Patents by Inventor Bala S. Manian

Bala S. Manian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11028168
    Abstract: The present disclosure relates to methods for treatment and prevention of disease conditions mediated by T-helper 17 (Th17) and/or T-helper 1 (Th1) T lymphocytes (T cells). In particular, the present disclosure relates to use of anti-CD6 antibody for treatment of disease conditions mediated by auto-reactive Th17 and Th1 T lymphocytes. The methods of the present disclosure further have utility in methods for modulating an immune response by suppressing production of the cytokine IL-23R, thereby decreasing inflammation mediated by Th17 cells.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: June 8, 2021
    Assignee: BIOCON LIMITED
    Inventors: Pradip Nair, Ramakrishnan Melarkode, Bala S. Manian, Abhijit Barve, Usha Bughani, Jose Enrique Montero Casimiro
  • Patent number: 10976258
    Abstract: The invention relates to a porous planar cell capture system for use in determining the presence and/or amount of cells, for example, viable cells, in a liquid sample, and to methods of using such a cell capture system. The cell capture system contains a fluid permeable, planar membrane adopted to retain cells thereon, a fluid permeable support member that supports the membrane, and an optional register associated with the membrane.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: April 13, 2021
    Assignees: Charles River Laboratories, Inc., ReaMetrix Inc.
    Inventors: Norman R. Wainwright, Bala S. Manian, Eric Stimpson, Brian J. Kolonia, Robert K. Kolonia
  • Publication number: 20200183140
    Abstract: Filter membranes and the like carrying fluorescent targets suspected of being bioburden are tested by mounting the membranes on a sample holder within a cabinet for bioburden verification and discrimination from false positives. Fluorescence is excited by a fluorescence excitation module having a first optical axis perpendicular to the sample, with three dimension locations of fluorescent targets that are probable bioburden stored for use by a microscope imaging module having a second optical axis parallel to the first optical axis, with dual wavelength illumination for autofocus and then for stimulating fluorescence without photo bleaching of the targets. The probable bioburden targets are moved for inspection and identification in the microscope imaging module as bioburden or not by sharing a common sample holder in the cabinet.
    Type: Application
    Filed: December 11, 2019
    Publication date: June 11, 2020
    Applicant: ReaMetrix, Inc.
    Inventor: Bala S. Manian
  • Publication number: 20190345247
    Abstract: The present disclosure relates to methods for treatment and prevention of disease conditions mediated by T-helper 17 (Th17) and/or T-helper 1 (Th1) T lymphocytes (T cells). In particular, the present disclosure relates to use of anti-CD6 antibody for treatment of disease conditions mediated by auto-reactive Th17 and Th1 T lymphocytes. The methods of the present disclosure further have utility in methods for modulating an immune response by suppressing production of the cytokine IL-23R, thereby decreasing inflammation mediated by Th17 cells.
    Type: Application
    Filed: December 10, 2018
    Publication date: November 14, 2019
    Inventors: PRADIP NAIR, RAMAKRISHNAN MELARKODE, BALA S. MANIAN, ABHIJIT BARVE, USHA BUGHANI, JOSE ENRIQUE MONTERO CASIMIRO
  • Publication number: 20190187056
    Abstract: The invention relates to a porous planar cell capture system for use in determining the presence and/or amount of cells, for example, viable cells, in a liquid sample, and to methods of using such a cell capture system. The cell capture system contains a fluid permeable, planar membrane adopted to retain cells thereon, a fluid permeable support member that supports the membrane, and an optional register associated with the membrane.
    Type: Application
    Filed: February 25, 2019
    Publication date: June 20, 2019
    Inventors: Norman R. Wainwright, Bala S. Manian, Eric Stimpson, Brian J. Kolonia, Robert K. Kolonia
  • Patent number: 10324036
    Abstract: The invention relates to a porous planar cell capture system for use in determining the presence and/or amount of cells, for example, viable cells, in a liquid sample, and to methods of using such a cell capture system. The cell capture system contains a fluid permeable, planar membrane adopted to retain cells thereon, a fluid permeable support member that supports the membrane, and an optional register associated with the membrane.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: June 18, 2019
    Assignees: Charles River Laboratories, Inc., ReaMetrix Inc.
    Inventors: Norman R. Wainwright, Bala S. Manian, Eric Stimpson, Brian J. Kolonia, Robert K. Kolonia
  • Publication number: 20190086324
    Abstract: Provided herein are systems, devices and methods for performing multianalyte detection in a biological sample, such as a human blood sample. Multiwell plates useful for performing multianalyte detection are also provided. The systems, devices and methods provided herein relate to the field of direct-to-consumer diagnostics (DTC diagnostics) and are useful, e.g., for facilitating consumer access to consumer healthcare and consumer wellness information. Other uses of the systems, devices and methods provided herein relate to the fields of medical research and drug discovery.
    Type: Application
    Filed: March 23, 2017
    Publication date: March 21, 2019
    Inventors: Dena C. Marrinucci, Randal L. Erman, Bala S. Manian
  • Patent number: 10189899
    Abstract: The present disclosure relates to methods for treatment and prevention of disease conditions mediated by T-helper 17 (Th17) and/or T-helper 1 (Th1) T lymphocytes (T cells). In particular, the present disclosure relates to use of anti-CD6 antibody for treatment of disease conditions mediated by auto-reactive Th17 and Th1 T lymphocytes. The methods of the present disclosure further have utility in methods for modulating an immune response by suppressing production of the cytokine IL-23R, thereby decreasing inflammation mediated by Th17 cells.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: January 29, 2019
    Assignee: BIOCON LIMITED
    Inventors: Pradip Nair, Ramakrishnan Melarkode, Bala S. Manian, Abhijit Barve, Usha Bughani, Jose Enrique Montero Casimiro
  • Publication number: 20180120231
    Abstract: The invention relates to a method for determining the presence and/or amount of viable cells in a liquid sample. The method includes (a) labeling with a fluorescent label viable cells remaining on a porous membrane after passing the liquid sample therethrough, (b) scanning a portion of the porous membrane by rotating the porous membrane relative to a detection system, and (c) determining the presence and/or quantity of viable cells captured by the membrane.
    Type: Application
    Filed: June 2, 2017
    Publication date: May 3, 2018
    Inventors: Norman R. Wainwright, Bala S. Manian, Eric Stimpson, Brian J. Kolonia, Robert K. Kolonia
  • Patent number: 9709500
    Abstract: The invention relates to a method for determining the presence and/or amount of viable cells in a liquid sample. The method includes (a) labeling with a fluorescent label viable cells remaining on a porous membrane after passing the liquid sample therethrough, (b) scanning a portion of the porous membrane by rotating the porous membrane relative to a detection system, and (c) determining the presence and/or quantity of viable cells captured by the membrane.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: July 18, 2017
    Assignees: Charles River Laboratories, Inc., ReaMetrix Inc.
    Inventors: Norman R. Wainwright, Bala S. Manian, Eric Stimpson, Brian J. Kolonia, Robert K. Kolonia
  • Patent number: 9671345
    Abstract: A method and apparatus for three dimensional fluorescent analysis of a target in a liquid sample having fluorescent analyte as a target substance or fluorescent label on the target substance. A rotating carousel carries liquid samples beneath a beam having a beam spot at a horizontal plane of the sample. The carousel advances slowly a linear direction during rotation so that a pattern of overlapping spiral scans provide R-theta two-dimensional samples of the entire plane to identify locations of volumes of interest where fluorescence is measurably higher than background. These locations are probed in the depthwise direction to find locations of fluorescent analyte in three dimensions. Light from the analyte or fluorescent label is detected and processed to characterize the target by color, size or other morphology.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: June 6, 2017
    Assignee: Reametrix, Inc.
    Inventor: Bala S. Manian
  • Patent number: 9669406
    Abstract: In one aspect, the invention provides a sample assembly to be used in a fluorescent measurement device. The sample assembly comprises a sample carrier, a sample holder that comprises at least one receptacle and a movable platform. The sample carrier is shaped in such a way that it can be secured into the receptacle by a suitable locking means. The sample holder is held in place on the movable platform through any suitable means, such as for example, a magnetic means. The movable platform is capable of moving in a linear trajectory, an arcuate trajectory and combinations thereof. The movement of the movable platform and hence, the entire sample assembly is effected by at least one stepper motor.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: June 6, 2017
    Assignee: Reametrix, Inc.
    Inventors: Bala S. Manian, Pramod Kummaya
  • Patent number: 9523640
    Abstract: The invention provides a method and device for fluorescent measurement of a volume of liquid sample in a sample carrier. The method includes impinging an incident beam having an excitation wavelength and a focus diameter on the sample in a two dimensional scan, such as an R-theta scan or a spiral scan, with a laser spot that identifies a volume of interest where higher levels of fluorescence exist. The laser spot is displaced relative to the sample volume in three dimensional space. The laser spot is translated in the depth direction of the volume of interest to detect one or more emitted fluorescence signals. A depth profile and a thickness of the sample carrier obtained from the one or more emitted fluorescence signals, are used for measuring normalized bulk fluorescence.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: December 20, 2016
    Assignee: Reametrix, Inc.
    Inventor: Bala S. Manian
  • Patent number: 9446411
    Abstract: A sample presentation apparatus comprises a round support movable in an optical assembly and having a flange region and an elevated gear shaped region having indexing gear cogs at intermediate radius locations of the support; a sample carrier slide holder removably supported on and movable with the support, the slide holder having at least one arm extending radially from a central hub of the sample carrier slide holder and being aligned between a first pair of indexing gear cogs; and at least one sample carrier slide removably supported on the support and aligned by the first pair of indexing gear cogs. In another embodiment of the invention, a self-aligning movable platform and support apparatus in an optical assembly comprises coarse and fine alignment mechanisms.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: September 20, 2016
    Assignee: REAMETRIX, INC.
    Inventors: Bala S. Manian, Pramod Kummaya
  • Publication number: 20160152705
    Abstract: The present disclosure relates to methods for treatment and prevention of disease conditions mediated by T-helper 17 (Th17) and/or T-helper 1 (Th1) T lymphocytes (T cells). In particular, the present disclosure relates to use of anti-CD6 antibody for treatment of disease conditions mediated by auto-reactive Th17 and Th1 T lymphocytes. The methods of the present disclosure further have utility in methods for modulating an immune response by suppressing production of the cytokine IL-23R, thereby decreasing inflammation mediated by Th17 cells.
    Type: Application
    Filed: July 23, 2014
    Publication date: June 2, 2016
    Inventors: PRADIP NAIR, RAMAKRISHNAN MELARKODE, BALA S. MANIAN, ABHIJIT BARVE, USHA BUGHANI, JOSE ENRIQUE MONTERO CASIMIRO
  • Patent number: D719666
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: December 16, 2014
    Assignee: Reametrix, Inc.
    Inventor: Bala S. Manian
  • Patent number: D719667
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: December 16, 2014
    Assignee: Reametrix, Inc.
    Inventor: Bala S. Manian
  • Patent number: D726929
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: April 14, 2015
    Assignees: Charles River Laboratories, Inc., ReaMetrix, Inc.
    Inventors: Norman R. Wainwright, Bala S. Manian, Eric Stimpson, Brian J. Kolonia, Robert K. Kolonia
  • Cup
    Patent number: D728816
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 5, 2015
    Assignees: Charles River Laboratories, Inc., ReaMetrix, Inc.
    Inventors: Norman R. Wainwright, Bala S. Manian, Eric Stimpson, Brian J. Kolonia, Robert K. Kolonia
  • Patent number: D776296
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: January 10, 2017
    Assignee: Charles River Laboratories, Inc.
    Inventors: Norman R. Wainwright, Dana M. Nutter, Eric Stimpson, Al Fuchs, Thomas Preidel, Bala S. Manian