Patents by Inventor Babette-Yvonne Koegel

Babette-Yvonne Koegel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination of selected analgesics and COX-II inhibitors
    Patent number: 10471079
    Abstract: Combinations of certain analgesics with COX-II inhibitors, related pharmaceutical compositions, including advantageous galenical forms containing these combinations, and the use of such combinations in methods of treatment, in particular for the treatment of pain.
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: November 12, 2019
    Assignee: GRUENENTHAL GMBH
    Inventors: Klaus Schiene, Guenter Haase, Babette-Yvonne Koegel, Elmar Friderichs, Ulrich Jahnel
  • Substituted azaspiro(4.5)decane derivatives
    Patent number: 10214520
    Abstract: The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the ? opioid receptor and/or the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: February 26, 2019
    Assignee: GRUENENTHAL GMBH
    Inventors: Anita Wegert, Sven Kuehnert, Rene Michael Koenigs, Bert Nolte, Klaus Linz, Stephanie Harlfinger, Babette-Yvonne Koegel, Paul Ratcliffe, Fritz Theil, Olga Groeger, Birgit Braun
  • Substituted azaspiro(4.5)decane derivatives
    Patent number: 10202345
    Abstract: The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the ? opioid receptor and the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: February 12, 2019
    Assignee: GRUENENTHAL GMBH
    Inventors: Anita Wegert, Bert Nolte, Klaus Linz, Stephanie Harlfinger, Babette-Yvonne Koegel, Paul Ratcliffe, Fritz Theil, Olga Groeger, Birgit Braun
  • Process or preparing spirocyclic cyclohexane compounds, compositions containing such compounds and method of using such compounds
    Patent number: 9862719
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: January 9, 2018
    Assignee: Gruenenthal GmbH
    Inventors: Claudia Hinze, Otto Aulenbacher, Bernd Sundermann, Stefan Oberboersch, Elmar Friderichs, Werner Englberger, Babette-Yvonne Koegel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Valerie Sarah Rose, Michael Jonathan Lipkin
  • Substituted Azaspiro(4.5)Decane Derivatives
    Publication number: 20170210734
    Abstract: The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the ? opioid receptor and/or the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.
    Type: Application
    Filed: July 14, 2015
    Publication date: July 27, 2017
    Applicant: Gruenenthal GmbH
    Inventors: Anita WEGERT, Sven KUEHNERT, Rene Michael KOENIGS, Bert NOLTE, Klaus LINZ, Stephanie HARLFINGER, Babette-Yvonne KOEGEL, Paul RATCLIFFE, Fritz THEIL, Olga GROEGER, Birgit BRAUN
  • Combination of Selected Analgesics and Cox-II Inhibitors
    Publication number: 20160279150
    Abstract: Combinations of certain analgesics with COX-II inhibitors, related pharmaceutical compositions, including advantageous galenical forms containing these combinations, and the use of such combinations in methods of treatment, in particular for the treatment of pain.
    Type: Application
    Filed: June 7, 2016
    Publication date: September 29, 2016
    Inventors: Klaus SCHIENE, Guenter HAASE, Babette-Yvonne KOEGEL, Elmar FRIDERICHS, Ulrich JAHNEL
  • Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency
    Publication number: 20160271107
    Abstract: Spirocyclic cyclohexane compounds useful in pharmaceutical compositions for use in the treatment of substance dependency.
    Type: Application
    Filed: May 31, 2016
    Publication date: September 22, 2016
    Inventors: Elmar FRIDERICHS, Babette-Yvonne KOEGEL, Klaus LINZ
  • Substituted Azaspiro(4.5)Decane Derivatives
    Publication number: 20160016903
    Abstract: The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the ? opioid receptor and the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.
    Type: Application
    Filed: July 15, 2015
    Publication date: January 21, 2016
    Inventors: Anita WEGERT, Bert NOLTE, Klaus LINZ, Stephanie HARLFINGER, Babette-Yvonne KOEGEL, Paul RATCLIFFE, Fritz THEIL, Olga GROEGER, Birgit BRAUN
  • Mixed ORL1/mu-agonists for the Treatment of Pain
    Publication number: 20150342929
    Abstract: The invention relates to the use of compounds which exhibit an affinity for the ?-opioid receptor of at least 100 nM (Ki value, human) and an affinity for the ORL-1 receptor, wherein the ratio between the affinities ORL1/? defined as 1/[Ki(ORL1)/Ki(?)] is from 0.1 to 30, for the treatment of pain.
    Type: Application
    Filed: June 5, 2015
    Publication date: December 3, 2015
    Inventors: Klaus LINZ, Babette-Yvonne KOEGEL, Wolfgang SCHROEDER, Thomas CHRISTOPH, Jean De VRY, Elmar FRIDERICHS
  • Process for Preparing Spirocyclic Cyclohexane Compounds, Compositions Containing Such Compounds and Method of Using Such Compounds
    Publication number: 20150322080
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.
    Type: Application
    Filed: July 21, 2015
    Publication date: November 12, 2015
    Inventors: Claudia HINZE, Otto AULENBACHER, Bernd SUNDERMANN, Stefan OBERBOERSCH, Elmar FRIDERICHS, Werner ENGLBERGER, Babette-Yvonne KOEGEL, Klaus LINZ, Hans SCHICK, Helmut SONNENSCHEIN, Birgitta HENKEL, Valerie Sarah ROSE, Michael Jonathan LIPKIN
  • Process for preparing spirocyclic cyclohexane compounds, compositions containing such compounds and method of using such compounds
    Patent number: 9120797
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: September 1, 2015
    Assignee: Gruenenthal GmbH
    Inventors: Claudia Hinze, Otto Aulenbacher, Bernd Sundermann, Stefan Oberboersch, Elmar Friderichs, Werner Englberger, Babette-Yvonne Koegel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Valerie Sarah Rose, Michael Jonathan Lipkin
  • Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency
    Publication number: 20140303125
    Abstract: Spirocyclic cyclohexane compounds useful in pharmaceutical compositions for use in the treatment of substance dependency.
    Type: Application
    Filed: June 20, 2014
    Publication date: October 9, 2014
    Inventors: Elmar FRIDERICHS, Babette-Yvonne KOEGEL, Klaus LINZ
  • Method of treating pain caused by inflammation
    Patent number: 8618177
    Abstract: A method of treating or inhibiting, in particular, pain caused by inflammation in a mammal by administering to the mammal an effective inflammatory pain alleviating amount of a (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol compound or a physiologally acceptable salt thereof, such as the hydrochloride or citrate salt.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: December 31, 2013
    Assignee: Gruenenthal GmbH
    Inventors: Klaus Schiene, Guenter Haase, Babette-Yvonne Koegel, Elmar Friderichs, Ulrich Jahnel
  • Use of 1 phenyl-3-dimethylamino-propane compounds for treating neuropathic pain
    Patent number: 8536130
    Abstract: Use of 1-phenyl-3-dimethylaminopropane compounds for the production of medicaments for treating neuropathic pain, preferably polyneuropathic pain, also preferably diabetic neuropathic pain, more preferably diabetic peripheral neuropathic pain, and furthermore preferably for treating diabetic peripheral neuropathy.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: September 17, 2013
    Assignee: Gruenenthal GmbH
    Inventors: Thomas Christoph, Elmar Friderichs, Babette-Yvonne Koegel, Murielle Meen
  • Combination of selected analgesics and COX-II inhibitors
    Patent number: 8420691
    Abstract: Combinations of certain analgesics with COX-II inhibitors, related pharmaceutical compositions, including advantageous galenical forms containing these combinations, and the use of such combinations in methods of treatment, in particular for the treatment of pain.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: April 16, 2013
    Assignee: Gruenenthal GmbH
    Inventors: Klaus Schiene, Guenter Haase, Babette-Yvonne Koegel, Elmar Friderichs, Ulrich Jahnel
  • Method of inhibiting inflammatory pain
    Patent number: 8404749
    Abstract: A method of treating or inhibiting, in particular, pain caused by inflammation in a mammal by administering to the mammal an effective inflammatory pain alleviating amount of a (1R,2R)-3-(2-dimethylaminomethyl-cyclohexyl)-phenol compound or a physiologically acceptable salt thereof, such as the hydrochloride or citrate salt.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: March 26, 2013
    Assignee: Gruenenthal GmbH
    Inventors: Klaus Schiene, Guenter Haase, Babette-Yvonne Koegel, Elmar Friderichs, Ulrich Jahnel
  • Spirocyclic azaindole derivatives
    Patent number: 8399503
    Abstract: The invention relates to substituted azaindole derivatives, to methods for the production thereof, to medicaments containing said compounds and to the use of substituted azaindole derivatives for producing medicaments.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: March 19, 2013
    Assignee: Gruenenthal GmbH
    Inventors: Saskia Zemolka, Stefan Schunk, Ellen Bergrath, Babette-Yvonne Kögel, Werner Englberger, Klaus Linz, Hans Schick
  • Substituted heteroaryl derivatives
    Patent number: 8138187
    Abstract: The invention relates to substituted heteroaryl derivatives, to methods for the production thereof, to medicaments containing said compounds and to the use of substituted heteroaryl derivatives for producing medicaments.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: March 20, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Saskia Zemolka, Stefan Schunk, Werner Englberger, Babette-Yvonne Kögel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Heinz Graubaum, Claudia Hinze
  • Spirocyclic cyclohexane compounds with analgesic activity
    Patent number: 8124788
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a process for manufacturing such compounds, pharmaceutical compositions that contain such compounds, and the use of such spirocyclic cyclohexane compounds for the production of pharmaceuticals, and particularly for the treatment of pain.
    Type: Grant
    Filed: October 27, 2008
    Date of Patent: February 28, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Beatrix Merla, Stefan Oberboersch, Bernd Sundermann, Werner Englberger, Hagen-Heinrich Hennies, Babette-Yvonne Koegel, Stephan Schunk, Heinz Graubaum
  • Process for Preparing Spirocyclic Cyclohexane Compounds, Compositions Containing Such Compounds and Method of Using Such Compounds
    Publication number: 20110319440
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.
    Type: Application
    Filed: September 2, 2011
    Publication date: December 29, 2011
    Applicant: GRUENENTHAL GmbH
    Inventors: Claudia HINZE, Otto Aulenbacher, Bernd Sundermann, Stefan Oberboersch, Elmar Friderichs, Werner Englberger, Babette-Yvonne Koegel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Valerie Sarah Rose, Michael Jonathan Lipkin