Abstract: A Multimodality Brain Mapping System (MBMS), comprising one or more scopes (e.g., microscopes or endoscopes) coupled to one or more processors, wherein the one or more processors obtain training data from one or more first images and/or first data, wherein one or more abnormal regions and one or more normal regions are identified; receive a second image captured by one or more of the scopes at a later time than the one or more first images and/or first data and/or captured using a different imaging technique; and generate, using machine learning trained using the training data, one or more viewable indicators identifying one or abnormalities in the second image, wherein the one or more viewable indicators are generated in real time as the second image is formed. One or more of the scopes display the one or more viewable indicators on the second image.

Abstract: A Multimodality Brain Mapping System (MBMS), comprising one or more scopes (e.g., microscopes or endoscopes) coupled to one or more processors, wherein the one or more processors obtain training data from one or more first images and/or first data, wherein one or more abnormal regions and one or more normal regions are identified; receive a second image captured by one or more of the scopes at a later time than the one or more first images and/or first data and/or captured using a different imaging technique; and generate, using machine learning trained using the training data, one or more viewable indicators identifying one or abnormalities in the second image, wherein the one or more viewable indicators are generated in real time as the second image is formed. One or more of the scopes display the one or more viewable indicators on the second image.

Abstract: An ablation probe which includes a probe body with a distal and proximal end, an ablation tip at the distal end of the probe body, an anode provided proximate to the ablation tip, a coaxial cable disposed within the probe body and coupled to the ablation tip and anode so that electromagnetic energy of a predetermined frequency is communicated thereto for dielectric heating of tissue, and a Parylene C coating on at least the ablation tip and anode to electrically isolate the ablation tip and anode from tissue without interference with microwave energy transmission through the probe to the tissue. The Parylene C is a vapor deposited coating on at least the ablation tip and anode to electrically isolate the ablation tip and anode from tissue.

Abstract: A medical imaging system and method. A UV/visible camera uses a back illuminated silicon imaging detector to observe a surface of a brain of a subject in vivo during brain surgery for excision of a cancerous tumor. The detector can be a CCD detector or a CMOS detector. Under UV illumination, the camera can record images that can be processed to detect the location and extent of a cancerous tumor because the presence of auto-fluorescent NADH variations can be detected between normal and cancerous cells. The image data is processed in a general purpose programmable computer. In some instances, an image is also taken using visible light, and the identified cancerous region is displayed as an overlay on the visible image.

Abstract: A device for assessing the effects of diffusible molecules on electrophysiological recordings from multiple neurons allows for the infusion of reagents through a cannula located among an array of microelectrodes. The device can easily be customized to target specific neural structures. It is designed to be chronically implanted so that isolated neural units and local field potentials are recorded over the course of several weeks or months. Multivariate statistical and spectral analysis of electrophysiological signals acquired using this system could quantitatively identify electrical “signatures” of therapeutically useful drugs.

Abstract: An apparatus for simultaneously measuring electrophysiological signals in a target tissue and for infusing an agent into the target tissue comprises a body, a cannula mounted on the body, and at least one electrophysiological electrode in proximity to the cannula and mounted on the body so that the agent supplied to the cannula is provided to the proximity of the target tissue with which the at least one electrophysiological electrode is electrically coupled. The cannula and electrode are arranged and configured with respect to each in a selected configuration to allow the apparatus to be customized for optimal implantation in specific neurological sites.