Abstract: One technique includes receiving, in a first network, a multi-destination packet from a second network, and determining, based on the multi-destination packet, a first multi-destination tree in the first network for forwarding the multi-destination packet. In response to determining that the first multi-destination tree is not rooted on the network device, a second multi-destination tree in the first network is determined, and the multi-destination packet is transmitted using the second multi-destination tree. Another technique includes, upon detecting a first network device joining a network, sending a first indication to a second network device that the first network device is in a state for an amount of time. After the amount of time has elapsed, a second indication that the first network device has exited the state is sent to the second network device. A topology of the network is updated after the first network device has exited the state.

Abstract: Compositions and methods are provided for rapid and efficient production of antibodies in vitro as well as in vivo, which may be used to neutralize antigens. More specifically, the present invention relates to scaffolds comprised of amphiphilic multiblock copolymers that can form micelles based on nonionic or amphiphilic core blocks as well as ionic blocks, and with an antigen and methods of crosslinking B cell receptors to specifically produce antibodies against the antigen in vitro as well as in vivo in a more efficient method than other available monoclonal antibody production method.

Abstract: Provided are aggregate alpha-synuclein specific antibodies as well as fragments, derivatives, and variants thereof as well as method related thereto for the early diagnostic and treatment of Parkinson's Disease and other Lewy body- and Lewy neurite-based diseases. Assays, kits, systems, and nanoparticle encapsulated compositions related to the antibodies or fragments, derivatives, and variants thereof are also disclosed.

Abstract: Immunogenic compositions and methods of using them include a biodegradable or bioerodible polyanhydride nanoparticle comprising 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG) and 1,6-bis(p-carboxyphenoxy)hexane (CPH) copolymers, an immunogenic protein of an Influenza Virus and an adjuvant entrapped within an interior of the nanoparticle, and an excipient. The immunogenic composition may be administered to a subject to confer both local and systemic immunity to the Influenza Virus.

Abstract: Provided are aggregate alpha-synuclein specific antibodies as well as fragments, derivatives, and variants thereof as well as method related thereto for the early diagnostic and treatment of Parkinson's Disease and other Lewy body- and Lewy neurite-based diseases. Assays, kits, systems, and nanoparticle encapsulated compositions related to the antibodies or fragments, derivatives, and variants thereof are also disclosed.

Abstract: Immunogenic compositions and methods of using them include a biodegradable or bioerodible polyanhydride nanoparticle comprising 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG) and 1,6-bis(p-carboxyphenoxy)hexane (CPH) copolymers, an immunogenic protein of an Influenza Virus and an adjuvant entrapped within an interior of the nanoparticle, and an excipient. The immunogenic composition may be administered to a subject to confer both local and systemic immunity to the Influenza Virus.

Abstract: This document provides vaccine delivery devices and methods for vaccinating an animal (e.g., a mammal). For example, vaccine delivery devices that include a container having one or more openings, a vaccine depot located within the container, and a diffusion barrier located within the container in a manner such that material (e.g., an antigenic vaccine component) within the vaccine depot must pass through the diffusion barrier before reaching one of the openings are provided.

Abstract: A cloud services brokerage platform system includes a virtual data center (VDC) and an architecture management interface. The virtual data center (VDC) includes a plurality of resource groups. Each one of the resource groups includes one or more VDC resources. Each one of the VDC resources is associated with a respective set of resource group specification parameters. The architecture management interface enables an architectural layout of the one or more VDC resources to be displayed. The architectural layout includes a visual depiction of the one or more VDC resources of each one of the resource groups. An arrangement of the visual depiction is dependent upon the respective set of resource group specification parameters.

Abstract: Implementation of cross provider security in accordance with the disclosures made herein enables users of a system (e.g., a cloud services brokerage platform) in a cloud environment provides for system-managed provisioning and management of keys to cloud resources thereby allowing the user to manage data security and enable secured access to their cloud resources. To this end, cross provider security management functionality in accordance with the disclosures made herein can include provisioning system-generated keys across different regions in a provider, provisioning cloud brokerage system-generated keys across different providers; and associating (i.e., managing) the keys from the system to a hardware security module. The keys can be managed by/though a variety of different resources (e.g., brokering system, VDC, user group concepts, etc).

Abstract: A cloud services brokerage platform system includes a virtual data center (VDC) and an architecture management interface. The virtual data center (VDC) includes a plurality of resource groups. Each one of the resource groups includes one or more VDC resources. Each one of the VDC resources is associated with a respective set of resource group specification parameters. The architecture management interface enables an architectural layout of the one or more VDC resources to be displayed. The architectural layout includes a visual depiction of the one or more VDC resources of each one of the resource groups. An arrangement of the visual depiction is dependent upon the respective set of resource group specification parameters.

Abstract: A cloud services brokerage platform system includes a virtual data center (VDC) and an architecture management interface. The virtual data center (VDC) includes a plurality of resource groups. Each one of the resource groups includes one or more VDC resources. Each one of the VDC resources is associated with a respective set of resource group specification parameters. The architecture management interface enables an architectural layout of the one or more VDC resources to be displayed. The architectural layout includes a visual depiction of the one or more VDC resources of each one of the resource groups. An arrangement of the visual depiction is dependent upon the respective set of resource group specification parameters.

Abstract: A computer program product is embodied on a non-transitory computer readable medium. The computer program product comprises computer code to display a plurality of first indicia presented in a list, where each first indicia indicates a software product, and computer code to display a second indicia associated with a highlighted one of the first indicia. The second indicia comprises information about the software product indicated by the highlighted first indicia. The computer program product additionally comprises computer code to display a third indicia associated with the highlighted first indicia and indicate the availability of a software update for the software product indicated by the highlighted first indicia, and computer code to display a fourth indicia associated with the highlighted first indicia. The fourth indicia facilitates the retrieval of the software update.

Abstract: This document provides vaccine delivery devices and methods for vaccinating an animal (e.g., a mammal). For example, vaccine delivery devices that include a container having one or more openings, a vaccine depot located within the container, and a diffusion barrier located within the container in a manner such that material (e.g., an antigenic vaccine component) within the vaccine depot must pass through the diffusion barrier before reaching one of the openings are provided.

Abstract: A non-transitory computer-readable storage medium has tangibly embodied thereon and accessible therefrom instructions interpretable by at least one data processing device. The instructions are configured for causing the at least one data processing device to perform a method comprising creating a resource group for providing cloud services, receiving a request to increase a quantity of the virtual machines of the resource group; and instantiating one or more additional virtual machines within the resource group in response to receiving the request. The resource group includes one or more virtual machines that all have virtual machine specifications of a particular configuration. Instantiating the one or more additional virtual machines includes providing each one of the one or more additional virtual machines with virtual machine specifications of the particular configuration.

Abstract: Filarial parasites Brugia, Wuchereria, Loa Loa and Onchocerca cause over 20 million infections worldwide and pose a significant social and economic burden in endemic areas. The invention provides compositions and methods to treat parasitic infections in animals and plants, and to kill and inhibit the replication of parasites in infected hosts. The methods can include administering to a host in need of treatment an effective antiparasitic amount of a composition comprising biodegradable polyanhydride microparticles or nanoparticles that encapsulate antiparasitic agents, optionally in combination with antibacterial agents. Through co-encapsulation of antiparasitic and antibacterial agents into the particles, the invention provides the ability to effectively kill parasitic helminthes, worms, and flukes, with up to a 40-fold reduction in the amount of drug used.

Abstract: A pricing rule is created for governing a manner in which pricing of cloud services is adjusted. The pricing rule includes pricing rule configuration information defining an outcome of the pricing rule when applied to cloud service prices and a pricing rule context defining a boundary within which the pricing rule must be implemented to thereby cause the pricing rule to be applied to the cloud service prices. The pricing rule configuration information can specify a pricing adjustment mode, a type of price upon which the pricing rule is to be applied, an entity to which the outcome of pricing rule is to be allocated, and a category of charge upon which the pricing rule is to be applied. The pricing rule context can include a context basis and one or more context basis selections.

Abstract: Implementation of cross provider security in accordance with the disclosures made herein enables users of a system (e.g., a cloud services brokerage platform) in a cloud environment provides for system-managed provisioning and management of keys to cloud resources thereby allowing the user to manage data security and enable secured access to their cloud resources. To this end, cross provider security management functionality in accordance with the disclosures made herein can include provisioning system-generated keys across different regions in a provider, provisioning cloud brokerage system-generated keys across different providers; and associating (i.e., managing) the keys from the system to a hardware security module. The keys can be managed by/though a variety of different resources (e.g., brokering system, VDC, user group concepts, etc).

Abstract: The invention provides compositions and methods to treat microbial infections in animals, to inhibit the replication of microbes in infected cells, and to kill pathogens in infected cells. The methods can include administering to an animal in need of such treatment an effective antimicrobial amount of a composition comprising polyanhydride microparticles or nanoparticles that encapsulate a plurality of antimicrobial agents. The polyanhydride microparticles or nanoparticles can be, for example, copolymers of sebacic anhydride (SA) and 1,6-bis-(p-carboxyphenoxy)hexane (CPH) anhydride, copolymers of 1,8-bis(carboxyphenoxy)-3,6-dioxaoctane (CPTEG) anhydrides and 1,6-bis-(p-carboxyphenoxy)hexane (CPH) anhydride, or various combinations thereof.

Abstract: A non-transitory computer-readable storage medium has tangibly embodied thereon and accessible therefrom instructions interpretable by at least one data processing device. The instructions are configured for causing the at least one data processing device to perform a method comprising creating a resource group for providing cloud services, receiving a request to increase a quantity of the virtual machines of the resource group; and instantiating one or more additional virtual machines within the resource group in response to receiving the request. The resource group includes one or more virtual machines that all have virtual machine specifications of a particular configuration. Instantiating the one or more additional virtual machines includes providing each one of the one or more additional virtual machines with virtual machine specifications of the particular configuration.

Abstract: A non-transitory computer-readable storage medium has tangibly embodied thereon and accessible therefrom instructions interpretable by at least one data processing device. The instructions are configured for causing the at least one data processing device to perform a method for enabling a user thereof to select one or more cloud service providers that offer cloud service resources fulfilling cloud service resource requirements of a cloud service solution, to procure the cloud service resources from the one or more cloud service providers and to provision the cloud service resources in accordance with the service resource requirements of the cloud service solution.