Patents by Inventor Balaji M. Rao

Balaji M. Rao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant interleukin-2 (IL-2) polypeptides
    Patent number: 8349311
    Abstract: The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2R?). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2? using yeast surface display to generate mutants with increased affinity for IL-2R?.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: January 8, 2013
    Assignee: Massachusetts Institute of Technology
    Inventors: Karl Dane Wittrup, Balaji M. Rao, Douglas A. Lauffenburger
  • MUTANT INTERLEUKIN-2 (IL-2) POLYPEPTIDES
    Publication number: 20110306752
    Abstract: The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2R?). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2? using yeast surface display to generate mutants with increased affinity for IL-2R?.
    Type: Application
    Filed: April 15, 2011
    Publication date: December 15, 2011
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: KARL DANE WITTRUP, BALAJI M. RAO, DOUGLAS A. LAUFFENBURGER
  • Mutant interleukin-2 (IL-2) polypeptides
    Patent number: 7951360
    Abstract: The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2R?). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2? using yeast surface display to generate mutants with increased affinity for IL-2R?.
    Type: Grant
    Filed: August 4, 2009
    Date of Patent: May 31, 2011
    Assignee: Massachusetts Institute of Technology
    Inventors: K. Dane Wittrup, Balaji M. Rao, Douglas A. Lauffenburger
  • Mutant Interleukin-2 (IL-2) Polypeptides
    Publication number: 20100036097
    Abstract: The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2R?). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2? using yeast surface display to generate mutants with increased affinity for IL-2R?.
    Type: Application
    Filed: August 4, 2009
    Publication date: February 11, 2010
    Inventors: K. Dane Wittrup, Balaji M. Rao, Douglas A. Lauffenburger
  • Mutant interleukin-2 (IL-2) polypeptides
    Patent number: 7569215
    Abstract: The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2R?). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2? using yeast surface display to generate mutants with increased affinity for IL-2R?.
    Type: Grant
    Filed: July 19, 2004
    Date of Patent: August 4, 2009
    Assignee: Massachusetts Institute of Technology
    Inventors: K. Dane Wittrup, Balaji M. Rao, Douglas A. Lauffenburger