of a fixation frame, but these are only embodiments of implants and other implants may be used with the present invention as well. The computer-implemented medical method of the present invention removes the uncertainty whether a given patient can safely receive an implant, like for example a cranial IPG, which was previously only possible on the basis of human judgement. Furthermore, the present invention removes the uncertainty whether a given patient can be safely fixated in a stereotactic frame or a Mayfield head clamp.

Abstract: A method is provided for supporting determination of medical procedure by created adapted population data. The adapted population is determined by a user entered degree of similarity of the patient and is used to describe an adapted probability that the anatomical structure can be treated. The method further utilizes at least analysis of the medical image data from the patient. The created adapted population data describes an adapted population based on the user entered similarity and generates adapted outcome atlas data describing an adapted probability that a specific anatomical structure can be treated successfully by the medical procedure. The adapted probability is determined based on the generated adapted population.

Abstract: Disclosed is a computer-implemented method of determining a consensus plane for imaging an elongate medical device such as an electrode or a catheter. When positioning an analytical device such that its imaging plane is parallel to or coincides with the consensus plane, an optimal image of the elongate medical device can be generated. The consensus plane is determined by analyzing patient image data used for planning an imaging procedure, planned trajectory data defining a planned position of the elongate medical device relative to the position of an anatomical body part, imaging device constraint data describing machine constraints governing operation of the medical imaging device, avoidance region position data defining the position of anatomical regions of the patient's body, and orientation condition data defining a boundary condition for an angle between the orientation of the consensus plane and the orientation of the characteristic geometric quantity of the elongate medical device.

Abstract: A method is provided for determining an orientation of nerve fibres relative to a non-physiological electric field. Patient medical image data is acquired, which describes a patient medical image of an anatomical body part of a patient's body. The anatomical body part includes nerve tissue comprising white matter nerve fibres. Diffusion image data is acquired, which describes a diffusion-enhanced image of the anatomical body part. Atlas data is acquired, which describes a spatial distribution of grey value-based tissue classes in a model body part representing a model of the anatomical body part. Based on the patient image data, the diffusion image data, and the atlas data, fibre orientation data is determined. The fibre orientation data describes an orientation of the white matter nerve fibres. Electric field orientation data is acquired, which describes an orientation of the non-physiological electric field.

Abstract: Disclosed is a computer-implemented medical data processing method for planning a position of an electric stimulation device for neurostimulation of at least two target regions (TV1, . . . , TVN) disposed in an anatomical body part of a patient's body, the electric stimulation device (7) comprising at least two electric contacts, the method comprising executing, on at least one processor of at least one computer (3), steps of: a) acquiring (S1.1), at the at least one processor, medical image data describing a digital image of the anatomical body part, wherein the anatomical body part contains at least two target regions (TV1, . . . , TVN); b) determining (S1.2), by the at least one processor and based on the medical image data, target position data describing a position of each target region (TV1, . . . , TVN) in the anatomical body part; c) acquiring (S1.

Abstract: During a sEEG (stereo-electroencephalography) intervention into the skull of a patient, there is requirement to drill a large number of trajectories. Typically, instrument stabilisation platforms and robots for protocols requiring only one or two trajectories are rigidly fixed to the skull using surgical anchor members fixed into the skull around the one or two trajectories. However, because sEEG interventions require a large number of trajectories, an impractical number of surgical anchor members need to be fixed into the skull resulting in patient discomfort. Attachment of an intervention platform to all surgical anchor members is not required at once. Accordingly, it is proposed to search for intersection points of the maximum extent of an intervention platform between at least two trajectory entry points on an object of interest of patient, so that at least one surgical anchor member can be shared when the intersection point is at first and the second trajectories.

Abstract: The present invention relates to a system for communicating an operational state of a neuronal stimulation apparatus to an individual, comprising: means for determining the operational state of the apparatus; means for transmitting a first neuronal stimulation signal to a neuronal stimulation means of the individual adapted to elicit a sensory percept in the cortex of the individual, wherein the first neuronal stimulation signal is indicative of the operational state of the apparatus. The present invention further relates to a method and computer program comprising the steps of: determining the operational state of the apparatus, transmitting a neuronal stimulation signal to a neuronal stimulation means of the individual adapted to elicit a sensory percept in the cortex of the individual, wherein the first neuronal stimulation signal is indicative of the determined operational state of the apparatus.

Abstract: The present invention relates to a system for stimulating the sensory cortex of an individual, comprising: means for obtaining a neuronal stimulation signal adapted to provide a movement cue for the individual and means for transmitting the neuronal stimulation signal to an electric contact of a neuronal stimulation electrode that is already implanted into the brain of the individual for a purpose different from providing the movement cue.

Abstract: The present invention relates to a medical data processing method of determining an outcome quality of a medical procedure, the method comprising the following steps which are constituted to be executed by a computer: a) acquiring (S1) pre-completion medical image data describing an anatomical structure of a patient's body in a state before the medical procedure has been completed on the anatomical structure, the anatomical structure being subject to the medical procedure; b) acquiring (S1) pre-completion non-image medical data describing a state and medical history of the patient before the medical procedure has been completed on the anatomical structure; c) acquiring (S2) medical procedure planning data describing a plan for execution of the medical procedure to be carried out on the anatomical structure; d) determining (S2), based on the pre-completion medical image data and the medical procedure planning data, procedure application describing an application of the medical procedure planning data to the pr

Abstract: The invention relates to a computer-implemented medical data processing method for determining a heartbeat signal describing the heartbeat of a patient in the time domain, the method comprising executing, on a processor of a computer, steps of: a) acquiring, at the processor, acceleration measurement data describing an acceleration in the time domain of an anatomical body part measured on an external surface of the anatomical body part; b) determining, by the processor, component analysis data describing a result of an independent component analysis in the time domain of the acceleration measurement data; c) acquiring, at the processor, heartbeat template data describing template shapes of heartbeat in the time domain; d) determining, by the processor and based on the component analysis data and the heartbeat template data, recurrent shape data describing a recurrence of certain signal shapes in the component analysis data; e) determining, based on the recurrent shape data, heartbeat signal data describing a

Abstract: The present invention relates to a system for providing neuronal stimulation signals configured to elicit sensory percepts in the cortex of an individual, comprising means for obtaining spatial information relating to the actual or planned position of at least one neuronal stimulation means relative to at least one afferent axon targeting at least one sensory neuron in the cortex of the individual and means for determining at least one neuronal stimulation signal to be applied to at least one afferent axon via the at least one neuronal stimulation means based at least in part on the obtained spatial information.

Abstract: A system is disclosed for determining a coverage of a target anatomical structure by an electric stimulation field. The system includes a computer to acquire patient image data and the atlas data, determine, based on the patient image data and the atlas data, target structure position data describing a position of the target anatomical structure in the medical image of the anatomical body part of the patient. The system also acquires electrode position data and stimulation field data describing an electric stimulation field around the position of the electrode. The system also includes an electrode configuring device for adjusting an emission configuration of the electrode.

Abstract: Disclosed is a computer-implemented method for determining a coverage of a target anatomical structure by an electric stimulation field, the method comprising executing, on at least one processor of at least one computer, steps of: a) acquiring patient image data describing a medical image of the anatomical body part of a patient, wherein the anatomical body part includes the target anatomical structure b) acquiring atlas data describing a model of the anatomical body part and information about the position of a model target structure in the model of the anatomical body part, the model target structure corresponding to the target anatomical structure; c) determining, based on the patient image data and the atlas data, target structure position data describing a position of the target anatomical structure in the medical image of the anatomical body part of the patient; d) acquiring, electrode position data describing a relative position between a position of an electrode and a position of the anatomical bod

Abstract: Disclosed is a computer-implemented medical data processing method for determining a stimulated nerve fibre disposed in an anatomical body part of a patient's body, the method comprising executing, on at least one processor of at least one computer, steps of: a) acquiring, at the at least one processor, medical image data describing a digital image of the anatomical body part, wherein the anatomical body part contains at least one nerve fibre extending in a direction between an internal part of the anatomical body part and a substantially exterior part of the anatomical body part; b) acquiring, at the at least one processor, atlas data describing an image-based model of the anatomical body part including a representation of the at least one nerve fibre; c) determining, by the at least one processor and based on the medical image data and the atlas data, exterior part data describing an association between the exterior part and the nerve fibre; d) acquiring, at the at least one processor, stimulation signal da

Abstract: The present disclosure sets forth a guiding tube for placing medical implants within body tissue. The guiding tube includes an elongated, dimensionally stable tubular body encompassing an inner channel adapted to receive a medical implant wherein the tubular body has at least one electromagnetic element, the element configured to exert an electromagnetic force on at least one magnetic element of the medical implant inserted into the inner channel of the guiding tube. The medical implant includes a stimulation lead having at least one directional electrode with an elongated body insertable into an inner channel enclosed by a tubular body of the guiding tube.

Abstract: Disclosed is a computer-implemented medical data processing method for planning a position of an electric stimulation device for neurostimulation of at least two target regions (TV1, . . . , TVN) disposed in an anatomical body part of a patient's body, the electric stimulation device (7) comprising at least two electric contacts, the method comprising executing, on at least one processor of at least one computer (3), steps of: a) acquiring (S1.1), at the at least one processor, medical image data describing a digital image of the anatomical body part, wherein the anatomical body part contains at least two target regions (TV1, . . . , TVN); b) determining (S1.2), by the at least one processor and based on the medical image data, target position data describing a position of each target region (TV1, . . . , TVN) in the anatomical body part; c) acquiring (S1.

Abstract: The present invention relates to positioning a patient's body part including a target relative to an imaging device that generates a radiation beam directed towards the target. Geometry data is received that describes the geometry of at least one structure located in the field of view of the imaging device. Tracking date is received that describes the spatial location and/or orientation of the at least one structure within the field of view of the imaging device. Position data is determined that incorporates the geometry date and the tracking data. The position data describes whether the location and/or orientation of the at least one structure with respect to an image trajectory is desirable. Repositioning data is determined that describes a desired location and/or orientation of the at least one structure with respect to the image trajectory. The repositioning data is output to allow repositioning of the at least one structure.