Abstract: System for enhancing the optical transparency of biological tissue covered by a surface permeability barrier of tissue, involving the delivery of a clarifying agent to the target biological tissue to alter the attenuation characteristics of the target biological tissue.

Abstract: System for enhancing the optical transparency of biological tissue covered by a surface permeability barrier of tissue, involving the delivery of a clarifying agent to the target biological tissue to alter the attenuation characteristics of the target biological tissue.

Abstract: Systems and methods for photobiomodulation of biological processes using invasive or non-invasive chemical clarification of biological tissues are provided to improve optical transmission of light energy in sub-epidermal tissue. The chemical clarification of in vivo biological tissues provides at least partial optical clarification of such tissues by applying a clarifying agent to the sub-epidermal tissue to temporarily replace water and other fluids from such tissues. Light energy is then applied to the clarified tissues, providing for deeper penetration of the light energy and more effective photobiomodulation. Lower power and wavelengths of light can be administered at high fluences into the tissue, at greater depths, and induce biological effects that are more pronounced than previously observed.

Abstract: Contemplated methods and compositions use selected agents to clarify biological tissues, and particularly tissues in vivo. In especially preferred aspects, the clarification agent is topically applied to clarify a plurality of layers, wherein the dermal layer that includes a target object remains unclarified. Light energy is then applied to the skin in an amount and under a protocol effective to destroy or alter the target object such that all skin layers avoid thermal damage. For example, hair follicles, collagen, and/or tattoo pigments located in the dermal reticular layer of skin are irradiated under a protocol in which the dermal papillary layer and all epidermal layers are clarified while the dermal reticular layer remains unclarified. Remarkably, such protocol significantly reduces thermal damage in the dermis, epidermis, and hypodermis.

Abstract: Contemplated methods and compositions use selected agents to clarify biological tissues, and particularly tissues in vivo. In especially preferred aspects, the clarification agent is topically applied to clarify a plurality of layers, wherein the dermal layer that includes a target object remains unclarified. Light energy is then applied to the skin in an amount and under a protocol effective to destroy or alter the target object such that all skin layers avoid thermal damage. For example, hair follicles, collagen, and/or tattoo pigments located in the dermal reticular layer of skin are irradiated under a protocol in which the dermal papillary layer and all epidermal layers are clarified while the dermal reticular layer remains unclarified. Remarkably, such protocol significantly reduces thermal damage in the dermis, epidermis, and hypodermis.

Abstract: Method and apparatus for enhancing the optical transparency of biological tissue covered by a surface permeability barrier of tissue, involving the delivery of a clarifying agent to the target biological tissue to alter the attenuation characteristics of the target biological tissue.

Abstract: Method and apparatus for enhancing the optical transparency of biological tissue covered by a surface permeability barrier of tissue, involving the delivery of a clarifying agent to the target biological tissue to alter the attenuation characteristics of the target biological tissue.

Abstract: Method and apparatus for enhancing the optical transparency of biological tissue covered by a surface permeability barrier of tissue, involving the delivery of a clarifying agent to the target biological tissue to alter the attenuation characteristics of the target biological tissue.

Abstract: Method and apparatus for enhancing the optical transparency of biological tissue covered by a surface permeability barrier of tissue, involving the delivery of a clarifying agent to the target biological tissue to alter the attenuation characteristics of the target biological tissue.