Patents by Inventor Bai Liu

Bai Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20240131115
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: December 22, 2023
    Publication date: April 25, 2024
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • DIRECTLY COUPLED OPTICAL INTERPOSER
    Publication number: 20240111090
    Abstract: A device comprises a substrate and an IC die, which may be a photonic IC. The substrate comprises a first surface, a second surface opposite the first surface, an optical waveguide integral with the substrate, and a hole extending from the first surface to the second surface. The hole comprises a first sidewall. The optical waveguide is between the first surface and the second surface, parallel to the first surface, and comprises a first end which extends to the first sidewall. The IC die is within the hole and comprises a second sidewall and an optical port at the second sidewall. The second sidewall is proximate to the first sidewall and the first end of the optical waveguide is proximate to and aligned with the optical port. The substrate may include a recess to receive another device comprising a socket.
    Type: Application
    Filed: September 30, 2022
    Publication date: April 4, 2024
    Applicant: Intel Corporation
    Inventors: Robert A. May, Tarek Ibrahim, Shriya Seshadri, Kristof Darmawikarta, Hiroki Tanaka, Changhua Liu, Bai Nie, Lilia May, Srinivas Pietambaram, Zhichao Zhang, Duye Ye, Yosuke Kanaoka, Robin McRee
  • MICROELECTRONICS PACKAGES WITH PHOTO-INTEGRATED GLASS INTERPOSER
    Publication number: 20240112972
    Abstract: Disclosed herein are microelectronics package architectures utilizing photo-integrated glass interposers and photonic integrated glass layers and methods of manufacturing the same. The microelectronics packages may include an organic substrate, a photonic integrated glass layer, and a glass interpose. The organic substrate may define through substrate vias. The photonic integrated glass layer may be attached to the organic substrate. The photonic integrated glass layer may include photo detectors. The glass interposer may be attached to the organic substrate. The glass interposer may define through glass vias in optical communication with the photo detectors.
    Type: Application
    Filed: September 30, 2022
    Publication date: April 4, 2024
    Inventors: Hiroki Tanaka, Robert Alan May, Kristof Darmawikarta, Bai Nie, Brandon C. Marin, Jeremy D. Ecton, Srinivas Venkata Ramanuja Pietambaram, Changhua Liu
  • IL-15-BASED FUSIONS TO IL-12 AND IL-18
    Publication number: 20240100138
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Application
    Filed: December 1, 2023
    Publication date: March 28, 2024
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • Method for treating neoplasia with an anti-CD38 antibody and an IL-15:IL-15R complex
    Patent number: 11925676
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: February 27, 2023
    Date of Patent: March 12, 2024
    Assignee: Altor Bioscience, LLC.
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME
    Publication number: 20240076354
    Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
    Type: Application
    Filed: October 31, 2023
    Publication date: March 7, 2024
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-Ping Han
  • Method of treating cancer with composition comprising IL-15-based molecules and BCG
    Patent number: 11890323
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: December 9, 2022
    Date of Patent: February 6, 2024
    Assignee: Altor Bioscience, LLC
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-based fusions to IL-12 and IL-18
    Patent number: 11872272
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Grant
    Filed: February 13, 2023
    Date of Patent: January 16, 2024
    Assignee: Altor Bioscience, LLC
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • Multimeric IL-15 soluble fusion molecules and methods of making and using same
    Patent number: 11845783
    Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
    Type: Grant
    Filed: July 26, 2021
    Date of Patent: December 19, 2023
    Assignee: Altor Bioscience, LLC.
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-Ping Han
  • IL-15-BASED FUSIONS TO IL-12 AND IL-18
    Publication number: 20230248813
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Application
    Filed: February 13, 2023
    Publication date: August 10, 2023
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20230241174
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: December 9, 2022
    Publication date: August 3, 2023
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20230241175
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: February 28, 2023
    Publication date: August 3, 2023
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20230233649
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: February 27, 2023
    Publication date: July 27, 2023
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20230190877
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: October 11, 2022
    Publication date: June 22, 2023
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-based molecules and methods of use thereof
    Patent number: 11679144
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: May 26, 2022
    Date of Patent: June 20, 2023
    Assignee: Altor Bioscience, LLC.
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • ANTI-CD26 PROTEINS AND USES THEREOF
    Publication number: 20230174666
    Abstract: Provided herein are proteins comprising an anti-CD26 antigen-binding domain. Also provided herein are methods of treating an aging-related disease or an inflammatory disease in a subject that include administering to the subject one of these proteins or a cell expressing one of these proteins.
    Type: Application
    Filed: April 29, 2021
    Publication date: June 8, 2023
    Inventors: Hing C. Wong, Bai Liu, Lin Kong, Xiaoyun Zhu, Catherine Spanoudis
  • IL-15-based fusions to IL-12 and IL-18
    Patent number: 11612645
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Grant
    Filed: August 19, 2022
    Date of Patent: March 28, 2023
    Assignee: Altor Bioscience, LLC
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • IL-15-based fusions to IL-12 and IL-18
    Patent number: 11571470
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: February 7, 2023
    Assignee: Altor Bioscience LLC
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • IL-15-BASED FUSIONS TO IL-12 AND IL-18
    Publication number: 20220387570
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Application
    Filed: August 19, 2022
    Publication date: December 8, 2022
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • IL-15-based molecules and methods of use thereof
    Patent number: 11471511
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: October 18, 2022
    Assignee: Altor Bioscience, LLC
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong