Abstract: A disposable article of manufacture, adapted for use by an infant to provide an analgesic effect, comprises: (a) a dispensing device having a container portion for holding an analgesic liquid and a contiguous nipple-shaped portion designed to be sucked by an infant, for pacifying the infant while at the same time dispensing and administering the analgesic liquid to the infant through at least one opening in the nipple-shaped portion; and (b) a dose of the analgesic liquid, in sterile form, disposed in the container portion and/or the nipple-shaped portion of the dispensing device, the dose having a having a volume in the range of 1 to 10 ml and the analgesic liquid consisting essentially of a water solution of sucrose and having a sucrose concentration in the range of 20 to 60% w/v and (c) a removable article for sealing the opening in the nipple-shaped portion and the dose of analgesic liquid, thereby to prevent entry of bacteria into the analgesic liquid and prevent discharge of the analgesic liquid when