Patents by Inventor Baldomero Olivera
Baldomero Olivera has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150322120Abstract: The present invention relates to conopeptides that are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which block the sodium channels.Type: ApplicationFiled: April 17, 2013Publication date: November 12, 2015Applicants: University of Utah Research Foundation, Janssen Pharmaceutica NVInventors: Julita Imperial, Brad Reed Green, Joanna Gajewiak, Minmin Zhang, Doju Yoshikami, Grzegorz Bulaj, Baldomero Olivera, Alan Wickenden, Yi Liu
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Publication number: 20100197567Abstract: The invention relates to peptides (termed propeller peptides herein) and related peptides (termed peptides of the G12.2 family herein), about 60 to about 90 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which blocks the desensitization of AMPA-type ionotropic glutamate receptors (AMPARs).Type: ApplicationFiled: October 16, 2009Publication date: August 5, 2010Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventors: Andres Villu MARICQ, Stori JENSEN, Craig WALKER, David MADSEN, Baldomero OLIVERA, Michael ELLISON
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Publication number: 20080274976Abstract: The present invention is directed to kappaM (?M) conopeptide RIIIK and its use for blocking the flow of potassium ions through voltage-gated potassium channels. The ?M conopeptides include unglycosylated and O-glycosylated peptides.Type: ApplicationFiled: February 11, 2008Publication date: November 6, 2008Applicants: UNIVERSITY OF UTAH RESEARCH FOUNDATION, MAX-PLANCK-GESELLSCHAFT zur FORDERUNG der WISSENSCHAFTEN e.V.Inventors: Baldomero OLIVERA, Maren WATKINS, Heinrich TERLAU, Michael FERBER
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Publication number: 20080089844Abstract: The invention relates to ?M conopeptides and their use as organ protecting agents, i.e., organ protectants. These conotoxins can be used for arresting, protecting or preserving an organ, such as a circulatory organ, a respiratory organ, a urinary organ, a digestive organ, a reproductive organ, an endocrine organ or a neurological organ. These conotoxins can also be used for arresting, protecting or preserving somatic cells.Type: ApplicationFiled: April 18, 2007Publication date: April 17, 2008Inventor: Baldomero Olivera
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Publication number: 20080081901Abstract: The invention relates to relatively short peptides (termed ?-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.Type: ApplicationFiled: October 9, 2007Publication date: April 3, 2008Applicants: THE UNIVERSITY OF UTAH RESEARCH FOUNDATION, COGNETIX, INC.Inventors: Maren WATKINS, Baldomero OLIVERA, David HILLYARD, J. MCINTOSH, Robert JONES
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Publication number: 20070173457Abstract: The invention relates to relatively short peptides (termed ?-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.Type: ApplicationFiled: November 7, 2005Publication date: July 26, 2007Applicants: The University of Utah Research Foundation, Cognetix, Inc.Inventors: Craig Walker, Reshma Shetty, Baldomero Olivera, David Hooper, Richard Jacobsen, Doug Steel, Robert Jones
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Publication number: 20060257843Abstract: The invention relates to ?-PVIIA-related conotoxins and their use as organ protecting agents, i.e., organ protectants. These conotoxins can be used for arresting, protecting or preserving an organ, such as a circulatory organ, a respiratory organ, a urinary organ, a digestive organ, a reproductive organ, an endocrine organ or a neurological organ. These conotoxins can also be used for arresting, protecting or preserving somatic cells.Type: ApplicationFiled: July 21, 2006Publication date: November 16, 2006Applicants: Cognetix, Inc., University of Utah Research FoundationInventors: Karen Pemberton-Goodman, Robert Jones, Davis Temple, J. McIntosh, Baldomero Olivera
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Publication number: 20060247173Abstract: The invention relates to relatively short peptides (termed ?-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The ?-conotoxins, as described herein, are useful for as neuromuscular blocking agents, such as muscle relaxants.Type: ApplicationFiled: July 7, 2006Publication date: November 2, 2006Applicants: The University of Utah Research Foundation, Cognetix, Inc.Inventors: Baldomero Olivera, Richard Layer, Maren Watkins, David Hillyard, J. McIntosh, Robert Schoenfeld, Jacob Nielsen, Robert Jones
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Publication number: 20060241046Abstract: The invention relates to linear y-carboxyglutamate rich conotoxins, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.Type: ApplicationFiled: June 29, 2006Publication date: October 26, 2006Applicants: University of Utah Research Foundation, Cognetix, Inc.Inventors: Baldomero Olivera, J. McIntosh, James Garrett, Craig Walker, Maren Watkins, Robert Jones
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Publication number: 20060223984Abstract: This invention relates to relatively short peptides about 25-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogs to the naturally available peptides, and which include three cyclizing disulfide linkages and one or more ?carboxyglutamate residues.Type: ApplicationFiled: August 26, 2003Publication date: October 5, 2006Applicants: Cognetix Inc., University of Utah Research FoundationInventors: Michael Fainzilber, Karel Kits, Alma Burlingame, Baldomero Olivera, Craig Walker, Maren Watkins, Reshma Shetty, Lourdes Cruz, Julita Imperial, Clark Colledge
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Publication number: 20060205656Abstract: The present invention is directed to P-superfamily conopeptides, to DNA encoding precursors of the P-superfamily conopeptides and to the precursor peptides.Type: ApplicationFiled: March 27, 2006Publication date: September 14, 2006Applicants: Cognetix, Inc., University of Utah Research FoundationInventors: David Hooper, James Garrett, Gloria Corpuz, Lourdes Cruz, Baldomero Olivera, J. McIntosh, Robert Jones
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Publication number: 20060199245Abstract: Protein disulfide isomerase is a major component of Conus venom ducts. The invention relates to a protein disulfide isomerase (PDI) from Conus snails, a nucleic acid sequence encoding the Conus protein disulfide isomerase, and to methods for folding disulfide-rich peptides using a protein disulfide isomerase. Oxidative folding of conotoxin precursors, catalyzed by a PDI, was more efficient and decreased the number and concentration of transiently accumulated folding species. The PDI-assisted oxidative folding of conotoxins was also influenced by the propeptide relative to the mature peptide.Type: ApplicationFiled: August 31, 2005Publication date: September 7, 2006Inventors: Grzegorz Bulaj, Baldomero Olivera, Olga Buczek, James Garrett, Ian Goodsell
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Publication number: 20060178303Abstract: The present invention is directed to conopeptides termed conkunitzins and their use for blocking the flow of potassium ions through voltage-gated potassium channels. In view of the Kunitz domain in the conkunitzins, they are also useful for inhibiting platelet aggregation and as protease inhibitors.Type: ApplicationFiled: September 9, 2005Publication date: August 10, 2006Applicants: University of Utah Research Foundation, Cognetix, Inc., Maz-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.Inventors: Baldomero Olivera, Heinrich Terlau, Julita Imperial, James Garrett
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Publication number: 20060172948Abstract: The invention relates to ?-carboxyglutamate containing conopeptides, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.Type: ApplicationFiled: March 22, 2006Publication date: August 3, 2006Applicants: University of Utah Research Foundation, Cognetix, Inc.Inventors: Baldomero Olivera, J. McIntosh, James Garrett, Craig Walker, Maren Watkins, Robert Jones
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Publication number: 20060014673Abstract: The present invention is directed to kappaA (?A) conopeptides and the use of these peptides for blocking the flow of potassium ions through voltage-gated potassium channels. The ?A conopeptides include unglycosylated and O-glycosylated peptides.Type: ApplicationFiled: July 6, 2005Publication date: January 19, 2006Applicants: Cognetix, Inc., University of Utah Research FoundationInventors: Richard Layer, Karen Pemberton, Robert Jones, James Garrett, Baldomero Olivera, J. McIntosh, David Hillyard, Michelle Grilley, Maren Watkins, Ameurfina Santos, Glenn Zafaralla, A. Craig
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Publication number: 20050271589Abstract: The present invention is directed to ?-superfamily conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, ligand gated channels and other receptors. The invention is further directed to nucleic acid sequences encoding the ?-superfamily conotoxin peptides and encoding ?-superfamily conotoxin propeptides, as well as the ?-superfamily conotoxin propeptides.Type: ApplicationFiled: August 8, 2005Publication date: December 8, 2005Applicants: University of Utah Research Foundation, Cognetix, Inc.Inventors: Robert Jones, Baldomero Olivera, Maren Watkins, James Garrett
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Publication number: 20050214903Abstract: The invention relates to relatively short peptides (termed O-Superfamily conotoxins herein), about 20-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.Type: ApplicationFiled: May 6, 2004Publication date: September 29, 2005Applicants: The University of Utah Research Foundation, Cognetix, Inc.Inventors: Baldomero Olivera, G. Cartier, Maren Watkins, David Hillyard, J. McIntosh, Richard Layer, Robert Jones
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Publication number: 20050214213Abstract: The present invention is directed to conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, voltage-gated ligand channels and/or receptors. The invention is further directed to nucleic acid sequences encoding the conotoxin peptides and encoding propeptides, as well as the propeptides.Type: ApplicationFiled: April 4, 2005Publication date: September 29, 2005Applicants: University of Utah, CognetixInventors: Baldomero Olivera, J. McIntosh, Maren Watkins, James Garrett, Lourdes Cruz, Michelle Grilley, Robert Schoenfeld, Craig Walker, Reshma Shetty, Robert Jones
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Publication number: 20050203003Abstract: The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr10-contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.Type: ApplicationFiled: February 8, 2002Publication date: September 15, 2005Applicants: University of Utah Research Foundation, Cognetix, Inc., The Salk Institute for Biological StudiesInventors: A. Craig, David Griffin, Baldomero Olivera, Maren Watkins, David Hillyard, Julita Imperial, Lourdes Cruz, John Wagstaff, Richard Layer, Robert Jones, R. McCabe
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Publication number: 20050159586Abstract: The invention relates to linear ?-carboxyglutamate rich conotoxins, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvillsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.Type: ApplicationFiled: December 22, 2004Publication date: July 21, 2005Applicants: University of Utah Research Foundation, Cognetix, Inc.Inventors: Baldomero Olivera, J. McIntosh, James Garrett, Craig Walker, Maren Watkins, Robert Jones