Patents by Inventor Bai-Yu Lee Clemens

Bai-Yu Lee Clemens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pathogen-specific cargo delivery and diagnostic platform based on mesoporous silica nanoparticles
    Patent number: 11045555
    Abstract: In various embodiments nanoparticle drug delivery vehicles are provided that specifically deliver a cargo to a target pathogenic organism. In certain embodiments the drug delivery vehicle comprises a mesoporous silica nanoparticle comprising a plurality of pores and an outer surface through which the pores are disposed; a cargo disposed in the pores; one or more antigens attached to the surface of the nanoparticle; an antibody that specifically binds the antigens and are bound to the antigens, wherein the antibody inhibits diffusion of the cargo out of the pores and permit release of the cargo when the drug delivery vehicle is in the presence of the antigen or a pathogen displaying the antigen.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: June 29, 2021
    Assignee: The Regents of the University of California
    Inventors: Jeffrey I. Zink, Bastian Ruehle, Marcus A. Horwitz, Daniel L. Clemens, Bai-Yu Lee Clemens
  • Multi-drug therapies for tuberculosis treatment
    Patent number: 10576079
    Abstract: The present invention is directed to methods of treating tuberculosis by providing a pharmaceutically effective amount of a combination of drug compounds.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: March 3, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Chih-Ming Ho, Daniel L. Clemens, Bai-Yu Lee Clemens, Marcus Aaron Horwitz, Aleidy Marlene Silva Vite, Theodore Kee, Xianting Ding
  • PATHOGEN-SPECIFIC CARGO DELIVERY AND DIAGNOSTIC PLATFORM BASED ON MESOPOROUS SILICA NANOPARTICLES
    Publication number: 20190321486
    Abstract: In various embodiments nanoparticle drug delivery vehicles are provided that specifically deliver a cargo to a target pathogenic organism. In certain embodiments the drug delivery vehicle comprises a mesoporous silica nanoparticle comprising a plurality of pores and an outer surface through which the pores are disposed; a cargo disposed in the pores; one or more antigens attached to the surface of the nanoparticle; an antibody that specifically binds the antigens and are bound to the antigens, wherein the antibody inhibits diffusion of the cargo out of the pores and permit release of the cargo when the drug delivery vehicle is in the presence of the antigen or a pathogen displaying the antigen.
    Type: Application
    Filed: April 19, 2019
    Publication date: October 24, 2019
    Inventors: Jeffrey I. Zink, Bastian Ruehle, Marcus A. Horwitz, Daniel L. Clemens, Bai-Yu Lee Clemens
  • MULTI-DRUG THERAPIES FOR TUBERCULOSIS TREATMENT
    Publication number: 20190030026
    Abstract: The present invention is directed to methods of treating tuberculosis by providing a pharmaceutically effective amount of a combination of drug compounds.
    Type: Application
    Filed: September 14, 2018
    Publication date: January 31, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Chih-Ming Ho, Daniel L. Clemens, Bai-Yu Lee Clemens, Marcus Aaron Horwitz, Aleidy Marlene Silva Vite, Theodore Kee, Xianting Ding
  • Multi-drug therapies for tuberculosis treatment
    Patent number: 10080749
    Abstract: The present invention is directed to methods of treating tuberculosis by providing a pharmaceutically effective amount of a combination of drug compounds.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: September 25, 2018
    Assignee: The Regents of the University of California
    Inventors: Chih-Ming Ho, Daniel L. Clemens, Bai-Yu Lee Clemens, Marcus Aaron Horwitz, Aleidy Marlene Silva Vite, Theodore Kee, Xianting Ding
  • MULTI-DRUG THERAPIES FOR TUBERCULOSIS TREATMENT
    Publication number: 20170333427
    Abstract: The present invention is directed to methods of treating tuberculosis by providing a pharmaceutically effective amount of a combination of drug compounds.
    Type: Application
    Filed: November 3, 2015
    Publication date: November 23, 2017
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SHANGHAI JIAO TONG UNIVERSITY
    Inventors: Chih-Ming Ho, Daniel L. Clemens, Bai-Yu Lee Clemens, Marcus Aaron Horwitz, Aleidy Marlene Silva Vite, Theodore Kee, Xianting Ding