Patents by Inventor Balaraman Kalyanaraman

Balaraman Kalyanaraman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhanced Anti-Proliferative and Antitumor Immune Effects of Mitochondria-Targeted Hydroxyurea
    Publication number: 20240109925
    Abstract: In the present invention, the inventors provide substituted the hydroxyl group in hydroxyurea (HU) with a triphenylphosphonium (TPP) cation attached to an alkyl group with different chain lengths, generating a new class of mitochondria-targeted hydroxyurea compounds (Mito-HUs). Elongating the alkyl side chain length increased the hydrophobicity of Mito-HUs, and correlated with increased inhibition of oxidative phosphorylation, and antiproliferative effects in tumor cells.
    Type: Application
    Filed: January 26, 2022
    Publication date: April 4, 2024
    Inventors: Balaraman Kalyanaraman, Gang Cheng, Micael Joel Hardy
  • Mito-honokiol compounds and methods of synthesis and use thereof
    Patent number: 11897910
    Abstract: The present invention provides mito-honokiol or mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol or mito-magnolol compounds in the treatment of cancer.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: February 13, 2024
    Assignees: The Medical College of Wisconsin, Inc., Aix-Marseille Universite
    Inventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael J. Hardy, Olivier Ouari, Ming You
  • Mito-magnolol compounds and methods of synthesis and use thereof
    Patent number: 11612610
    Abstract: The present invention provides mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-magnolol compounds in the treatment of cancer, especially anti-cancer therapy or kinase resistant cancers.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: March 28, 2023
    Assignees: Medical College of Wisconsin, Inc., Aix-Marseille Universite
    Inventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael Joël Hardy, Olivier Ouari
  • Mitochondria-Targeted Atovaqone: A More Potent and More Effective Antitumor, Antimicrobial, and Antimalarial Drug
    Publication number: 20230017373
    Abstract: The present invention provides novel mitochondria-targeted Atovaquone compounds (Mito-ATO), a mitochondria-targeted derivative of Atovaquone, and methods of using such compounds. Methods of treating cancer using mito-ATO are also provided. Methods of enhancing an anti-tumor immune response by administering mito-ATO are further provided.
    Type: Application
    Filed: October 26, 2020
    Publication date: January 19, 2023
    Inventors: Balaraman Kalyanaraman, Gang Cheng, Micael Joël Hardy
  • Mito-Magnolol Compounds and Methods of Synthesis and Use Thereof
    Publication number: 20220211727
    Abstract: The present invention provides mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-magnolol compounds in the treatment of cancer, especially anti-cancer therapy or kinase resistant cancers.
    Type: Application
    Filed: August 9, 2021
    Publication date: July 7, 2022
    Inventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael Joël Hardy, Olivier Ouari
  • Mito-lonidamine, compositions and methods of use
    Patent number: 11352382
    Abstract: The present invention relates to mito-lonidamine compounds, compositions and methods of use in the treatment of cancer.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: June 7, 2022
    Assignees: The Medical College of Wisconsin, Inc., Aix-Marseille Universite
    Inventors: Balaraman Kalyanaraman, Micael J. Hardy, Olivier Ouari
  • Targeting Redox-Active Pyridinium Cations to Mitochondria to Inhibit Proliferation of Drug-Resistant Cancer Cells
    Publication number: 20210395280
    Abstract: The present invention provides novel mito-pyridinium compounds, prodrugs and the uses thereof for the treatment of cancer, particularly drug resistant cancer.
    Type: Application
    Filed: November 1, 2019
    Publication date: December 23, 2021
    Inventors: Jacek Michal Zielonka, Adam Bartlomiej Sikora, Balaraman Kalyanaraman
  • Mito-magnolol compounds and methods of synthesis and use thereof
    Patent number: 11083739
    Abstract: The present invention provides mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-magnolol compounds in the treatment of cancer, especially anti-cancer therapy or kinase resistant cancers.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: August 10, 2021
    Assignees: THE MEDICAL COLLEGE OF WISCONSIN, INC., AIX-MARSEILLE UNIVERSITE
    Inventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael Joël Hardy, Olivier Ouari
  • Mito-Honokiol Compounds and Methods of Synthesis and Use Thereof
    Publication number: 20210070787
    Abstract: The present invention provides mito-honokiol or mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol or mito-magnolol compounds in the treatment of cancer.
    Type: Application
    Filed: November 16, 2020
    Publication date: March 11, 2021
    Inventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael J. Hardy, Olivier Ouari, Ming You
  • MITO-LONIDAMINE, COMPOSITIONS AND METHODS OF USE
    Publication number: 20210061830
    Abstract: The present invention relates to mito-lonidamine compounds, compositions and methods of use in the treatment of cancer.
    Type: Application
    Filed: January 3, 2019
    Publication date: March 4, 2021
    Inventors: Balaraman KALYANARAMAN, Micael J. HARDY, Olivier OUARI
  • Mito-honokiol compounds and methods of synthesis and use thereof
    Patent number: 10836782
    Abstract: The present invention provides mito-honokiol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol compounds in the treatment of cancer.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: November 17, 2020
    Assignees: The Medical College of Wisconsin, Inc., Aix-Marseille Universite
    Inventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Micael J. Hardy, Oliver Ouari, Ming You
  • MITO-MAGNOLOL COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF
    Publication number: 20200222433
    Abstract: The present invention provides mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-magnolol compounds in the treatment of cancer, especially anti-cancer therapy or kinase resistant cancers.
    Type: Application
    Filed: December 13, 2019
    Publication date: July 16, 2020
    Applicants: THE MEDICAL COLLEGE OF WISCONSIN, INC., AIX-MARSEILLE UNIVERSITE
    Inventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael Joël Hardy, Olivier Ouari
  • Neuroprotection by mitochondria-targeted metformin
    Patent number: 10576093
    Abstract: The present invention provides modified metformin compounds, particularly mito-metformin compounds, and pharmaceutical compositions thereof. Methods of using the compounds to provide neuroprotection and in the treatment and/or prevention of neurodegenerative diseases are also described.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: March 3, 2020
    Assignees: Iowa State University Research Foundation, Inc., The Medical College of Wisconsin, Inc.
    Inventors: Anumantha Kanthasamy, Balaraman Kalyanaraman
  • SYNERGISTIC INIHIBITION OF TUMOR CELL PROLIFERATION INDUCED BY COMBINED TREATMENT OF METFORMIN OR METFORMIN ANALOGS AND IRON CHELATORS
    Publication number: 20190358247
    Abstract: The present invention is directed to combination therapy comprising metformin or mito-metformin compounds with at least one iron chelating agent for the treatment of cancer and pharmaceutical compositions thereof.
    Type: Application
    Filed: December 21, 2017
    Publication date: November 28, 2019
    Inventors: Balaraman Kalyanaraman, Christopher R. Chltambar
  • Neuroprotection by mitochondria-targeted metformin
    Publication number: 20190091245
    Abstract: The present invention provides modified metformin compounds, particularly mito-metformin compounds, and pharmaceutical compositions thereof. Methods of using the compounds to provide neuroprotection and in the treatment and/or prevention of neurodegenerative diseases are also described.
    Type: Application
    Filed: April 26, 2018
    Publication date: March 28, 2019
    Inventors: Anumantha Kanthasamy, Balaraman Kalyanaraman
  • MITO-HONOKIOL COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF
    Publication number: 20180134737
    Abstract: The present invention provides mito-honokiol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol compounds in the treatment of cancer.
    Type: Application
    Filed: June 10, 2016
    Publication date: May 17, 2018
    Inventors: Balaraman KALYANARAMAN, Jacek Michal Zlelonka, Micael J. Hardy, Oliver Ouari, Ming You
  • Neuroprotection by mitochondria-targeted metformin
    Patent number: 9956233
    Abstract: The present invention provides modified metformin compounds, particularly mito-metformin compounds, and pharmaceutical compositions thereof. Methods of using the compounds to provide neuroprotection and in the treatment and/or prevention of neurodegenerative diseases are also described.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: May 1, 2018
    Assignees: Iowa State University Research Foundation, Inc., The Medical College of Wisconsin, Inc.
    Inventors: Anumantha Kanthasamy, Balaraman Kalyanaraman
  • Neuroprotection by Mitochondria-Targeted Metformin
    Publication number: 20170106006
    Abstract: The present invention provides modified metformin compounds, particularly mito-metformin compounds, and pharmaceutical compositions thereof. Methods of using the compounds to provide neuroprotection and in the treatment and/or prevention of neurodegenerative diseases are also described.
    Type: Application
    Filed: October 14, 2016
    Publication date: April 20, 2017
    Inventors: Anumantha Kanthasamy, Balaraman Kalyanaraman
  • Neuroprotective compounds and their use
    Patent number: 8962600
    Abstract: Apocynin derivative compounds, active pharmaceutical ingredients, dosage forms, and methods of use thereof as neuroprotectants in the brain of mammals.
    Type: Grant
    Filed: April 15, 2010
    Date of Patent: February 24, 2015
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Balaraman Kalyanaraman, Joy Joseph, Anumantha Kanthasamy
  • MITOCHONDRIA TARGETED CATIONIC ANTI-OXIDANT COMPOUNDS FOR PREVENTION, THERAPY OR TREATMENT OF HYPER-PROLIFERATIVE DISEASE, NEOPLASIAS AND CANCERS
    Publication number: 20130338110
    Abstract: The inventions disclosed include methods of treating cancers and related neoplasias, especially prostate cancer, with pharmaceutically acceptable salts comprising lipophilic cation moieties linked to nitroxide or linked to hydroxylamine anti-oxidant groups.
    Type: Application
    Filed: May 20, 2013
    Publication date: December 19, 2013
    Inventors: David A. ZARLING, Hirak S. BASU, Balaraman KALYANARAMAN, Joy JOSEPH