Abstract: The present invention teaches a design of apparatus using which microspheres of customizable uni-sizes may be produced through a greatly simplified process. The apparatus consists a microsphere-forming unit, a microsphere rinsing unit, and a sterile hood that isolate the other two unit within a sterilized cover. The microsphere-forming unit enables the processed of microsphere formation, solidification and collection simultaneously. The sterile hood allow the microsphere producing operation be carried out within a glove box, preventing direct contact of operator with the sterilized materials of the microspheres. The apparatus has also a refrigerator wherein the microsphere collector and final product storage are placed for extracting the solvent of microsphere-forming materials and stabilizing the final product, respectively.