Abstract: The present application relates to the use of 3,3?-(1,3-phenylenebis(oxy))bis(1-(piperidin-1-yl)propan-2-ol (VE607) or a pharmaceutically acceptable salt thereof for the inhibition of SARS-CoV-2 and/or management of COVID-19.

Abstract: An ostomy leakage detection system includes a sensing accessory, a wearable subsystem, a charging dock, and a mobile application. The sensing accessory includes a sensor region comprising a plurality of sensors for measuring resistance of an ostomy appliance, a connector region for connecting to the wearable subsystem, and a tail region extending between the sensor region and the connector region.

Abstract: A medicine administration and tracking system includes a delivery device configured to deliver a plurality of doses of medicine over a plurality of days and a computing device configured to receive dose information for each dose. The computing device includes a software application operable to cause the computing device to retrieve the dose information for all doses within a pre-determined period of days, categorize each dose within the pre-determined period of days into one of a plurality of time blocks throughout a 24-hour timeframe, determine a time of interest based on a time block of the plurality of time blocks having the least amount of doses categorized therein, and select a physiological parameter reading from a plurality of physiological parameter readings as a physiological parameter reading of interest based on a proximity of a time of the physiological parameter reading to the determined time of interest.

Abstract: Compounds and methods of treating HIV-1 in a human infected with HIV-1 or preventing HIV-1 infection in a human susceptible to infection with HIV-1 are provided. The compounds are of formula (I), (II), and (IA), wherein R1-R7, X, X?, Y, Y?, Z, and n are defined herein, and the methods comprises administering therapeutically effective amounts of these compounds to the human.

Abstract: Systems, apparatuses, and methods of an event-based automatic transaction on behalf of a user include and not limited to, determining, based on a plurality of information sources including a plurality of news information sources independent of a particular physical location, a probability of an event occurring, the probability being based on a predetermined percentage of news information sources indicating that the event is going to occur or is occurring, in response to the probability of the event occurring satisfying a predetermined threshold corresponding to the predetermined percentage, determining a location impacted by the event, in response to determining that the location of the user is proximate to the location impacted by the event, initiating a transaction with a mobile banking client application linked to an authorized financial account on behalf of the user, the authorized financial account being associated with the user and provided by the financial institution computing system.

Abstract: A system may include a first controller and a second controller communicatively coupled to the first controller via a bidirectional communication channel and configured to drive a load in accordance with a target current signal, sample a load voltage of the load at a sample rate substantially slower than a time duration of electrical transients of the load, calculate a resistance of the load based on a current signal and the load voltage and communicate information indicative of the resistance to the first controller at a time interval substantially slower than the time duration of electrical transients of the load, detect when one or more accuracy-reducing events associated with the system occur, wherein an accuracy-reducing event is one which negatively affects accuracy of calculation of the resistance, and modify the information provided to the first controller when one or more accuracy-reducing events occur.

Abstract: Systems, methods, and other embodiments associated with selection of supply locations from among multiple candidate locations in order to maximize fulfillment of orders that include multiple item types when there is a shortage of one or more of the item types are described. In one embodiment, a method includes accessing a plurality of orders that include multiple types of items and a plurality of candidate locations for fulfilling the orders. Candidate locations are then selected to fulfill individual orders based on finding the one of the candidate locations that has a lowest value for a flexibility metric. A user interface is generated to display the assignments. In response to a request to finalize the assignments, allocation instructions are generated to allocate the multiple types of items to the orders in accordance with the finalized instructions.

Abstract: High speed waveguide-based data communication systems are disclosed. Such systems may include separable electrical connectors, forming signal propagation paths between electronic assemblies with one or more waveguides.

Abstract: This document provides methods and materials related to treating a disease. For example, this document provides methods for treating a subject's disease based on identifying the risk of progressive multifocal leukoencephalopathy PML using a genetic test.

Abstract: A Stirling cycle machine with a liquid fuel/gaseous fuel burner. The burner may include a preheater to capture the thermal energy of the exhaust. The burner directs the preheated air to each burner head, where it enters a prechamber. Each burner head includes a fuel nozzle that directs liquid or gaseous fuel into the prechamber. The prechamber is fluidically connected to a combustion chamber via a prechamber nozzle that has a smaller opening than the prechamber. The burner head ignites the fuel air mixture in the prechamber with an ignitor located above or within the prechamber. The flame is initially lit as a diffusion flame in the prechamber. The flame is pushed out of the prechamber into the combustion chamber by an increased air flow rate. The liquid fuel from the nozzle now evaporates in the prechamber and forms a prevaporized flame in the combustion chamber.

Abstract: This document provides methods and materials related to treating a disease. For example, this document provides methods for treating a subject's disease based on identifying the risk of progressive multifocal leukoencephalopathy PML using a genetic test.

Abstract: This document provides methods and materials related to treating a disease. For example, this document provides methods for treating a subject's disease based on identifying the risk of progressive multifocal leukoencephalopathy PML using a genetic test.

Abstract: An ultrasonic instrument includes a body, an actuation assembly, a shaft assembly, and an end effector. The actuation assembly includes an activation member that is operable to move in a first direction to select a mode of operation. The shaft assembly extends distally from the body and includes an acoustic waveguide. The end effector includes an ultrasonic blade that is in acoustic communication with the acoustic waveguide. The activation member is operable to move in a second direction to activate the end effector in a mode of operation selected by movement of the activation member in the first direction.

Abstract: A system for performing shear-assisted extrusion can include a front fixed endstock and a rear fixed endstock. The system can include a front movable headstock and a rear movable headstock. The system can include a die tool connected to the front fixed endstock. The die tool can include a face configured to engage and plasticize a face of feedstock material. The die tool can define an opening to receive plasticized feedstock material therethrough. The system can include a front spindle supported by the front movable headstock. The front spindle can be rotatable to rotate the feedstock material with respect to the front movable headstock. The system can include a rear spindle connected to the rear movable headstock, the rear spindle rotatable with respect to the rear movable headstock and the die tool.

Abstract: Systems and methods for measuring a temperature at a location within a patient's body such as at an in vivo location proximate to a site of intravenous fluid administration, are disclosed. In some embodiments, an insertable device includes an insertion tube member having a tip configured to be inserted into a blood vessel (or other body lumen) of a patient, and a temperature sensor operatively coupled to the insertion tube proximate the tip and configured to measure a temperature within the blood vessel during administration of a fluid through the insertion tube. The device may also include a controller operable to receive one or more signals from the temperature sensor indicative of the temperature within the blood vessel proximate the tip of the insertion tube.

Abstract: Clamp assemblies and associated methods are disclosed. According to one aspect, a clamp assembly may comprise a shell, a tensioning mechanism, and a retainer. The shell includes a pair of segments sized to be positioned over a joint connection, with the pair of segments being moveable between an open position and a contracted position. The tensioning mechanism is operable to tighten the pair of segments and includes a threaded shaft extending through a segment opening defined in a first segment of the pair of segments. The retainer is coupled with the first segment and includes a first cantilevered flange configured to engage the threaded shaft to retain the threaded shaft in the segment opening when the shell is in the open position.

Abstract: A medicine administration and tracking system includes a delivery device configured to deliver a plurality of doses of medicine over a plurality of days and a computing device configured to receive dose information for each dose. The computing device includes a software application operable to cause the computing device to retrieve the dose information for all doses within a pre-determined period of days, categorize each dose within the pre-determined period of days into one of a plurality of time blocks throughout a 24-hour timeframe, determine a time of interest based on a time block of the plurality of time blocks having the least amount of doses categorized therein, and select a physiological parameter reading from a plurality of physiological parameter readings as a physiological parameter reading of interest based on a proximity of a time of the physiological parameter reading to the determined time of interest.