Patents by Inventor Balazs G. Szoke

Balazs G. Szoke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thermal Denaturation Screening Assay to Identify Candidate Compounds for Prevention and Treatment of Parkinson's Disease
    Publication number: 20090226946
    Abstract: The invention provides highthroughput screening assays to identify agents useful for treatment of Parkinson's Disease. In one embodiment the assay includes exposing a plurality of test samples, each containing a test compound and parkin protein, to thermal destabilization conditions and determining parkin ligase activity in the test samples relative to a control sample not containing a test agent. A test agent contained in a test sample in which parkin ligase activity exceeds the ligase activity in said control sample is identified as a candidate compound for treatment of Parkinson's Disease.
    Type: Application
    Filed: January 29, 2009
    Publication date: September 10, 2009
    Applicant: Elan Pharmaceuticals, Inc.
    Inventors: Jennifer A. Johnston, Balazs G. Szoke, Lisa McConlogue
  • Voltage-gated calcium channel antagonist and method
    Patent number: 6653460
    Abstract: A novel class of peptides selectively block class E voltage-gated calcium channels. The class is exemplified by HG peptides such as HG-1, which is isolated from the venom-producing cells of the tarantula Hysterocrates gigas. Also disclosed are methods of producing blocking class E channels using the peptides. HG peptides have utility, for example, in inhibiting oxytocin release and for use as anticonvulsants.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: November 25, 2003
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Robert Newcomb, Andrew L. Palma, Balazs G. Szoke, Katalin Tarczy-Hornoch, William F. Hopkins, Ruth L. Cong, George P. Miljanich, Robin Dean, Laszlo Nadasdi, Laszlo Urge, Stephen Scott Bowersox
  • Peptidyl calcium channel blockers
    Patent number: 6423689
    Abstract: The present invention provides compounds that block calcium channels having the Formula I shown below. The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, or epilepsy and to pharmaceutical compositions that contain the compounds of Formula I.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: July 23, 2002
    Assignees: Warner-Lambert Company, Neurex Corporation
    Inventors: Richard John Booth, Louis Brogley, Wayne Livingston Cody, David Thomas Connor, Harriet Wall Hamilton, John Xiaoqiang He, Lain-Yen Hu, Leonard Joseph Lescosky, Thomas Charles Malone, Laszlo Nadasdi, Michael Francis Rafferty, Bruce David Roth, Diego F. Silva, Yuntao Song, Balazs G. Szoke, Laszlo Urge
  • Voltage-gated calcium channel antagonist and method
    Patent number: 6156726
    Abstract: A novel class of peptides selectively block class E voltage-gated calcium channels. The class is exemplified by HG peptides such as HG-1, which is isolated from the venom-producing cells of the tarantula Hysterocrates gigas. Also disclosed are methods of producing blocking class E channels using the peptides. HG peptides have utility, for example, in inhibiting oxytocin release and for use as anticonvulsants.
    Type: Grant
    Filed: August 1, 1997
    Date of Patent: December 5, 2000
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Robert Newcomb, Andrew L. Palma, Balazs G. Szoke, Katalin Tarczy-Hornoch, William F. Hopkins, Ruth L. Cong, George P. Miljanich, Robin Dean, Laszlo Nadasdi, Laszlo Urge, Stephen Scott Bowersox
  • Substituted peptidylamine calcium channel blockers
    Patent number: 6117841
    Abstract: The present invention provides compounds that block calcium channels having the Formula I shown below. ##STR1## The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, or epilepsy and to pharmaceutical compositions that contain the compounds of Formula I.
    Type: Grant
    Filed: January 19, 1999
    Date of Patent: September 12, 2000
    Assignee: Warner-Lambert Company
    Inventors: Lain-Yen Hu, Thomas Charles Malone, Laszlo Nadasdi, Michael Francis Rafferty, Todd Robert Ryder, Diego F. Silva, Yuntao Song, Balazs G. Szoke, Laszlo Urge