Patents by Inventor Balamurugan APPAKALAI

Balamurugan APPAKALAI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tissue constructs including pancreas derived microvessel fragments and related methods
    Patent number: 11464808
    Abstract: A tissue construct is provided that comprises a pancreas derived microvessel fragment and a pancreatic islet cell. The pancreas derived microvessel fragment and the pancreatic islet cell can be incorporated into a biocompatible medium. Tissue constructs can be comprised of other cells, such as stem cells, combined with the pancreas derived microvascular fragment. Methods for isolating microvessel fragments from a pancreas are also provided and include enzymatic digestion of pancreatic tissue and separation of microvessel fragments from endocrine and exocrine tissue. Methods for treating diabetes are further provided and include administration of the tissue constructs.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: October 11, 2022
    Assignee: University of Louisville Research Foundation
    Inventors: Balamurugan Appakalai, Stuart K. Williams
  • TISSUE CONSTRUCTS INCLUDING PANCREAS DERIVED MICROVESSEL FRAGMENTS AND RELATED METHODS
    Publication number: 20200054685
    Abstract: A tissue construct is provided that comprises a pancreas derived microvessel fragment and a pancreatic islet cell. The pancreas derived microvessel fragment and the pancreatic islet cell can be incorporated into a biocompatible medium. Tissue constructs can be comprised of other cells, such as stem cells, combined with the pancreas derived microvascular fragment. Methods for isolating microvessel fragments from a pancreas are also provided and include enzymatic digestion of pancreatic tissue and separation of microvessel fragments from endocrine and exocrine tissue. Methods for treating diabetes are further provided and include administration of the tissue constructs.
    Type: Application
    Filed: April 27, 2018
    Publication date: February 20, 2020
    Inventors: Balamurugan APPAKALAI, Stuart K. WILLIAMS