Abstract: An imaging catheter assembly comprising a catheter comprising: a proximal end; a distal end; a tubular body extending from the proximal end to the distal end; and an imaging element within the tubular body; a sheath comprising: a proximal end; a distal end; and a tubular body extending from the proximal end to the distal end, the tubular body having an inner surface, wherein the inner surface of the tubular body of the sheath at least partially defines a conduit for conveying a fluid to the distal end of the sheath, and wherein the sheath is movable such that the distal end of the sheath is positionable relative to the distal end of the catheter.

Abstract: An apparatus includes an elongate member having proximal and distal portions; a rotatable drive cable disposed within the elongate member, the drive cable being connectable to a mechanism to which torque can be applied; and a control assembly mechanically coupled to the drive cable, and configured to disengage the mechanism from the drive cable when the applied torque exceeds a predetermined level, wherein disengagement of the mechanism from the drive cable causes rotation of the drive cable to stop or withdrawal of the drive cable.

Abstract: Some embodiments of a device comprise a sheath, a first light-guiding component, a second light-guiding component, an optical-focusing component, and an optical-correction component. The second light-guiding component and the optical-focusing component are aligned on an optical axis. Also, the optical-correction component does not directly contact the optical-focusing component, and the optical-correction component is not positioned on the optical axis.

Abstract: Some embodiments of a device comprise a light-guiding component; an optical-focusing component, wherein the light-guiding component and the optical-focusing component are aligned on an optical axis; and an optical-correction component that includes a reflecting surface and a correction surface.

Abstract: One or more devices, systems, methods and storage mediums for performing optical coherence tomography (OCT) while reducing and/or eliminating crosstalk noise are provided. Examples of such applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, for Gastro-intestinal, cardio and/or ophthalmic applications, and being obtained via one or more optical instruments, such as, but not limited to, optical probes, catheters, capsules and needles (e.g., a biopsy needle). Preferably, the OCT devices, systems methods and storage mediums include or involve a method, such as, but not limited to, a complex conjugate method or a shift method, for handling the crosstalk noise in a way to mitigate or eliminate the noise from an image field of view. For example, a reference reflection or reference arm may be positioned or re-positioned in the image field of view at different locations depending on the crosstalk noise mitigation method being employed.

Abstract: The present disclosure provides apparatuses and methods for color imaging and an increased field of view using spectrally encoded endoscopy techniques. At least one of the apparatuses includes an illumination unit having two or more spectrally dispersive gratings positioned, for example, on different planes or on the same plane but having grating vectors at an angle to each other such that bands of spectrally dispersed light propagating from the gratings propagate on different planes.

Abstract: One or more devices, systems, methods and storage mediums for characterizing, examining and/or diagnosing, and/or measuring viscosity of, a sample or object are provided herein. Such information may be obtained in application(s) using a system that includes a rotary junction, an elongated extender or at least one repeater attached to the rotary junction and a rotatable probe attached to the elongated extender and/or the at least one repeater. Examples of such applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, for Gastro-intestinal, cardio and/or ophthalmic applications, and being obtained via one or more optical instruments. The extenders and/or repeaters may be used with one or more forms of imaging, such as, but not limited to, Spectrally Encoded Endoscopy (“SEE”) and Optical Coherence Tomography (“OCT”).

Abstract: A multimodality system includes first and second modalities, a catheter, and a processor. The catheter collects fluorescent light from a plurality of locations of a sample which has been irradiated with excitation light of the second modality; a detector detects intensity of the fluorescent light received from the plurality of locations as a function of an angle ? formed between the normal to the sample surface and the optical axis of the excitation light. A processor calculates the angle ? at each of the plurality of locations based on radiation of the first modality incident on the sample, and corrects the intensity of the detected fluorescent light using a calibration factor g(?). The calibration factor g(?) is a function of the angle ? calculated at two or more of the plurality of locations. The angle ? is composed of a transversal angle ?t and an axial angle ?a.

Abstract: A method for processing an intravascular image including a plurality of image frames acquired during a pullback of an imaging catheter inserted into a vessel. The method includes obtaining positions of lumen borders detected in the intravascular image and positions of stent-struts detected in the intravascular image. Determining, at different positions in a range, a stent expansion value of the stent implanted in the vessel, based on the first information and the second information, wherein each image frame from image frames in which stent-struts are detected corresponds to a different position along the range. The method may also include displaying an image including positions of lumen borders and positions of the stent-struts detected and a first indicator indicating a level along the range, of the stent expansion value, with the image.

Abstract: An optical coherence tomography (OCT) system comprises an interferometer configured to generate interference light based on interference between a reference beam and a sample beam with which a sample has been irradiated. A detector operates to detect intensities of the interference light and/or one or more interference patterns; a processor is configured measure a signal falloff of the intensity of the interference light and/or the one or more interference patterns; and an optical delay line configured to adjust an optical path difference according to the signal falloff so as not substantially introduce artifacts to an image of the sample. In one embodiment, the optical delay line includes a main reflector consisting of a mirror and a Faraday rotator; the Faraday rotator is placed between the n and n+1 coherence revival modes of the interferometer, where n is greater than or equal to 1.

Abstract: Some devices comprise a first light-guiding component, a second light-guiding component, a lens, an optical-correction component that has a reflecting surface that faces the lens, and a sheath, which causes astigmatism. The reflecting surface has an optical power on a first axis of two orthogonal axes, the optical power on the first axis compensates for the astigmatism, and the reflecting surface has a negligible optical power on a second axis of the two orthogonal axes. Also, the reflecting surface is configured to reflect light from the lens and redirect the reflected light through the sheath.

Abstract: A rotation-free beam-steering device for manipulating probing and reflected optical beams includes at least one electrowetting cell having at least one side wall defining an inner space. The at least one side wall has a lining adjacent to the inner space. A liquid at least partially fills the inner space. The liquid has at least one controlled surface not in contact with the wall lining. The liquid further has a contact angle with the wall lining. The at least one controlled surface is disposed to interface with an optical beam exiting from a distal end of an optical fiber at an incidence angle. At least two electrodes are provided separated from the inner space by the lining. An electrical potential on the at least two electrodes is controlled to adjust the contact angle of the liquid bounding the at least one controlled surface.

Abstract: The disclosed automatic calibration systems and methods provide a repeatable way to detect internal catheter reflections and to shift the internal catheter reflections to calibrate an image.

Abstract: The present disclosure provides apparatuses and methods for color imaging and an increased field of view using spectrally encoded endoscopy techniques. At least one of the apparatuses includes an illumination unit having two or more spectrally dispersive gratings positioned, for example, on different planes or on the same plane but having grating vectors at an angle to each other such that bands of spectrally dispersed light propagating from the gratings propagate on different planes.

Abstract: One or more devices, systems, methods and storage mediums for performing optical coherence tomography (OCT) while reducing and/or eliminating crosstalk noise are provided. Examples of such applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, for Gastro-intestinal, cardio and/or ophthalmic applications, and being obtained via one or more optical instruments, such as, but not limited to, optical probes, catheters, capsules and needles (e.g., a biopsy needle). Preferably, the OCT devices, systems methods and storage mediums include or involve a method, such as, but not limited to, a complex conjugate method or a shift method, for handling the crosstalk noise in a way to mitigate or eliminate the noise from an image field of view. For example, a reference reflection or reference arm may be positioned or re-positioned in the image field of view at different locations depending on the crosstalk noise mitigation method being employed.

Abstract: One or more devices, systems, methods and storage mediums for performing common path optical coherence tomography (OCT) with a controlled reference signal and efficient geometric coupling are provided. Examples of such applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, for Gastro-intestinal, cardio and/or ophthalmic applications, and being obtained via one or more optical instruments, such as, but not limited to, optical probes (e.g., common path probes), common path catheters, common path capsules and common path needles (e.g., a biopsy needle). Preferably, the OCT devices, systems methods and storage mediums include or involve a reference reflection or a reference plane that is at least one of: (i) disposed in the collimation field or path; and (ii) is perpendicular (or normal) or substantially perpendicular (or substantially normal) to light propagation.

Abstract: This invention relates generally to the detection of objects, such as stents, within intraluminal images using principal component analysis and/or regional covariance descriptors. In certain aspects, a training set of pre-defined intraluminal images known to contain an object is generated. The principal components of the training set can be calculated in order to form an object space. An unknown input intraluminal image can be obtained and projected onto the object space. From the projection, the object can be detected within the input intraluminal image. In another embodiment, a covariance matrix is formed for each pre-defined intraluminal image known to contain an object. An unknown input intraluminal image is obtained and a covariance matrix is computed for the input intraluminal image. The covariances of the input image and each image of the training set are compared in order to detect the presence of the object within the input intraluminal image.

Abstract: Exemplary probes including longitudinal marker elements arranged parallel to the probe axis are provided for reducing or eliminating non-uniform rotational distortions (NURD) in imaging systems. Additional ring marker elements may also be provided to reduce or eliminate non-uniform linear distortion (NULD). These probes, as well as systems and methods of use provide for images having better image quality and reduced NURD.

Abstract: The disclosed automatic calibration systems and methods provide a repeatable way to detect internal catheter reflections and to shift the internal catheter reflections to calibrate an image.

Abstract: The disclosed automatic calibration systems and methods provide a repeatable way to detect internal catheter reflections and to shift the internal catheter reflections to calibrate an image.