Patents by Inventor Balakumar VIJAYAKRISHNAN

Balakumar VIJAYAKRISHNAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolobenzodiazepine conjugates
    Patent number: 11649250
    Abstract: A conjugate of formula (I) wherein Ab is a modified antibody having at least one free conjugation site on each heavy chain.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: May 16, 2023
    Assignee: MEDIMMUNE LIMITED
    Inventors: Nazzareno Dimasi, Philip Wilson Howard, Luke Masterson, Arnaud Charles Tiberghien, Balakumar Vijayakrishnan, Jason White
  • N-GLYCOSYLATION OF PEPTIDES AND PROTEINS
    Publication number: 20220025419
    Abstract: A process for the production of a glycoconjugate by N-glycosylation of a protein or peptide comprising the sequence D/E-X-N-X-S/T (SEQ ID NO:1), wherein each X is the same or different and is any natural amino acid other than proline, wherein the process comprises reacting the protein or peptide with a polyisoprenyl pyrophosphate of formula (I), or a salt thereof, in the presence of PglB: to produce the glycoconjugate comprising the protein or peptide having a saccharide [S1] linked to the asparagine in the sequence D/E-X-N-X-S/T (SEQ ID NO:1). Polyisoprenylpyrophosphates used as substrates in the biocatalytic process are also provided, as well as certain glycoconjugates.
    Type: Application
    Filed: March 2, 2021
    Publication date: January 27, 2022
    Inventors: Benjamin G. DAVIS, Balakumar VIJAYAKRISHNAN, Feng LIU, Michael WACKER, Amirreza FARIDMOAYER, Michael Thomas KOWARIK
  • PYRROLOBENZODIAZEPINE CONJUGATES
    Publication number: 20210283141
    Abstract: A conjugate of formula I: wherein Ab is a modified antibody having at least one free conjugation site on each heavy chain and each of RLL1 and RLL2 comprise the group:
    Type: Application
    Filed: May 24, 2019
    Publication date: September 16, 2021
    Inventors: Luke MASTERSON, Balakumar VIJAYAKRISHNAN, Ronald James CHRISTIE
  • PYRROLOBENZODIAZEPINE CONJUGATES
    Publication number: 20200247823
    Abstract: A conjugate of formula (I) wherein Ab is a modified antibody having at least one free conjugation site on each heavy chain.
    Type: Application
    Filed: August 17, 2018
    Publication date: August 6, 2020
    Inventors: Nazzareno DIMASI, Philip Wilson HOWARD, Luke MASTERSON, Arnaud Charles TIBERGHIEN, Balakumar VIJAYAKRISHNAN, Jason WHITE
  • N-GLYCOSYLATION OF PEPTIDES AND PROTEINS
    Publication number: 20160257983
    Abstract: A process for the production of a glycoconjugate by N-glycosylation of a protein or peptide comprising the sequence D/E-X—N—X—S/T, wherein each X is the same or different and is any natural amino acid other than proline, wherein the process comprises reacting the protein or peptide with a polyisoprenyl pyrophosphate of formula (I), or a salt thereof, in the presence of PglB: (I) to produce the glycoconjugate comprising the protein or peptide having a saccharide [SI] linked to the asparagine in the sequence D/E-X—N—X—S/T. Polyisoprenylpyrophosphates used as substrates in the biocatalytic process are also provided, as well as certain glycoconjugates.
    Type: Application
    Filed: October 15, 2014
    Publication date: September 8, 2016
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Benjamin G. DAVIS, Balakumar VIJAYAKRISHNAN, Feng LUI, Michael WACKER, Amirreza FARIDMOAYER, Michael Thomas KOWARIK