Patents by Inventor Balendu Shekhar Jha

Balendu Shekhar Jha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DRUGGABLE TARGET TO TREAT RETINAL DEGENERATION
    Publication number: 20220339127
    Abstract: This invention relates to novel method of treating or ameliorating a retinal disease or disorder or retinal degradation in a subject and a novel method of restoring retinal pigment epithelium cell compromising the administration of a one or more compounds which modulate Nox4, formation of radical oxygen species, serine protease, a dopamine receptor, NF-kB, mTOR, AMPK, RPE epithelial to mesenchymal transition, RPE dedifferentiation, or one or more Rho GTPases; and kits for administration of the methods.
    Type: Application
    Filed: September 11, 2020
    Publication date: October 27, 2022
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Kapil Bharti, Karla Yadira Barbosa Sabanero, Justin Ren Yuan Chang, Balendu Shekhar Jha, Ruchi Sharma
  • METHOD FOR REPRODUCIBLE DIFFERENTIATION OF CLINICAL-GRADE RETINAL PIGMENT EPITHELIUM CELLS
    Publication number: 20210139847
    Abstract: Provided herein are methods of producing an RPE cell population from a starting cell suspension, such as a single cell suspension, of pluripotent stem cells (PSCs). Such a method may comprise culturing the starting single cell suspension of PSCs in differentiation media to produce human RPE cells.
    Type: Application
    Filed: July 16, 2020
    Publication date: May 13, 2021
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, FUJIFILM Cellular Dynamics, Inc.
    Inventors: Kapil Bharti, Lucas Chase, Feng Xuezhu, Balendu Shekhar Jha
  • METHOD FOR REPRODUCIBLE DIFFERENTIATION OF CLINICAL-GRADE RETINAL PIGMENT EPITHELIUM CELLS
    Publication number: 20190169569
    Abstract: Provided herein are methods of producing an RPE cell population from a starting cell suspension, such as a single cell suspension, of pluripotent stem cells (PSCs). Such a method may comprise culturing the starting single cell suspension of PSCs in differentiation media to produce human RPE cells.
    Type: Application
    Filed: September 7, 2016
    Publication date: June 6, 2019
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Serv, Cellular Dynamics International, Inc.
    Inventors: Kapil Bharti, Lucas Chase, Feng Xuezhu, Balendu Shekhar Jha
  • Electrospun nerve guides for nerve regeneration designed to modulate nerve architecture
    Patent number: 9572909
    Abstract: Nerve guides which are formed from three dimensional (3D) arrays of highly aligned electrospun fibers are provided. The electrospun fibers are oriented parallel to the long axis of the guide, and gaps and elongated spaces between the stacked fiber arrays provide channels for directed axonal growth. In some embodiments, the nerve guides also comprise high precision gradients of beneficial substances such as growth factors, which aid in nerve regeneration and growth along the guide.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: February 21, 2017
    Assignee: Virginia Commonwealth University
    Inventors: David Simpson, Gary Bowlin, Raymond Colello, Woon Chow, Balendu Shekhar Jha
  • ELECTROSPUN NERVE GUIDES FOR NERVE REGENERATION DESIGNED TO MODULATE NERVE ARCHITECTURE
    Publication number: 20120221025
    Abstract: Nerve guides which are formed from three dimensional (3D) arrays of highly aligned electrospun fibers are provided. The electrospun fibers are oriented parallel to the long axis of the guide, and gaps and elongated spaces between the stacked fiber arrays provide channels for directed axonal growth. In some embodiments, the nerve guides also comprise high precision gradients of beneficial substances such as growth factors, which aid in nerve regeneration and growth along the guide.
    Type: Application
    Filed: September 14, 2010
    Publication date: August 30, 2012
    Inventors: David Simpson, Gary Bowlin, Raymond Colello, Woon Chow, Balendu Shekhar Jha