Patents by Inventor B. Lynn Allen-Hoffmann

B. Lynn Allen-Hoffmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED SKIN CONSTRUCT OVERLAY OF AUTOGRAFT
    Publication number: 20230330153
    Abstract: The present disclosure provides methods for treating wounds by applying a meshed autograft and skin substitute overlay wherein the skin substitute is an organotypic human skin equivalent comprising NIKS® cells.
    Type: Application
    Filed: July 8, 2021
    Publication date: October 19, 2023
    Inventors: ALLEN R. COMER, JANICE SMIELL, B. LYNN ALLEN-HOFFMANN, MARY LOKUTA, RANDI RUTAN
  • METHODS FOR TREATING ACUTE WOUNDS AND IMPROVING OUTCOMES
    Publication number: 20220347353
    Abstract: The present disclosure provides methods for treating acute wounds and improving outcomes by applying to an acute wound a skin substitute that is an organotypic human skin equivalent comprising NIKS cells. In certain embodiments, the closed wound has improved vascularity, improved pigmentation, decreased thickness, decreased pain, increased pliability, increased surface area, decreased stiffness, decreased itching, improved color, or any combination thereof, as assessed by an observer or by the subject, as compared to an autograft or another skin substitute.
    Type: Application
    Filed: September 28, 2020
    Publication date: November 3, 2022
    Inventors: Janice Smiell, Allen Comer, Mary Lokuta, B. Lynn Allen-Hoffmann
  • CRYOPRESERVATION OF VIABLE HUMAN SKIN SUBSTITUTES
    Publication number: 20220192181
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for cryopreserving viable skin substitutes.
    Type: Application
    Filed: March 14, 2022
    Publication date: June 23, 2022
    Inventors: B. Lynn Allen-Hoffmann, John C. Pirnstill, Kenneth R. Gratz, Allen R. Comer
  • Cryopreservation of viable human skin substitutes
    Patent number: 11297829
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for cryopreserving viable skin substitutes.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: April 12, 2022
    Assignee: Stratatech Corporation
    Inventors: B. Lynn Allen-Hoffmann, John C. Pirnstill, Kenneth R. Gratz, Allen R. Comer
  • VIABLE BIOENGINEERED SKIN CONSTRUCTS
    Publication number: 20210355451
    Abstract: The present disclosure is directed to viable bioengineered skin constructs.
    Type: Application
    Filed: May 13, 2021
    Publication date: November 18, 2021
    Inventors: B. Lynn Allen-Hoffmann, Allen R. Comer, Kenneth R. Gratz, Barry M. Steiglitz
  • HUMAN SKIN EQUIVALENTS EXPRESSING EXOGENOUS POLYPEPTIDES
    Publication number: 20210146012
    Abstract: The present invention relates generally to compositions for wound closure. More specifically, the present invention provides human skin equivalents engineered to express exogenous polypeptides (e.g., antimicrobial polypeptides and keratinocyte growth factor 2) and compositions and methods for making human skin equivalents engineered to express exogenous polypeptides. In addition, the present invention provides methods for treatment of wounds with human skin equivalents engineered to express exogenous polypeptides.
    Type: Application
    Filed: January 5, 2021
    Publication date: May 20, 2021
    Inventors: John M. Centanni, B. Lynn Allen-Hoffmann
  • Cold storage of organotypically cultured skin equivalents for clinical applications
    Patent number: 10743533
    Abstract: The present invention relates generally to systems and methods for storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: August 18, 2020
    Assignee: Stratatech Corporation
    Inventors: B. Lynn Allen-Hoffmann, John Pirnstill
  • HUMAN SKIN SUBSTITUTES EXPRESSING IL-12
    Publication number: 20190030130
    Abstract: The present invention relates generally to compositions for treating patients that have skin cancer or have recently had skin cancers removed. More specifically, the present invention provides human skin substitutes engineered to express exogenous IL-12 and compositions and methods for making human skin substitutes engineered to express exogenous IL-12. In addition, the present invention provides methods for treatment of sites on a patient where skin cancers have been removed with human skin substitutes engineered to express exogenous IL-12.
    Type: Application
    Filed: October 2, 2018
    Publication date: January 31, 2019
    Inventors: Allen R. Comer, B. Lynn Allen-Hoffmann
  • CRYOPRESERVATION OF VIABLE HUMAN SKIN SUBSTITUTES
    Publication number: 20190000071
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for cryopreserving viable skin substitutes.
    Type: Application
    Filed: September 5, 2018
    Publication date: January 3, 2019
    Inventors: B. Lynn Allen-Hoffmann, John C. Pirnstill, Kenneth R. Gratz, Allen R. Comer
  • Cryopreservation of viable human skin substitutes
    Patent number: 10091983
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for cryopreserving viable skin substitutes.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 9, 2018
    Assignee: Stratatech Corporation
    Inventors: B. Lynn Allen-Hoffmann, John C. Pirnstill, Kenneth R. Gratz, Allen R. Comer
  • Dried and irradiated skin equivalents for ready use
    Patent number: 9867904
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: January 16, 2018
    Assignee: Stratatech Corporation
    Inventors: Allen R. Comer, B. Lynn Allen-Hoffmann, Barry Steiglitz
  • COLD STORAGE OF ORGANOTYPICALLY CULTURED SKIN EQUIVALENTS FOR CLINICAL APPLICATIONS
    Publication number: 20170339943
    Abstract: The present invention relates generally to systems and methods for storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
    Type: Application
    Filed: December 12, 2016
    Publication date: November 30, 2017
    Inventors: B. Lynn Allen-Hoffmann, John Pirnstill
  • DRIED AND IRRADIATED SKIN EQUIVALENTS FOR READY USE
    Publication number: 20170087276
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
    Type: Application
    Filed: December 13, 2016
    Publication date: March 30, 2017
    Inventors: Allen R. Comer, B. Lynn Allen-Hoffmann, Barry Steiglitz
  • Dried and irradiated skin equivalents for ready use
    Patent number: 9526811
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: December 27, 2016
    Assignee: STRATATECH CORPORATION
    Inventors: Allen R. Comer, B. Lynn Allen-Hoffmann, Barry Steiglitz
  • Human skin equivalents expressing exogenous polypeptides
    Patent number: 9526748
    Abstract: The present invention relates generally to compositions for wound closure. More specifically, the present invention provides human skin equivalents engineered to express exogenous polypeptides (e.g., antimicrobial polypeptides and keratinocyte growth factor 2) and compositions and methods for making human skin equivalents engineered to express exogenous polypeptides. In addition, the present invention provides methods for treatment of wounds with human skin equivalents engineered to express exogenous polypeptides.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: December 27, 2016
    Assignee: STRATATECH CORPORATION
    Inventors: John M. Centanni, B. Lynn Allen-Hoffmann
  • Skin substitutes with improved purity
    Patent number: 9295543
    Abstract: The present invention relates to in vitro cultured skin substitutes. In particular, the present invention relates to compositions and methods for the development of cultured skin substitutes using NIKS cells.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: March 29, 2016
    Assignee: STRATATECH CORPORATION
    Inventors: B. Lynn Allen-Hoffmann, Cathy Ann-Rasmussen Ivarie, John M. Centanni
  • Human skin equivalents expressing exogenous polypeptides
    Patent number: 9163076
    Abstract: The present invention relates generally to compositions for wound healing. More specifically, the present invention provides human skin equivalents engineered to express exogenous proteinase inhibitor polypeptides (e.g., TIMP-1 polypeptides) and compositions and methods for making human skin equivalents engineered to express exogenous polypeptides. In addition, the present invention provides methods for treatment of wounds with human skin equivalents engineered to express exogenous polypeptides.
    Type: Grant
    Filed: March 1, 2006
    Date of Patent: October 20, 2015
    Assignee: Stratatech Corporation
    Inventors: B. Lynn Allen-Hoffmann, Cathy Ann-Rasmussen Ivarie, Christina L. Thomas-Virnig
  • DRIED AND IRRADIATED SKIN EQUIVALENTS FOR READY USE
    Publication number: 20150196686
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
    Type: Application
    Filed: March 26, 2015
    Publication date: July 16, 2015
    Inventors: Allen R. Comer, B. Lynn Allen-Hoffmann, Barry Steiglitz
  • Dried and irradiated skin equivalents for ready use
    Patent number: 8992997
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: March 31, 2015
    Assignee: Stratatech Corporation
    Inventors: Allen R. Comer, B. Lynn Allen-Hoffmann, Barry Steiglitz
  • HUMAN SKIN EQUIVALENTS EXPRESSING EXOGENOUS POLYPEPTIDES
    Publication number: 20140335064
    Abstract: The present invention relates generally to compositions for wound closure. More specifically, the present invention provides human skin equivalents engineered to express exogenous polypeptides (e.g., antimicrobial polypeptides and keratinocyte growth factor 2) and compositions and methods for making human skin equivalents engineered to express exogenous polypeptides. In addition, the present invention provides methods for treatment of wounds with human skin equivalents engineered to express exogenous polypeptides.
    Type: Application
    Filed: July 18, 2014
    Publication date: November 13, 2014
    Inventors: John M. Centanni, B. Lynn Allen-Hoffmann