Abstract: A valve leaflet obstruction repair clip and a repair system thereof include a clamping component and a flow obstruction component. The clamping component and the flow obstruction component are assembled and clamped to fix the incomplete closure between the valve leaflets. The upper clamping arm and the lower clamping arm are engaged together in a natural state, and the upper clamping arm undergoes unilateral movement in an extended state. The present application enables edge-to-edge repair of the valve leaflets and adopts unilateral clamping, effectively preventing the problem of valve leaflet stenosis caused by the implantation of the repair device.

Abstract: A leaflet positioning and fixing clip and a narrow-environment orientation system thereof are provided. The clip includes a fixing element, a lower gripping arm assembly sleeved outside the fixing element, an upper gripping arm assembly sleeved outside the lower gripping arm assembly, a pull rope controlling the upper gripping arm assembly to move, and an occlusive film attached below the lower gripping arm assembly. The upper gripping arm assembly includes an upper central fixing plate and upper gripping arms radially distributed around the upper central fixing plate. The lower gripping arm assembly includes a lower central fixing plate and lower gripping arms. There are at least two upper gripping arms mated with at least two lower gripping arms to form grippers for gripping a tricuspid valve. The occlusive film is stably positioned in a center of the tricuspid valve through the grippers.

Abstract: A leaflet positioning and fixing clip and a narrow-environment orientation system thereof are provided. The clip includes a fixing element, a lower gripping arm assembly sleeved outside the fixing element, an upper gripping arm assembly sleeved outside the lower gripping arm assembly, a pull rope controlling the upper gripping arm assembly to move, and an occlusive film attached below the lower gripping arm assembly. The upper gripping arm assembly includes an upper central fixing plate and upper gripping arms radially distributed around the upper central fixing plate. The lower gripping arm assembly includes a lower central fixing plate and lower gripping arms. There are at least two upper gripping arms mated with at least two lower gripping arms to form grippers for gripping a tricuspid valve. The occlusive film is stably positioned in a center of the tricuspid valve through the grippers . A leaflet positioning and fixing clip and a narrow-environment orientation system thereof are provided.

Abstract: The disclosure relates to microRNAs (miRNAs) for the prophylaxis and/or treatment of neoplasia. The disclosure relates in particular to sequence corresponding to miR2 and the miR-548 family, including precursors, mature forms, fragments, and combinations thereof for the prophylaxis and/or treatment of neoplasias, particularly lung, stomach, and cervical cancer, alone or in combination with additional cancer treatments and therapeutics.