Patents by Inventor Babru B. Samal

Babru B. Samal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
    Patent number: 5795569
    Abstract: Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands or thrombopoietin, that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately to result in the production of platelets. MGDF derivatives comprising MGDF molecules attached to water soluble polymers, such as polyethylene glycol, are also disclosed, along with methods for their preparation. Also disclosed are processes for obtaining the MGDFs in homogeneous form from natural sources and producing them by recombinant genetic engineering techniques from mammals, including humans.
    Type: Grant
    Filed: October 12, 1994
    Date of Patent: August 18, 1998
    Assignee: Amgen Inc.
    Inventors: Timothy D. Bartley, Jakob M. Bogenberger, Robert A. Bosselman, Pamela Hunt, Olaf B. Kinstler, Babru B. Samal
  • Method for treating mammals with monopegylated proteins that stimulates megakaryocyte growth and differentiation
    Patent number: 5766581
    Abstract: Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands), that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately to result in the production of platelets. MGDF derivatives comprising MGDF molecules attached to water soluble polymers, such as polyethylene glycol, are also disclosed, along with methods for their preparation. The MGDF proteins and derivatives are useful in methods for treating mammals to increase platelets and/or megakaryocytes. Also disclosed are processes for obtaining the MGDFs in homogeneous form from natural sources and producing them by recombinant genetic engineering techniques from mammals, including humans.
    Type: Grant
    Filed: March 30, 1995
    Date of Patent: June 16, 1998
    Assignee: Amgen Inc.
    Inventors: Timothy D. Bartley, Jakob M. Bogenberger, Robert A. Bosselman, Pamela Hunt, Olaf B. Kinstler, Babru B. Samal
  • Nucleic acid encoding the progenitor B cell stimulating factor
    Patent number: 5580754
    Abstract: A progenitor B cell stimulating factor which promotes the formation of pre-B cells is described. DNA sequences encoding same and methods of production and purification of the factor are also disclosed. The factor is used in the treatment of hematopoietic disorders and in bone marrow transplantation.
    Type: Grant
    Filed: August 23, 1994
    Date of Patent: December 3, 1996
    Assignee: Amgen Inc.
    Inventor: Babru B. Samal
  • Proteolytic enzymes
    Patent number: 5278062
    Abstract: This disclosure relates to a novel class of serine proteases isolated from a culture medium of fungus Tritirachium album. The serine proteases disclosed have a high degree of stability in detergent formulations.In addition, this disclosure relates to a process for producing such serine proteases using recombinant techniques.
    Type: Grant
    Filed: May 1, 1992
    Date of Patent: January 11, 1994
    Assignee: Amgen
    Inventors: Babru B. Samal, Yitzhak Stabinsky