Patents by Inventor Bai Liu

Bai Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF
    Publication number: 20250136663
    Abstract: Provided herein are multi-chain chimeric polypeptides and uses thereof for treating cancer, aging related diseases or conditions, and/or an infectious disease. Further provided, are methods for stimulating an immune cell, inducing or increasing proliferation of an immune cell, and/or inducing differentitation of an immune cell into a memory-like immune cell by contacting the immune cell with the multi-chain chimeric polypeptides disclosed herein.
    Type: Application
    Filed: October 31, 2024
    Publication date: May 1, 2025
    Inventors: Hing C. Wong, Bai Liu, Xiaoyun Zhu, Varghese George, Pallavi Chaturvedi
  • IL-15-based molecules with anti-CD20 antibody and methods of use
    Patent number: 12268732
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: June 7, 2024
    Date of Patent: April 8, 2025
    Assignee: Altor Bioscience, LLC.
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • Compositions comprising IL-15N72D-based molecules and bacillus calmette-guerin (BCG)
    Patent number: 12268731
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: April 18, 2024
    Date of Patent: April 8, 2025
    Assignee: Altor Bioscience, LLC
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • METHODS OF GENERATING, STIMULATING, OR INCREASING PROLIFERATION OF DIFFERENT SUBSETS OF CD8+ T CELLS
    Publication number: 20250108112
    Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in generating, and/or stimulating, and/or increasing proliferation of different subsets of CD8+ T cells. Further, provided herein are pharmaceutical compositions comprising the multi-chain chimeric polypeptides. In addition, kits comprising the pharmaceutical compositions comprising the multi-chain chimeric polypeptides disclosed herein are also provided.
    Type: Application
    Filed: October 2, 2024
    Publication date: April 3, 2025
    Inventors: Hing C. Wong, Bai Liu, Niraj Shrestha
  • IL-15-based fusions to IL-12 and IL-18
    Patent number: 12233116
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Grant
    Filed: September 25, 2024
    Date of Patent: February 25, 2025
    Assignee: Altor Bioscience, LLC.
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • IL-15-BASED FUSIONS TO IL-12 AND IL-18
    Publication number: 20250018020
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Application
    Filed: September 25, 2024
    Publication date: January 16, 2025
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • METHODS OF TREATING AGING-RELATED DISORDERS
    Publication number: 20250011380
    Abstract: Provided herein are methods of killing or reducing the number of naturally-occurring and/or treatment-induced senescent cells and diseased cells in a subject in need thereof, decreasing the accumulation of naturally-occurring and/or treatment-induced senescent cells and diseased cells in a subject in need thereof, that include administering to the subject a therapeutically effective amount of one or more common gamma-chain family cytokine receptor activating agent(s) and/or one or more agent(s) that result(s) in a decrease in the activation of a TGF-? receptor.
    Type: Application
    Filed: July 1, 2024
    Publication date: January 9, 2025
    Applicant: HCW Biologics, Inc.
    Inventors: Hing C. Wong, Xiaoyun Zhu, Bai Liu, Pallavi Chaturvedi, Varghese George
  • IL-15-based molecules and methods of treating a neoplasia
    Patent number: 12186372
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: February 28, 2023
    Date of Patent: January 7, 2025
    Assignee: Altor Bioscience, LLC
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • Methods of treating a neoplasia with IL-15-based molecules and CTLA-4 antibody
    Patent number: 12097244
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: December 22, 2023
    Date of Patent: September 24, 2024
    Assignee: Altor BioScience, LLC.
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20240307494
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: June 7, 2024
    Publication date: September 19, 2024
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20240307495
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: June 7, 2024
    Publication date: September 19, 2024
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • METHOD FOR STIMULATING TUMOR-INFILTRATING LYMPHOCYTES WITH AN IL-15:IL-15R COMPLEX
    Publication number: 20240299498
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: May 30, 2024
    Publication date: September 12, 2024
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20240261373
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: April 18, 2024
    Publication date: August 8, 2024
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • COMPOSITIONS COMPRISING IL-15N72D-BASED MOLECULES AND BACILLUS CALMETTE-GUERIN (BCG)
    Publication number: 20240252591
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: April 18, 2024
    Publication date: August 1, 2024
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED FUSIONS TO IL-12 AND IL-18
    Publication number: 20240252609
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Application
    Filed: March 20, 2024
    Publication date: August 1, 2024
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • Methods of treating aging-related disorders
    Patent number: 12024545
    Abstract: Provided herein are methods of killing or reducing the number of naturally-occurring and/or treatment-induced senescent cells and diseased cells in a subject in need thereof, decreasing the accumulation of naturally-occurring and/or treatment-induced senescent cells and diseased cells in a subject in need thereof, that include administering to the subject a therapeutically effective amount of one or more common gamma-chain family cytokine receptor activating agent(s) and/or one or more agent(s) that result(s) in a decrease in the activation of a TGF-? receptor.
    Type: Grant
    Filed: June 1, 2021
    Date of Patent: July 2, 2024
    Assignee: HCW Biologics, Inc.
    Inventors: Hing C. Wong, Xiaoyun Zhu, Bai Liu, Pallavi Chaturvedi, Varghese George
  • Compositions comprising IL-15-based molecules and immune checkpoint inhibitor antibodies
    Patent number: 11992516
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: October 11, 2022
    Date of Patent: May 28, 2024
    Assignee: Altor Bioscience, LLC.
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-based fusions to IL-12 and IL-18
    Patent number: 11975059
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Grant
    Filed: December 1, 2023
    Date of Patent: May 7, 2024
    Assignee: Altor Bioscience, LLC.
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20240131115
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: December 22, 2023
    Publication date: April 25, 2024
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED FUSIONS TO IL-12 AND IL-18
    Publication number: 20240100138
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Application
    Filed: December 1, 2023
    Publication date: March 28, 2024
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong