Patents by Inventor Balu Chakravarthy

Balu Chakravarthy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies and antibody fragments against HNAV1.7 channel and their use in pain and cancer indications
    Patent number: 11945858
    Abstract: The present disclosure concerns antibodies specific for the Na v.7 polypeptides which are capable of antagonizing the biological activity of the Na v.7 polypeptide. The anti-Na v.7 antibodies can be used for alleviating the symptoms of pain and/or for treating or alleviating the symptoms of an hyperproliferative disease. The presence disclosure also concerns immunogens and methods for making antibodies, such as the anti-Na v.7 antibodies, comprising a single-domain antibody.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: April 2, 2024
    Assignee: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Marzia Martina, Balu Chakravarthy, Yves Durocher, Mehdi Arbabi-Ghahroudi, Anne Marcil, Danica Stanimirovic, Traian Sulea, Maria Moreno, Umberto Banderali
  • FUSION PROTEIN COMPRISING A BLOOD-BRAIN BARRIER (BBB)-CROSSING SINGLE DOMAIN ANTIBODY FC5, AN IMMUNOGLOBULIN FC FRAGMENT AND A BETA-AMYLOID BINDING POLYPEPTIDE (ABP)
    Publication number: 20230279088
    Abstract: A brain-penetrating composition of amyloid-? binding peptide is disclosed. This may be useful in the treatment of Alzheimer's disease, for example as a bifunctional molecule, comprising a blood-brain barrier crossing antibody and an amyloid-? targeting peptide linked via an Fc fragment that is able to transmigrate across the blood-brain barrier into the brain, and compositions comprising same. Methods of using this composition for treating Alzheimer's disease are disclosed.
    Type: Application
    Filed: March 14, 2023
    Publication date: September 7, 2023
    Inventors: Balu Chakravarthy, Danica Stanimirovic, Yves Durocher
  • BLOOD-BRAIN BARRIER TRANSMIGRATING COMPOUNDS AND USES THEREOF
    Publication number: 20230257424
    Abstract: A brain-penetrating composition of amyloid-ß binding peptide is disclosed. This may be useful in the treatment of Alzheimer's disease, for example as a bifunctional molecule, comprising a blood-brain barrier crossing antibody and an amyloid-ß targeting peptide linked via an Fc fragment that is able to transmigrate across the blood-brain barrier into the brain, and compositions comprising same. Methods of using this composition for treating Alzheimer's disease are disclosed.
    Type: Application
    Filed: July 31, 2018
    Publication date: August 17, 2023
    Applicant: National Research Council of Canada
    Inventors: Balu Chakravarthy, Danica Stanimirovic, Yves Durocher
  • Fusion protein comprising a blood-brain barrier (BBB)-crossing single domain antibody Fc5, an immunoglobulin Fc fragment and a beta-amyloid binding polypeptide (ABP)
    Patent number: 11702466
    Abstract: A brain-penetrating composition of amyloid-ß binding peptide is disclosed. This may be useful in the treatment of Alzheimer's disease, for example as a bifunctional molecule, comprising a blood-brain barrier crossing antibody and an amyloid-ß targeting peptide linked via an Fc fragment that is able to transmigrate across the blood-brain barrier into the brain, and compositions comprising same. Methods of using this composition for treating Alzheimer's disease are disclosed.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: July 18, 2023
    Assignee: National Research Council of Canada
    Inventors: Balu Chakravarthy, Danica Stanimirovic, Yves Durocher
  • ANTIBODIES AND ANTIBODY FRAGMENTS AGAINST HNAV1.7 CHANNEL AND THEIR USE IN PAIN AND CANCER INDICATIONS
    Publication number: 20210206842
    Abstract: The present disclosure concerns antibodies specific for the Na v.7 polypeptides which are capable of antagonizing the biological activity of the Na v.7 polypeptide. The anti-Na v.7 antibodies can be used for alleviating the symptoms of pain and/or for treating or alleviating the symptoms of an hyperproliferative disease. The presence disclosure also concerns immunogens and methods for making antibodies, such as the anti-Na v.7 antibodies, comprising a single-domain antibody.
    Type: Application
    Filed: May 17, 2019
    Publication date: July 8, 2021
    Inventors: Marzia MARTINA, Balu CHAKRAVARTHY, Yves DUROCHER, Mehdi ARBABI-GHAHROUDI, Anne MARCIL, Danica STANIMIROVIC, Traian SULEA, Maria MORENO, Umberto BANDERALI
  • BLOOD-BRAIN BARRIER TRANSMIGRATING COMPOUNDS AND USES THEREOF
    Publication number: 20190352383
    Abstract: A brain-penetrating composition of amyloid-ß binding peptide is disclosed. This may be useful in the treatment of Alzheimer's disease, for example as a bifunctional molecule, comprising a blood-brain barrier crossing antibody and an amyloid-ß targeting peptide linked via an Fc fragment that is able to transmigrate across the blood-brain barrier into the brain, and compositions comprising same. Methods of using this composition for treating Alzheimer's disease are disclosed.
    Type: Application
    Filed: January 30, 2018
    Publication date: November 21, 2019
    Applicant: National Research Council of Canada
    Inventors: Balu Chakravarthy, Danica Stanmirovic, Yves Durocher
  • A?-binding protein and its peptide derivatives and uses thereof
    Patent number: 8323925
    Abstract: A protein kinase C inhibitor that binds ?-amyloid and its peptide derivatives with the same function are disclosed. These may be useful in the treatment of Alzheimer's disease, for example as pseudo vaccines comprising antibodies, or as part of fusion proteins which are able to pass through cell membranes or through the blood-brain barrier. Methods of using the PKC inhibitor and its peptide derivatives for treating Alzheimer's disease are also disclosed.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: December 4, 2012
    Inventor: Balu Chakravarthy
  • Novel Alphabeta-Binding protein and its peptide derivatives and uses thereof
    Publication number: 20110300141
    Abstract: A protein kinase C inhibitor that binds B-amyloid and its peptide derivatives with the same function are disclosed. These may be useful in the treatment of Alzheimer's disease, for example as pseudo vaccines comprising antibodies, or as part of fusion proteins which are able to pass through cell membranes or through the blood-brain barrier. Methods of using the PKC inhibitor and its peptide derivatives for treating Alzheimer's disease are also disclosed.
    Type: Application
    Filed: June 16, 2006
    Publication date: December 8, 2011
    Inventor: Balu Chakravarthy