Patents by Inventor Balint Csorgo

Balint Csorgo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRISPR-CAS3 FOR MAKING GENOMIC DELETIONS AND INDUCING RECOMBINATION
    Publication number: 20220356470
    Abstract: The present disclosure provides methods and compositions for generating deletions, inducing recombination, and for modulating gene expression in cells using type I CRISPR-Cas systems.
    Type: Application
    Filed: June 19, 2020
    Publication date: November 10, 2022
    Applicant: The Regents of the University of California
    Inventors: Lina Maria Leon, Balint Csorgo, Joseph Bondy-Denomy
  • Mutagenizing intracellular nucleic acids
    Patent number: 10669537
    Abstract: A method of in vivo mutagenesis of a preselected target region (PTR) of an intracellular DNA within a cell culture, which PTR comprises at least one sequence of interest (SOI) which is at least 60 nucleobases long, the method comprising: a) providing a pool of partially overlapping single stranded DNA (ssDNA) oligonucleotides which upon alignment form a continuous sequence that is complementary to the SOI, wherein the pool contains a diversity of mutagenizing oligonucleotides covering nucleobase mismatches at every position of said SOI and combination of said nucleobase mismatches, wherein each mutagenizing oligonucleotide is hybridizing with the PTR and comprises at least one mismatching nucleobase up to 20% mismatching nucleobases, compared to the SOI; b) integrating the pool into said intracellular DNA by homologous recombination and inducing in vivo mutagenesis of the intracellular DNA through hybridizing the oligonucleotides to the PTR, thereby producing a cell library comprising a repertoire of variant
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: June 2, 2020
    Assignee: BIOLOGICAL RESEARCH CENTRE
    Inventors: Akos Jozsef Nyerges, Csaba Pal, Balint Csorgo, Balint Kintses
  • MUTAGENIZING INTRACELLULAR NUCLEIC ACIDS
    Publication number: 20200017850
    Abstract: A method of in vivo mutagenesis of a preselected target region (PTR) of an intracellular DNA within a cell culture, which PTR comprises at least one sequence of interest (SOI) which is at least 60 nucleobases long, the method comprising: a) providing a pool of partially overlapping single stranded DNA (ssDNA) oligonucleotides which upon alignment form a continuous sequence that is complementary to the SOI, wherein the pool contains a diversity of mutagenizing oligonucleotides covering nucleobase mismatches at every position of said SOI and combination of said nucleobase mismatches, wherein each mutagenizing oligonucleotide is hybridizing with the PTR and comprises at least one mismatching nucleobase up to 20% mismatching nucleobases, compared to the SOI; b) integrating the pool into said intracellular DNA by homologous recombination and inducing in vivo mutagenesis of the intracellular DNA through hybridizing the oligonucleotides to the PTR, thereby producing a cell library comprising a repertoire of variant
    Type: Application
    Filed: December 13, 2017
    Publication date: January 16, 2020
    Inventors: Akos Jozsef NYERGES, Csaba PAL, Balint CSORGO, Balint KINTSES
  • Reduced genome bacteria with improved genetic stability
    Patent number: 9914905
    Abstract: Reduced genome bacteria with improved genetic stability are provided. Also provided are methods of producing polypeptides using the reduced genome bacteria with improved genetic stability.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: March 13, 2018
    Assignee: SCARAB GENOMICS, LLC
    Inventors: Frederick R. Blattner, Balint Csorgo, Gyorgy Posfai
  • Reduced Genome Bacteria With Improved Genetic Stability
    Publication number: 20170114318
    Abstract: Reduced genome bacteria with improved genetic stability are provided. Also provided are methods of producing polypeptides using the reduced genome bacteria with improved genetic stability.
    Type: Application
    Filed: December 29, 2016
    Publication date: April 27, 2017
    Inventors: Frederick R. BLATTNER, Balint CSORGO, Gyorgy POSFAI
  • Reduced Genome Bacteria With Improved Genetic Stability
    Publication number: 20160251609
    Abstract: Reduced genome bacteria with improved genetic stability are provided. Also provided are methods of producing polypeptides using the reduced genome bacteria with improved genetic stability.
    Type: Application
    Filed: May 13, 2016
    Publication date: September 1, 2016
    Applicant: SCARAB GENOMICS, LLC
    Inventors: Frederick R. BLATTNER, Balint CSORGO, Gyorgy POSFAL
  • Reduced genome bacteria with improved genetic stability
    Patent number: 9340791
    Abstract: Reduced genome bacteria with improved genetic stability are provided. Also provided are methods of producing polypeptides using the reduced genome bacteria with improved genetic stability.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: May 17, 2016
    Assignee: SCARAB GENOMICS, LLC
    Inventors: Frederick R. Blattner, Balint Csorgo, Gyorgy Posfai
  • Reduced Genome Bacteria With Improved Genetic Stability
    Publication number: 20140302555
    Abstract: Reduced genome bacteria with improved genetic stability are provided. Also provided are methods of producing polypeptides using the reduced genome bacteria with improved genetic stability.
    Type: Application
    Filed: October 19, 2012
    Publication date: October 9, 2014
    Applicant: SCARAB GENOMICS, LLC
    Inventors: Frederick R. Blattner, Balint Csorgo, Gyorgy Posfai