Patents by Inventor Bang-Chi Chen

Bang-Chi Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing azacycloalkanoylaminothiazoles
    Publication number: 20010006976
    Abstract: The present invention relates to new, efficient processes for the preparation of 5-(2-oxazolylalkylthio)-2-azacycloalkanoylaminothiazole compounds of formula I 1
    Type: Application
    Filed: December 22, 2000
    Publication date: July 5, 2001
    Inventors: Bang-Chi Chen, Kyoung S. Kim, S. David Kimball, Raj N. Misra, Mark E. Salvati, Joseph E. Sundeen, Hai-Yun Xiao, Rulin Zhao
  • Process for preparing arylacetylaminothiazoles
    Publication number: 20010004639
    Abstract: The present invention relates to new, efficient processes for the preparation of 5-(2-oxazolylalkylthio)-2-arylacetylaminothiazole compounds of formula I 1
    Type: Application
    Filed: December 22, 2000
    Publication date: June 21, 2001
    Inventors: Bang-Chi Chen, Kyoung S. Kim, S. David Kimball, Raj N. Misra, Joseph E. Sundeen, Rulin Zhao
  • Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines
    Patent number: 6160134
    Abstract: A process is provided for preparing chiral cyclopropane carboxylic acids, preferably of the structure ##STR1## which are intermediates used in preparing acyl guanidine sodium/proton exchange (NHE) inhibitors.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: December 12, 2000
    Assignee: Bristol-Myers Squibb co.
    Inventors: Bang-Chi Chen, Joseph E. Sundeen, Jeffrey T. North, Annie J. Pullockaran, Saleem Ahmad, Shung C. Wu, Karnail S. Atwal, Sundeep Dugar
  • Reductive alkylation of secondary amines with hydrosilane
    Patent number: 6100395
    Abstract: A novel process for the production of tertiary amines by reductive alkylation of second amine using hydrosilane and a Lewis acid is disclosed. The novel process has applications in the preparation of imidazole-containing benzodiazepines, inhibitors of farnesyl protein transferase.
    Type: Grant
    Filed: January 10, 2000
    Date of Patent: August 8, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Bang-Chi Chen, Joseph E. Sundeen, Peng Guo
  • Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methyluridine
    Patent number: 5672698
    Abstract: An economical process, amenable to large-scale production, is disclosed for the preparation of 2',3'-didehydro-3'-deoxythymidine (d4T) from 5-methyluridine. The process employs a novel, 5'-,acyl-2'.alpha.-halo-3'.alpha.-alkanesulfonylthymidine intermediate as well as a highly efficient and practical deprotection, isolation and purification procedure for the d4T product.
    Type: Grant
    Filed: September 23, 1994
    Date of Patent: September 30, 1997
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Bang-Chi Chen, Derron Ray Stark, Stephen Richard Baker, Sandra L. Quinlan
  • Preparation of d4T from 5-methyluridine
    Patent number: 5608049
    Abstract: The present invention concerns an improved process of making d4T from 5-MU. Another aspect of the invention relates to useful intermediates produced during the process.
    Type: Grant
    Filed: March 10, 1995
    Date of Patent: March 4, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Richard H. Spector, Bang-Chi Chen, Sandra L. Quinlan
  • Process for preparing AZT
    Patent number: 5466787
    Abstract: A process for preparing AZT and comprising the steps of:a) reacting a 2'-halo-5'-protected pyrimidinyl 2'-deoxyribonucleoside having a 3'-sulfonyl group with tributyl tin hydride and catalytic amount of azobisisobutyronitrile in an ether, ester, or ketone solvent to yield a dehalogenated pyrimidinyl 2'-deoxyribonucleoside; followed byb) reacting said dehalogentated pyrimidinyl 2'-deoxynucleoside formed in step (a) with a base, a lithium salt, and an azide salt to yield a 5'-protected pyrimidinyl 3'-dideoxy-3'-azido-ribonucleoside; andc) deprotecting the nucleoside derivative of step (b) to yield 3'-dideoxy-3'-azidothymidine.
    Type: Grant
    Filed: November 15, 1993
    Date of Patent: November 14, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Bang-Chi Chen, Sandra L. Quinlan