Abstract: A system and method for optimal disease treatment involving a disease management workflow for specific disease states, computer program products (that is, patient data repositories, workflow tools, and reports) to assist clinicians with the management of specific disease states, and the like for optimizing treatment and management of specific diseases. The system provides a workflow tool for a specific disease state that includes a pathway with decisions to be made by a clinician based on specific patient data from a repository and other patient information available to a clinician for treating a variety of medical conditions based on the up-to-date treatment information in order to provide patients with optimal treatment workflows for their specific medical conditions. A disease management pathway potentially includes parallel flows (also called “equal outcome variables”) where several drugs or other treatments have been shown to have substantially equal outcomes.