Patents by Inventor Bahram Fathollahi
Bahram Fathollahi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10488321Abstract: Described here is a device comprising a microfluidic chip and an acoustic transducer external to the microfluidic chip, wherein the microfluidic chip comprises a channel in communication with a microwell having a volume less than one microliter, and wherein the acoustic transducer is coupled to the microfluidic chip via a coupling medium.Type: GrantFiled: March 18, 2016Date of Patent: November 26, 2019Assignees: The Board of Trustees of the Leland Stanford Junior University, Cella Genomics Inc.Inventors: Bahram Fathollahi, Daniel G. Stearns, William Whalen
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Publication number: 20180067038Abstract: Described here is a device comprising a microfluidic chip and an acoustic transducer external to the microfluidic chip, wherein the microfluidic chip comprises a channel in communication with a microwell having a volume less than one microliter, and wherein the acoustic transducer is coupled to the microfluidic chip via a coupling medium.Type: ApplicationFiled: March 18, 2016Publication date: March 8, 2018Applicants: The Board of Trustees of the Leland Stanford Junior University, Cella Genomics Inc.Inventors: Bahram Fathollahi, Daniel G. Stearns, William Whalen
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Patent number: 9420148Abstract: The invention provides a method and apparatus for isolating individual target cells. The apparatus includes a body structure comprising a main channel, a collection channel, and a waste channel fluidly coupled at a first fluid junction. A plurality of trapping channels intersect the collection channel, each trapping channel having a diameter at a location adjacent to the intersection of the trapping channel with the collection channel that is less than a diameter of an individual target cell. The apparatus also includes an imaging system configured to image individual target and non-target cells within the main channel, thereby producing imaging data; a processor configured to perform real-time, multivariate analyses of the imaging data; and a directing system configured to direct the individual target cells. A pressure source is in fluid communication with one or more of the collection channel, the waste channel, the first side channel, and the second side channel.Type: GrantFiled: October 19, 2015Date of Patent: August 16, 2016Assignee: CALIPER LIFE SCIENCES, INC.Inventors: Rajiv Bharadwaj, Bahram Fathollahi
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Publication number: 20160044212Abstract: The invention provides a method and apparatus for isolating individual target cells. The apparatus includes a body structure comprising a main channel, a collection channel, and a waste channel fluidly coupled at a first fluid junction. A plurality of trapping channels intersect the collection channel, each trapping channel having a diameter at a location adjacent to the intersection of the trapping channel with the collection channel that is less than a diameter of an individual target cell. The apparatus also includes an imaging system configured to image individual target and non-target cells within the main channel, thereby producing imaging data; a processor configured to perform real-time, multivariate analyses of the imaging data; and a directing system configured to direct the individual target cells. A pressure source is in fluid communication with one or more of the collection channel, the waste channel, the first side channel, and the second side channel.Type: ApplicationFiled: October 19, 2015Publication date: February 11, 2016Applicant: Caliper Life Sciences, Inc.Inventors: Rajiv Bharadwaj, Bahram Fathollahi
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Patent number: 9165359Abstract: The invention provides a method and apparatus for isolating individual target cells. The apparatus includes a body structure comprising a main channel, a collection channel, and a waste channel fluidly coupled at a first fluid junction. A plurality of trapping channels intersect the collection channel, each trapping channel having a diameter at a location adjacent to the intersection of the trapping channel with the collection channel that is less than a diameter of an individual target cell. The apparatus also includes an imaging system configured to image individual target and non-target cells within the main channel, thereby producing imaging data; a processor configured to perform real-time, multivariate analyses of the imaging data; and a directing system configured to direct the individual target cells. A pressure source is in fluid communication with one or more of the collection channel, the waste channel, the first side channel, and the second side channel.Type: GrantFiled: January 13, 2015Date of Patent: October 20, 2015Assignee: Caliper Life SciencesInventors: Rajiv Bharadwaj, Bahram Fathollahi
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Patent number: 9097723Abstract: The invention provides methods and apparatuses that allow a protein sample to undergo reduction, alkylation, and digestion in a continuous flow process carried out within a microfluidic device. Methods and apparatuses in accordance with the invention can be employed as part of an automated proteomics analysis carried out in an integrated proteomics system.Type: GrantFiled: April 3, 2006Date of Patent: August 4, 2015Assignee: Caliper Life Sciences, Inc.Inventors: Bahram Fathollahi, Javier A. Farinas, Andrea W. Chow, Stephane Mouradian
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Publication number: 20150193928Abstract: The invention provides a method and apparatus for isolating individual target cells. The apparatus includes a body structure comprising a main channel, a collection channel, and a waste channel fluidly coupled at a first fluid junction. A plurality of trapping channels intersect the collection channel, each trapping channel having a diameter at a location adjacent to the intersection of the trapping channel with the collection channel that is less than a diameter of an individual target cell. The apparatus also includes an imaging system configured to image individual target and non-target cells within the main channel, thereby producing imaging data; a processor configured to perform real-time, multivariate analyses of the imaging data; and a directing system configured to direct the individual target cells. A pressure source is in fluid communication with one or more of the collection channel, the waste channel, the first side channel, and the second side channel.Type: ApplicationFiled: January 13, 2015Publication date: July 9, 2015Applicant: CALIPER LIFE SCIENCES, INCInventors: Rajiv Bharadwaj, Bahram Fathollahi
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Patent number: 8934700Abstract: The invention provides a method and apparatus for isolating individual target cells. The apparatus includes a body structure comprising a main channel, a collection channel, and a waste channel fluidly coupled at a first fluid junction. A plurality of trapping channels intersect the collection channel, each trapping channel having a diameter at a location adjacent to the intersection of the trapping channel with the collection channel that is less than a diameter of an individual target cell. The apparatus also includes an imaging system configured to image individual target and non-target cells within the main channel, thereby producing imaging data; a processor configured to perform real-time, multivariate analyzes of the imaging data; and a directing system configured to direct the individual target cells. A pressure source is in fluid communication with one or more of the collection channel, the waste channel, the first side channel, and the second side channel.Type: GrantFiled: March 4, 2013Date of Patent: January 13, 2015Assignee: Caliper Life Sciences, Inc.Inventors: Rajiv Bharadwaj, Bahram Fathollahi
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Publication number: 20140247971Abstract: The invention provides a method and apparatus for isolating individual target cells. The apparatus includes a body structure comprising a main channel, a collection channel, and a waste channel fluidly coupled at a first fluid junction. A plurality of trapping channels intersect the collection channel, each trapping channel having a diameter at a location adjacent to the intersection of the trapping channel with the collection channel that is less than a diameter of an individual target cell. The apparatus also includes an imaging system configured to image individual target and non-target cells within the main channel, thereby producing imaging data; a processor configured to perform real-time, multivariate analyses of the imaging data; and a directing system configured to direct the individual target cells. A pressure source is in fluid communication with one or more of the collection channel, the waste channel, the first side channel, and the second side channel.Type: ApplicationFiled: March 4, 2013Publication date: September 4, 2014Applicant: CALIPER LIFE SCIENCES, INC.Inventors: Rajiv Bharadwaj, Bahram Fathollahi
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Publication number: 20060246533Abstract: The invention provides methods and apparatuses that allow a protein sample to undergo reduction, alkylation, and digestion in a continuous flow process carried out within a microfluidic device. Methods and apparatuses in accordance with the invention can be employed as part of an automated proteomics analysis carried out in an integrated proteomics system.Type: ApplicationFiled: April 3, 2006Publication date: November 2, 2006Applicant: Caliper Life Sciences, Inc.Inventors: Bahram Fathollahi, Javier Farinas, Andrea Chow, Stephane Mouradian
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Publication number: 20050027111Abstract: A method of characterizing a polypeptide, comprising providing a first capillary channel having a separation buffer disposed within, wherein the separation buffer comprises a non-crosslinked polymer solution, a buffering agent, a detergent, and a lipophilic dye. The separation buffer is provided such that, at the time of detection, the detergent concentration in the buffer is not above the critical micelle concentration. The polypeptide is introduced into one end of the capillary channel. An electric field is applied across a length of the capillary channel, which transports polypeptides of different sizes through the polymer solution at different rates. The polypeptide is then detected as it passes a point along the length of the capillary channel.Type: ApplicationFiled: January 30, 2004Publication date: February 3, 2005Applicant: Caliper Life Sciences, Inc.Inventors: Andrea Chow, Bahram Fathollahi, James Mikkelsen, Michael Spaid, Adrian Winoto