Patents by Inventor Balázs Volk
Balázs Volk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230331727Abstract: Method for the production of formula (I) lumateperone or its acid addition salts so that the enantiomer compound with stereochemistry 6bR,10aS is separated form the cis racemate using resolution and the formula (II) stereoisomer is alkylated with 4-halo-4?-fluoro butyrophenone (X = I, Br, Cl) to produce the formula (I) lumateperone, or optionally its acid addition salt. The object of the invention also relates to the amorphous form of the morphologically uniform p-toluenesulfonic acid salt of lumateperone and to the naphthalene-2-sulfonic acid salt of lumateperone, to the 1:2 stoichiometry salt of lumateperone formed with naphthalene-2-sulfonic acid.Type: ApplicationFiled: February 16, 2023Publication date: October 19, 2023Applicant: EGIS GYOGYSZERGYAR ZRT.Inventors: Gábor BERECZ, Bálint NYULASI, Mátyás MILEN, Gyula SIMIG, András MRAVIK, Gábor NÉMETH, Adrienn KESZTHELYI, Beatrix BALI, Balázs VOLK, László SZLÁVIK, Zoltán VARGA, Daniel ULEJ
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Patent number: 11655251Abstract: Method for the production of formula (I) lumateperone or its acid addition salts so that the enantiomer compound with stereochemistry 6bR,10aS is separated form the cis racemate using resolution and the formula (II) stereoisomer is alkylated with 4-halo-4?-fluoro butyrophenone (X=I, Br, Cl) to produce the formula (I) lumateperone, or optionally its acid addition salt. The object of the invention also relates to the amorphous form of the morphologically uniform p-toluenesulfonic acid salt of lumateperone and to the naphthalene-2-sulfonic acid salt of lumateperone, to the 1:2 stoichiometry salt of lumateperone formed with naphthalene-2-sulfonic acid.Type: GrantFiled: November 27, 2018Date of Patent: May 23, 2023Assignee: EGIS GYOGYSZERGYAR ZRT.Inventors: Gábor Berecz, Bálint Nyulasi, Mátyás Milen, Gyula Simig, András Mravik, Gábor Németh, Adrienn Keszthelyi, Beatrix Bali, Balázs Volk, László Szlávik, Zoltán Varga, Daniel Ulej
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Publication number: 20210070755Abstract: Method for the production of formula (I) lumateperone or its acid addition salts so that the enantiomer compound with stereochemistry 6bR,10aS is separated form the cis racemate using resolution and the formula (II) stereoisomer is alkylated with 4-halo-4?-fluoro butyrophenone (X?I, Br, Cl) to produce the formula (I) lumateperone, or optionally its acid addition salt. The object of the invention also relates to the amorphous form of the morphologically uniform p-toluenesulfonic acid salt of lumateperone and to the naphthalene-2-sulfonic acid salt of lumateperone, to the 1:2 stoichiometry salt of lumateperone formed with naphthalene-2-sulfonic acid.Type: ApplicationFiled: November 27, 2018Publication date: March 11, 2021Applicant: EGIS GYOGYSZERGYAR ZRT.Inventors: Gábor BERECZ, Bálint NYULASI, Mátyás MILEN, Gyula SIMIG, András MRAVIK, Gábor NÉMETH, Adrienn KESZTHELYI, Beatrix BALI, Balázs VOLK, László SZLÁVIK, Zoltán VARGA, Daniel ULEJ
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Publication number: 20200087269Abstract: The present invention relates a new process for the preparation of ozanimod of the formula and acid addition salts, via new intermediates and a new polimop form of ozanimod base.Type: ApplicationFiled: May 18, 2018Publication date: March 19, 2020Applicant: EGIS GYOGYSZERGYAR ZRT.Inventors: Marta PORCS-MAKKAY, Gyula SIMIG, Eniko MOLNAR, Janos PETHO, Balazs VOLK, Laszlo SZLAVIK, Eva SZABO, Judit HALASZ
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Publication number: 20190040037Abstract: The object of the invention relates to a novel group of compounds of general formula 20 that may be used as an intermediate for the production of the pharmaceutical active substance pomalidomide. The object of the invention also relates to a novel, cost-effective, productive method for the production of pomalidomide that can also be implemented on industrial scales via the novel compound of formula 20 according to the invention.Type: ApplicationFiled: January 19, 2017Publication date: February 7, 2019Applicant: EGIS GYOGYSZERGYAR ZRT.Inventors: Balazs VOLK, Katalin KATAINE FADGYAS, Gyula LUKACS, Maria TOTHNE LAURITZ, Andras DANCSO, Imre KIRALY, Laszlo PALOTAI, Robert KORMANY
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Patent number: 10023566Abstract: The invention relates to normal or acidic salts of dasatinib and the hydrate and solvate forms thereof. More specifically the invention concerns: dasatinib cyclamic acid salt, dasatinib cyclamic acid (1:1) salt Form I, dasatinib cyclamic acid (1:1) salt Form II, dasatinib hydrogen bromide (1:2) salt, dasatinib methane sulfonic acid (1:2) salt, dasatinib p-toluenesulfonic acid (1:1) dihydrate salt, anhydrous dasatinib p-toluenesulfonic acid (1:1) salt Form I, anhydrous dasatinib p-toluenesulfonic acid (1:1) salt Form II, dasatinib p-toluenesulfonic acid (1:1) salt methanol solvate. Moreover the invention relates process for preparing dasatinib salts, pharmaceutical compositions comprising thereof and the use of dasatinib salts the treatment of cancer.Type: GrantFiled: May 26, 2015Date of Patent: July 17, 2018Assignee: EGIS GYOGYSZERGYAR ZRTInventors: Ede Laszlo Marvanyos, Attila Virag, Tamas Gregor, Balazs Volk, Maria Tothne Lauritz, Laszlo Pongo, Balazs Peregi, Gyula Lukacs, Zoltan Varga, Andras Dancso
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Patent number: 9926332Abstract: Compounds of formula (I) having a selective dual action on the central GABAergic system, and a process for their preparation and to pharmaceutical compositions containing them.Type: GrantFiled: January 20, 2015Date of Patent: March 27, 2018Assignee: Egis Gyogyszergyar Zrt.Inventors: Agnes Kenez, Ferenc Bertha, Jozsef Barkoczy, Ferenc Antoni, Istvan Gacsalyi, Balazs Mihalik, Gabor Gigler, Krisztina Moricz, Gabor Nemeth, Agnes Angyalne Pataki, Gabor Laszlo Kapus, Adrienn Palvolgyi, Istvan Ling, Janos Petho, Gyula Simig, Balazs Volk, Lax Gyorgyi Kovanyine, Andras Dancso
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Patent number: 9822086Abstract: The invention relates to an improved process for the preparation of pharmaceutical active ingredients and also to high purity salts and pharmaceutical compositions prepared by said process. More particularly the invention relates to an economical process for the preparation of the compound having the international non-proprietary name (INN) vortioxetine and the chemical nomenclature 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine. Vortioxetine corresponds to the following Formula Still more particularly the invention relates to the preparation of high purity vortioxetine L-(+)-mandelate salt of the Formula IX, the conversion of this salt into other highly pure salts and also to the formulation of said salts.Type: GrantFiled: January 30, 2015Date of Patent: November 21, 2017Assignee: EGIS GYOGYSZERGYAR ZRT.Inventors: Istvan Ling, Gyorgy Jeges, Gyorgyi Kovanyine Lax, Balazs Volk, Peter Gregor, Jeno Peter Seres, Andras Dancso, Zoltan Varga, Eva Szabo
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Publication number: 20170183334Abstract: The invention relates to normal or acidic salts of dasatinib and the hydrate and solvate forms thereof. More specifically the invention concerns: dasatinib cyclamic acid salt, dasatinib cyclamic acid (1:1) salt Form I, dasatinib cyclamic acid (1:1) salt Form II, dasatinib hydrogen bromide (1:2) salt, dasatinib methane sulfonic acid (1:2) salt, dasatinib p-toluenesulfonic acid (1:1) dihydrate salt, anhydrous dasatinib p-toluenesulfonic acid (1:1) salt Form I, anhydrous dasatinib p-toluenesulfonic acid (1:1) salt Form II, dasatinib p-toluenesulfonic acid (1:1) salt methanol solvate. Moreover the invention relates process for preparing dasatinib salts, pharmaceutical compositions comprising thereof and the use of dasatinib salts the treatment of cancer.Type: ApplicationFiled: May 26, 2015Publication date: June 29, 2017Applicant: EGIS GYOGYSZERGYAR ZRTInventors: Ede Laszlo MARVANYOS, Attila VIRAG, Tamas GREGOR, Balazs VOLK, Maria TOTHNE LAURITZ, Laszlo PONGO, Balazs PEREGI, Gyula LUKACS, Zoltan VARGA, Andras DANCSO
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Publication number: 20170114034Abstract: The invention relates to an improved process for the preparation of pharmaceutical active ingredients and also to high purity salts and pharmaceutical compositions prepared by said process. More particularly the invention relates to an economical process for the preparation of the compound having the international non-proprietary name (INN) vortioxetine and the chemical nomenclature 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine. Vortioxetine corresponds to the following Formula Still more particularly the invention relates to the preparation of high purity vortioxetine L-(+)-mandelate salt of the Formula IX, the conversion of this salt into other highly pure salts and also to the formulation of said salts.Type: ApplicationFiled: January 30, 2015Publication date: April 27, 2017Applicant: Egis Gyogyszergyar Zrt.Inventors: Istvan LING, Gyorgy JEGES, Gyorgyi KOVANYINE LAX, Balazs VOLK, Peter GREGOR, Jeno Peter SERES, Andras DANCSO, Zoltan VARGA, Eva SZABO
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Patent number: 9556163Abstract: The invention relates to a process for the preparation of 5-chloro-N-({(5-S)-2-oxo3-[4-(3-oxo-morj)holine-4-yl)-phenyl]-1,3-oxazolidine-5-yl}-methyl) thiophen-2-carboxamide having the INN rivaroxaban. The invention also relates to intermediates formed in the above process.Type: GrantFiled: May 4, 2012Date of Patent: January 31, 2017Assignee: EGIS Gyogyszergyar Nyilvanosan Mukodo ReszvenytarsasagInventors: Eva Sipos, Gyorgyi Kovanyine Lax, Balazs Havasi, Balazs Volk, Gyorgy Krasznai, Gyorgy Ruzsics, Jozsef Barkoczy, Maria Tothne Lauritz, Gyula Lukacs, Andras Boza, Laszlo Jozsef Hegedus, Maria Julia Taborine Toth, Eva Pecsi
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Publication number: 20170002020Abstract: Compounds of formula (I) having a selective dual action on the central GABAergic system, and a process for their preparation and to pharmaceutical compositions containing them.Type: ApplicationFiled: January 20, 2015Publication date: January 5, 2017Applicant: Egis Gyogyszergyar Zrt.Inventors: Agnes KENEZ, Ferenc BERTHA, Jozsef BARKOCZY, Ferenc ANTONI, Istvan GACSALYI, Balazs MIHALIK, Gabor GIGLER, Krisztina MORICZ, Gabor NEMETH, Agnes ANGYALNE PATAKI, Gabor Laszlo KAPUS, Adrienn PALVOLGYI, Istvan LING, Janos PETHO, Gyula SIMIG, Balazs VOLK, Lax Gyorgyi KOVANYINE, Andras DANCSO
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Patent number: 9321733Abstract: The present invention is related to crystalline forms of rosuvastatin zinc (2:1) salt. The polymorphs are suitable for use as pharmaceutically active ingredients in the treatment of the diseases of the lipid metabolism including hypercholesterolemia, hyperlipidemia, dyslipidemia or atherosclerosis.Type: GrantFiled: November 16, 2011Date of Patent: April 26, 2016Assignee: EGIS Gyogyszergyar Nyilvanosan Mukodo ReszvenytarsasagInventors: Imre Markovits, Ferenc Jurak, Gyorgyi Kovanyine Lax, Csaba Hamori, Balazs Havasi, Eva Sipos, Balazs Volk, Zsolt Runge, Krisztina Fodorne Kocsmar, Gyula Lukacs, Katalin Kataine Fadgyas, Monika Mezovari
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Patent number: 9260421Abstract: The present invention relates to a process for the preparation of dabigatran etexilate of the formula or pharmaceutically accepted salts thereof.Type: GrantFiled: May 10, 2012Date of Patent: February 16, 2016Assignee: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAGInventors: Imre Kiraly, Tibor Szabo, Gyula Simig, Balazs Volk, Laszlo Szlavik, Jozsef Barkoczy, Gyorgy Ruzsics, Gyula Lukacs, Laszlo Pongo, Andras Boza, Maria Tothne Lauritz, Maria Kovacs
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Patent number: 9169265Abstract: The object of the present invention is a process for preparing the 2-acetoxi-5-(2-fluor-?-cyclopropyl-carbonyl-benzyl)-4,5,6,7-tetrahydro-4H-thieno[3,2-c]pyridine (prasugrel) of the formula (I). The process starts from crystalline 5-trityl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine of the formula (VI). Further objects of the present invention are two novel crystalline forms of 5-trityl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine of the formula (VI) and the use thereof for preparing the compound of the formula (V) and process preparing thereof.Type: GrantFiled: December 21, 2010Date of Patent: October 27, 2015Assignee: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAGInventors: Márta Porcs-Makkay, Balázs Volk, Tamás Gregor, József Barkóczy, Tibor Mezei, Judit Broda, Bálint Nyulasi, György Ruzsics, Enikö Molnár, József Debreczeni, Kálmán Nagy, Angéla Pandur, Zsuzsanna Szent-Királlyi
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Patent number: 9133132Abstract: The present invention is related to intermediates useful in the preparation of pharmaceutically acceptable salts of (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-(3R,5S)-dihydroxy-hept-6-enoic acid and polymorphs of said intermediates, methods for preparation thereof and use thereof.Type: GrantFiled: November 29, 2011Date of Patent: September 15, 2015Assignee: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAGInventors: Gyorgyi Kovanyine Lax, Gyula Simig, Balazs Volk, Ferenc Lorant Bartha, Gyorgy Krasznai, Gyorgy Ruzsics, Eva Sipos, Kalman Nagy, Gyorgy Morovjan, Jozsef Barkoczy, Adrienn Keszthelyi, Janos Imre, Gabor Bagyinszki
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Patent number: 9040696Abstract: The present invention is related to methods for the preparation of pharmaceutically acceptable salts of (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-(3R,5S,6E)-dihydroxy-hept-6-enoic acid, intermediates thereof and methods for producing said intermediates.Type: GrantFiled: November 29, 2011Date of Patent: May 26, 2015Assignee: EGIS Gyogyszergyar Nyilvanosan Mukodo ReszvenytarsasagInventors: Marta Porcs-Makkay, Ferenc Lorant Bartha, Gyorgy Krasznai, Balazs Volk, Gyorgy Ruzsics, Laszlo Pongo, Gyula Lukacs, Tibor Szabo, Jozsef Barkoczy, Jozsef Debreczeni, Adrienn Keszthelyi, Angela Pandur, Eniko Molnar, Matyas Milen, Maria Tothne Lauritz
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Patent number: 9023838Abstract: The present invention relates to crystalline Form I rosuvastatin zinc (2:1) salt, method of preparation thereof and use thereof as pharmaceutically active ingredient for the treatment of diseases related to lipid metabolism including hyperlipoproteinemia, hypercholesteremia, dyslipidemia and atherosclerosis.Type: GrantFiled: July 24, 2009Date of Patent: May 5, 2015Assignee: Egis Gyogyszergyar Nyilvanosan MuekoedoeInventors: Ferenc Bartha, Gyoergyi Kovanyine Lax, Balazs Volk, Jozsef Barkoczy, Gyoergy Morovjan, Gyoergy Krasznai, Kalman Nagy, Gyula Simig, Gyoergy Ruzsics, Gyoergy Clementis, Imre Kapui, Peter Slegel, Adrienn Keszthelyi, Zsuzsanna Szent-Kirallyi, Valeria Hoffmanne Fekete, Janos Imre
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Patent number: 8877799Abstract: The present invention relates to the use of novel vildagliptin complexes for the manufacture of high purity vildagliptin of Formula I and/or pharmaceutical acceptable salts thereof. Further objects of the present invention are pharmaceutically acceptable complexes of vildagliptin and/or amorphous and crystalline forms, anhydrous forms, amorphous and crystalline hydrates, amorphous and crystalline solvates of the complexes and a process for the preparation thereof. Another object of the present invention is the high purity vildagliptin and pharmaceutically acceptable salts thereof prepared form the vildagliptin complexes of the present invention, a process for the preparation thereof and pharmaceutical compositions containing vildagliptin base, pharmaceutically acceptable salts and/or complexes and use thereof for the treatment of type 2 diabetes (NIDDM). The present invention provides pharmaceutically advantageous high purity vildagliptin complexes.Type: GrantFiled: October 7, 2010Date of Patent: November 4, 2014Assignee: Egis Gyogyszergynar Nyilvanosan Muekoedoe ReszvenytarsasagInventors: Andras Mravik, Imre Koehegyi, Laszlo Pongo, Balazs Volk, Gabor Nemeth, Jozsef Barkoczy, Kalman Nagy, Gyoergy Ruzsics, Judit Broda, Andras Dancso, Adrienn Keszthelyi, Jozsef Debreczeni
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Publication number: 20140155614Abstract: The present invention relates to a process for the preparation of dabigatran etexilate of the formula or pharmaceutically accepted salts thereof.Type: ApplicationFiled: May 10, 2012Publication date: June 5, 2014Applicant: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAGInventors: Imre Kiraly, Tibor Szabo, Gyula Simig, Balazs Volk, Laszlo Szlavik, Jozsef Barkoczy, Gyorgy Ruzsics, Gyula Lukacs, Laszlo Pongo, Andras Boza, Maria Tothne Lauritz, Maria Kovacs