Abstract: The present invention relates to a method for preparing a biomaterial having selectively functionalized tyrosine, a biomaterial having selectively functionalized tyrosine, and a pharmaceutical composition containing the same as an active ingredient. The method for preparing a biomaterial to which a compound represented by formula 2 is coupled, of the present invention, allows the compound represented by formula 2 to be selectively coupled, in a high yield in a biomaterial, to tyrosine, which is present on the surface of an aqueous solution such that the coupling thereof to amino acids other than tyrosine does not occur and, when only one tyrosine is present, heterogeneous mixtures are not present and the inherent activity of the biomaterial is maintained, and thus the compound can be effectively used as a pharmaceutical composition containing a biomaterial drug as an active ingredient.

Abstract: The present invention relates to a compound comprising an EZH2 inhibitor and an E3 ligase binder, and a pharmaceutical composition for preventing or treating EZH2-associated disease and a pharmaceutical composition for selective protein degradation containing the same as an active ingredient. Since the compound of the present invention can selectively degrade EZH2, it can be effectively used for the treatment of EZH2-related diseases and cancers, particularly, cancers in which EZH2 is overexpressed, and can be usefully used for the selective degradation of EZH2.

Abstract: The present disclosure relates to a cell implant for islet grafts and uses thereof. More specifically, the present disclosure provides a method for treating or preventing diabetes including administering a composition comprising a spheroid and an islet cluster as active ingredients to a subject in need thereof, and a method for preparing the cell implant. According to the present disclosure, the cell implant can reduce loss of the biological activity and function of islet cells and increase the viability of the islet cells. Therefore, the cell implant can improve the quality of the islet cells or maintain the quality for a long time and also improve angiogenic capacity, and, thus, can be used in treating diabetes.