Patents by Inventor Balakumar Thangaraj

Balakumar Thangaraj has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for purifying proteins
    Patent number: 11952399
    Abstract: The invention pertains to methods of purifying fusion proteins, in particular TNFR:Fc fusion proteins. Methods disclosed herein can be used to produce highly pure TNFR:Fc fusion proteins (e.g., etanercept) having a biological activity by removing hard to separate product related impurities such as clipped and/or mis-fold/aggregated TNFR:Fc fusion proteins.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: April 9, 2024
    Assignee: AMGEN INC.
    Inventors: Ashish Sharma, Balakumar Thangaraj
  • PHARMACEUTICAL COMPOSITION COMPRISING BISPECIFIC ANTIBODY CONSTRUCTS
    Publication number: 20230103401
    Abstract: The present invention provides novel and stable pharmaceutical compositions comprising bispecific single chain antibody constructs, cyclodextrins and a buffer.
    Type: Application
    Filed: June 30, 2022
    Publication date: April 6, 2023
    Inventors: Sekhar Kanapuram, Ramil Latypov, Balakumar Thangaraj, Cornelius Pompe
  • Purification Method for Bispecific antigen-binding Polypeptides with Enhanced Protein L Capture Dynamic Binding Capacity
    Publication number: 20220306741
    Abstract: The present invention provides a downstream purification method process for the production of bispecific antigen-binding polypeptides.
    Type: Application
    Filed: September 10, 2020
    Publication date: September 29, 2022
    Inventors: Ashish Sharma, Balakumar Thangaraj
  • Pharmaceutical composition comprising bispecific antibody constructs
    Patent number: 11419933
    Abstract: The present invention provides novel and stable pharmaceutical compositions comprising bispecific single chain antibody constructs, cyclodextrins and a buffer.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: August 23, 2022
    Assignees: AMGEN INC., AMGEN RESEARCH (MUNICH) GMBH
    Inventors: Sekhar Kanapuram, Ramil Latypov, Balakumar Thangaraj, Cornelius Pompe
  • A CONTINUOUS MANUFACTURING PROCESS FOR BIOLOGICS MANUFACTURING BY INTEGRATION OF DRUG SUBSTANCE AND DRUG PRODUCT PROCESSES
    Publication number: 20220119526
    Abstract: A biologics manufacturing process that connects the drug substance and drug product processes into an integrated, continuous process.
    Type: Application
    Filed: January 27, 2020
    Publication date: April 21, 2022
    Applicant: AMGEN INC.
    Inventors: Subramanian GUHAN, Malhar R. AMBHAIKAR, Vincent CHAI, Sai Chakradhar PADALA, Nitin RATHORE, Zane SAREMI, Kenneth SHOEMAKER, Benjamin J. TILLOTSON, Balakumar THANGARAJ, Philip CLARK, Ashish SHARMA, Hann-Chung WONG, John E. THORUP
  • METHODS FOR PURIFYING PROTEINS
    Publication number: 20200190137
    Abstract: The invention pertains to methods of purifying fusion proteins, in particular TNFR:Fc fusion proteins. Methods disclosed herein can be used to produce highly pure TNFR:Fc fusion proteins (e.g., etanercept) having a biological activity by removing hard to separate product related impurities such as clipped and/or mis-fold/aggregated TNFR:Fc fusion proteins.
    Type: Application
    Filed: December 10, 2019
    Publication date: June 18, 2020
    Applicant: AMGEN INC.
    Inventors: Ashish Sharma, Balakumar Thangaraj
  • PHARMACEUTICAL COMPOSITION COMPRISING BISPECIFIC ANTIBODY CONSTRUCTS
    Publication number: 20170209571
    Abstract: The present invention provides novel and stable pharmaceutical compositions comprising bispecific single chain antibody constructs, cyclodextrins and a buffer.
    Type: Application
    Filed: January 25, 2017
    Publication date: July 27, 2017
    Inventors: Sekhar Kanapuram, Ramil Latypov, Balakumar Thangaraj, Cornelius Pompe