Patents by Inventor Babak Banapour

Babak Banapour has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
    Patent number: 7094599
    Abstract: Disclosed is a method of directing a cellular immune response against an HIV-infected cell in a mammal involving administering to the mammal an effective amount of therapeutic cells which express a membrane-bound, proteinaceous chimeric receptor comprising (a) an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection and (b) an intracellular portion which is capable of signalling the therapeutic cell to destroy the receptor-bound HIV-infected cell. Also disclosed are cells which express the chimeric receptors and DNA and vectors encoding the chimeric receptors.
    Type: Grant
    Filed: August 24, 2001
    Date of Patent: August 22, 2006
    Assignee: The General Hospital Corporation
    Inventors: Brian Seed, Babak Banapour, Charles Romeo, Waldemar Kolanus
  • Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
    Patent number: 6753162
    Abstract: Disclosed is a method of directing a cellular immune response against an HIV-infected cell in a mammal involving administering to the mammal an effective amount of therapeutic cells which express a membrane-bound, proteinaceous chimeric receptor comprising (a) an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection and (b) an intracellular portion which is capable of signalling the therapeutic cell to destroy the receptor-bound HIV-infected cell. Also disclosed is a second method of treating HIV in a mammal involving administering to the mammal an effective amount of therapeutic cells expressing a membrane-bound, proteinaceous chimeric receptor comprising an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection.
    Type: Grant
    Filed: February 24, 1995
    Date of Patent: June 22, 2004
    Assignee: The General Hospital Corporation
    Inventors: Brian Seed, Babak Banapour, Charles Romeo, Waldemar Kolanus
  • Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
    Publication number: 20030138410
    Abstract: Disclosed is a method of directing a cellular immune response against an HIV-infected cell in a mammal involving administering to the mammal an effective amount of therapeutic cells which express a membrane-bound, proteinaceous chimeric receptor comprising (a) an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection and (b) an intracellular portion which is capable of signalling the therapeutic cell to destroy the receptor-bound HIV-infected cell. Also disclosed are cells which express the chimeric receptors and DNA and vectors encoding the chimeric receptors.
    Type: Application
    Filed: August 24, 2001
    Publication date: July 24, 2003
    Inventors: Brian Seed, Babak Banapour, Charles Romeo, Waldemar Kolanus
  • Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
    Patent number: 6284240
    Abstract: Disclosed is a method of directing a cellular immune response against an HIV-infected cell in a mammal involving administering to the mammal an effective amount of therapeutic cells which express a membrane-bound, proteinaceous chimeric receptor comprising (a) an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection and (b) an intracellular portion which is capable of signalling the therapeutic cell to destroy the receptor-bound HIV-infected cell. Also disclosed are cells which express the chimeric receptors and DNA and vectors encoding the chimeric receptors.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: September 4, 2001
    Assignee: The General Hospital Corporation
    Inventors: Brian Seed, Babak Banapour, Charles Romeo, Waldemar Kolanus
  • Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
    Patent number: 5851828
    Abstract: Disclosed is a method of directing a cellular immune response against an HIV-infected cell in a mammal involving administering to the mammal an effective amount of therapeutic cells which express a membrane-bound, proteinaceous chimeric receptor comprising (a) an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection and (b) an intracellular portion which is capable of signalling the therapeutic cell to destroy the receptor-bound HIV-infected cell. Also disclosed are cells which express the chimeric receptors and DNA and vectors encoding the chimeric receptors.
    Type: Grant
    Filed: August 2, 1994
    Date of Patent: December 22, 1998
    Assignee: The General Hospital Corporation
    Inventors: Brian Seed, Babak Banapour, Charles Romeo, Waldemar Kolanus