Abstract: A fabricated structure for use with an associated marking device is provided. In one form, the fabricated structure includes a self-lifting spring finger having a nib for marking.

Abstract: An improved method and apparatus for delivering medication to the lungs is described. Acoustic ink printing technology is modified to operate as an inhaler that generates tiny droplets near a patient's nose or mouth. The tiny droplets are easily carried by air currents into the patient's lungs. The inhaler itself is preferably a battery operated portable device that can be easily carried and easily cleaned to avoid contaminating the medication.

Abstract: A fabricated structure for use with an associated marking device is provided. In one form, the fabricated structure includes a self-lifting spring finger having a nib for marking.

Abstract: Various fluidic techniques can employ ducting structures, such as microstructures, that extend between other components, such as plate-like structures. A ducting structure can, for example, include an inlet opening toward or near one plate-like structure, an outlet opening toward or near another plate-like structure, and a duct in which fluid flows after being received through the inlet opening and before being provided through the outlet opening. In some implementations, a ducting structure is photo-defined, such as by exposing a photoimageable structure and then removing either exposed or unexposed regions. In some implementations, a ducting structure is a freestanding polymer microstructure. In some implementations, ducting structures are microstructures that extend approximately the same length between first and second plate-like structures, and have a ratio of length to maximum cavity diameter of approximately two or more.

Abstract: In accordance with one aspect of the present exemplary embodiment, provided is a hand-held printer system and method for printing on a target. The system includes a hand-held printer, a target position sensing system which senses a position of the target, and a hand-held printer position sensing system which senses a position of the hand-held printer relative to a printing surface of the target. A control mechanism actuates the printing of the hand-held printer based on the sensed positions.

Abstract: An improved method and apparatus for delivering medication to the lungs is described. Acoustic ink printing technology is modified to operate as an inhaler that generates tiny droplets near a patient's nose or mouth. The tiny droplets are easily carried by air currents into the patient's lungs. The inhaler itself is preferably a battery operated portable device that can be easily carried and easily cleaned to avoid contaminating the medication.

Abstract: Provided is a priming mechanism for priming a biofluid drop ejection device having a drop ejection opening leading to an ejection reservoir. The priming mechanism includes a vacuum unit which generates a vacuum force, connected to a vacuum nozzle. The vacuum nozzle is located over the drop ejection opening. A disposable sleeve or tubing is attached to the vacuum nozzle and is placed in operational contact with the drop ejection opening. A fluid height detection sensor is positioned to sense a fluid height within at least one of the disposable tubing and the vacuum nozzle. Upon sensing a predetermined fluid height, by the fluid height detection sensor, the priming operation is completed, and the primer mechanism is removed from the operational contact with the drop ejection opening.

Abstract: Methods for testing proper operation of drop ejection units in a multi-ejector system are provided to determine whether the drop ejectors have been properly filled and/or the ejectors are emitting fully formed droplets. The methods include testing the ejectors prior to drop ejection. In this method, a priming system is used wherein fluid received by the priming system is ejected onto a test substrate to allow a scanner to determine the existence of the fluids at selected locations. The selected locations are correlated to the drop ejection units to determine which ejection units do not have biofluid or sufficient biofluid. A further method allows for ejection prior to printing, on a test substrate wherein testing for both the fullness of the ejector units as well as proper emission of the ejectors of droplets may be tested. The ejectors after being primed, eject the biofluids which are then scanned and correlated to each individual ejector.

Abstract: A biofluid drop ejection unit for ejecting biofluid drops. A biofluid drop ejection mechanism of such a unit includes a transducer, which generates energy used to emit the biofluid drop. Further provided is a reagent cartridge or biofluid containment area which holds the biofluid. The reagent cartridge or biofluid containment area is configured to hold low volumes of biofluid and to avoid contamination of the biofluid. The reagent cartridge or biofluid containment area is in operational connection with the drop ejection mechanism such that upon operation of the drop ejection mechanism, biofluid drops are emitted. The biofluid drop ejection mechanism is a high efficiency device, and may be configured as two separate pieces or as a single disposable unit.

Abstract: The cantilever of a probe-based metrology instrument such as an AFM is deflected by directing a beam of ultrasonic energy at the cantilever to apply ultrasonically generated acoustic radiation pressure to the cantilever. The energy is generated by an ultrasonic actuator such as a ZnO transducer driven by a power source such an RF signal generator. The transmitted beam preferably is shaped by focusing, collimation, or the like so that it impinges at least primarily on a region of interest of the cantilever such as the free end. The ultrasonic actuator produces a much better controlled force on the cantilever than can be achieved through the use of a traditional piezoelectric actuator and, accordingly, produces a response free of spurious effects (at least when the cantilever is operating in liquid). It also has a frequency bandwidth in the MHz range.

Abstract: Low acoustic solid wave attenuation structures are formed with an electroformed nickel mold, and are incorporated within acoustic ink emitters, between the focusing lens and surface of an ink layer. The structures have characteristics of low attenuation of acoustic waves to increase the efficiency of acoustic wave transmission within the acoustic ink emitter. Using the described structures, acoustic ink printers can accurately emit materials having high viscosity, including hot melt inks.

Abstract: A level control mechanism is provided for a biofluid drop ejection device which ejects biofluid drops in small volumes. The biofluid drop device includes a drop ejection mechanism having a transducer which generates energy used to emit the biofluid drops. A reagent cartridge or biofluid holding area holds a biofluid, isolated from the drop ejection mechanism to avoid contamination between the biofluid drop ejection mechanism and the reagent cartridge. The reagent cartridge is connected to the drop ejection mechanism such that upon operation of the mechanism, the biofluid is emitted in controlled biofluid drops. A level sensor is positioned to sense a height of the biofluid within the cartridge. Upon sensing the height of the biofluid below a certain level, an adjustment is made to the height by providing at least one of additional biofluid to the cartridge, and raising the level of the entire reagent cartridge.

Abstract: An inhaler that uses capillary effects to output droplets of pharmaceutical product is described. The inhaler includes transducers and lenses to generate focused acoustic waves. The frequency and pulse width output of the transducers are set to cause capillary action in a reservoir of pharmaceutical product. The capillary action results in the ejection of small droplets of pharmaceutical product at low frequencies.

Abstract: An at least two-pass acoustic printing system uses an acoustic printhead having an array of ejectors arranged in rows and columns. Operation of each ejector is individually controllable. To minimize cross-talk errors a first selected ejector in a selected row is identified as an odd ejector of the selected row. Thereafter a first firing sequence of the first selected ejector is generated based on the first selected ejector being identified as odd. Then a second ejector, immediately adjacent the first ejector, is selected and is identified as an even ejector. Thereafter a second firing sequence is generated for the second selected ejector based on the selector being identified as even. The first and second firing sequences result in the first ejector and the second ejector being active during non-concurrent time periods. When a defective ejector of the array is detected, an operable ejector firing to the same substrate area is determined.

Abstract: An at least two-pass acoustic printing system uses an acoustic printhead having an array of ejectors arranged in rows and columns. Operation of each ejector is individually controllable. To minimize cross-talk errors a first selected ejector in a selected row is identified as an odd ejector of the selected row. Thereafter a first firing sequence of the first selected ejector is generated based on the first selected ejector being identified as odd. Then a second ejector, immediately adjacent the first ejector, is selected and is identified as an even ejector. Thereafter a second firing sequence is generated for the second selected ejector based on the selector being identified as even. The first and second firing sequences result in the first ejector and the second ejector being active during non-concurrent time periods. When a defective ejector of the array is detected, an operable ejector firing to the same substrate area is determined.

Abstract: The cantilever of a probe-based metrology instrument such as an AFM is deflected by directing a beam of ultrasonic energy at the cantilever to apply ultrasonically generated acoustic radiation pressure to the cantilever. The energy is generated by an ultrasonic actuator such as a ZnO transducer driven by a power source such an RF signal generator. The transmitted beam preferably is shaped by focusing, collimation, or the like so that it impinges at least primarily on a region of interest of the cantilever such as the free end. The ultrasonic actuator produces a much better controlled force on the cantilever than can be achieved through the use of a traditional piezoelectric actuator and, accordingly, produces a response free of spurious effects (at least when the cantilever is operating in liquid). It also has a frequency bandwidth in the MHz range.

Abstract: A method and mechanism for ensuring quality control in printed biological assays is provided. A multi-ejector system having a plurality of individual drop ejectors is loaded with a variety of biofluids. Biofluids include at least a carrier fluid, a biological material to be used in the testing, and markers, such as fluorescent dyes. Data regarding the biofluid loaded in each of the drop ejectors is stored along with an expected signature output of the biofluid. Particularly, the signature output represents signals from individual ones of the fluorescent markers included within the biofluid. Once a biological assay consisting of the biofluid drops has been printed, a scanner capable of detecting the markers scans the biological assay and obtains signature output signals for each of the drops of the biological assay.

Abstract: A multiple-ejector system for printing arrays of biofluids include a tooling plate having a plurality of sets of tooling pins extending outward from the surface of the tooling plate. A printed circuit board is provided having pairs of power connection pins and ground return pins extending from a surface of the circuit board. A plurality of biofluid drop ejection units are provided and include alignment grooves and at least a transducer. Each of the plurality of biofluid drop ejection units are connected to a corresponding one of a set of tooling pins by connection of the tooling pins and alignment grooves. The power connection pins of the pairs are in operational connection with respective transducers and the ground return connection pins of the pairs are in operational connection with a body portion of the drop ejection units. The different drop ejection units will contain different biofluids which are to be emitted onto a substrate.

Abstract: A number of architectures of switch compensation networks are described for the provision of a compensation current which ensures the maintaining of a desired switching ratio in an acoustic printhead. The described architectures include those which provide column compensation, row compensation, and row and column compensation to a transducer switching matrix. Control of the switching ratio by the compensation networks, is used in consideration of the dissipation of heat energy through expulsion of a heated drop, to provide a precisely controlled balance.

Abstract: A method and mechanism for ensuring quality control in printed biological assays is provided. A multi-ejector system having a plurality of individual drop ejectors is loaded with a variety of biofluids. Biofluids include at least a carrier fluid, a biological material to be used in the testing, and markers, such as fluorescent dyes. Data regarding the biofluid loaded in each of the drop ejectors is stored along with an expected signature output of the biofluid. Particularly, the signature output represents signals from individual ones of the fluorescent markers included within the biofluid. Once a biological assay consisting of the biofluid drops has been printed, a scanner capable of detecting the markers scans the biological assay and obtains signature output signals for each of the drops of the biological assay.